The Healing Properties of Merthiolate*

Powell, H. M.; Jamieson, W. A.; Kempf, G. F.

doi:10.1093/oxfordjournals.aje.a117815

Cited by 2 publications

(4 citation statements)

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“…All were modest studies with Hammett and Reimann displaying accelerated healing in 20 of 25 wounds. Similar findings were reported with rats and rabbits with Powell et al . In neither case was a quantitative measure of healing provided.…”

Section: Early Product Testing and Applicationssupporting

confidence: 87%

“…The authors recommended use of the cysteine treatment for resistant cases. Similar clinical success was reported by Powell et al . with merthiolate in the treatment of a broad array of stubborn ulcers and abscesses, although the number of patients was not given.…”

Section: Early Product Testing and Applicationssupporting

confidence: 71%

“…Powell et al . also compared the response in nine normal subjects given 39 scraping wounds (about four to five wounds/person) (1/8 × 1/2 inch area and to a depth that would elicit capillary bleeding).…”

Section: Early Product Testing and Applicationsmentioning

confidence: 99%

“…Several papers assessed the capacity of various SH compounds to enhance wound healing in rats and rabbits. These studies used thiocresol, merthiolate, and thioglycerol . All were modest studies with Hammett and Reimann displaying accelerated healing in 20 of 25 wounds.…”

Section: Early Product Testing and Applicationsmentioning

confidence: 99%

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Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Calabrese

2013

Wound Repair Regeneration

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This paper provides a detailed historical assessment of the origin and developmental progress of the concept of wound healing and its attempted acceleration from its start in the beginning of the 20th century to approximately 1960. Emphasis is placed on the development of cell culture in the assessment of wound healing and in attempts to validate experimental findings via clinical research. Of particular interest were the observations that wound healing could be accelerated in the 30-50% range with the dose response displaying biphasic characteristics consistent with the hormesis dose-response model. Such findings set the stage for the hormetic dose-response revolution that is occurring within the biological and biomedical sciences, including wound healing, whereby considerable research now supports the capacity for endogenous and exogenous agents to accelerate the process of wound healing and its functional performance.

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Section: Early Product Testing and Applicationssupporting

confidence: 87%

Section: Early Product Testing and Applicationssupporting

confidence: 71%

Section: Early Product Testing and Applicationsmentioning

confidence: 99%

Section: Early Product Testing and Applicationsmentioning

confidence: 99%

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