The Health Effects Institute's Biomarker Research in China

Richmond, Martha

doi:10.1080/00984100050166479

Journal of Toxicology and Environmental Health, Part A

2000

DOI: 10.1080/00984100050166479

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The Health Effects Institute's Biomarker Research in China

Martha Richmond¹

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Cited by 5 publications

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“…Different biomarkers have been proposed for assessing environmental benzene exposure (Richmond, 2000). In several studies, urinary t,t-MA has been used (Yu & Weisel, 1996;Ong et al, 1996;Dor et al, 1999).…”

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confidence: 99%

FAILURE OF URINARYtrans,trans-MUCONIC ACID AS A BIOMARKER FOR INDOOR ENVIRONMENTAL BENZENE EXPOSURE AT PPB LEVELS

Sanguinetti¹,

Accorsi²,

Barbieri³

et al. 2001

Journal of Toxicology and Environmental Health, Part A

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Benzene is a widespread pollutant whose main source in the environment is automotive emission. There is increasing interest in the exposure of the population to this pollutant as benzene is present also in the indoor environment due to cigarette smoke, drinking water, and food. The aim of this study was to evaluate, in an adult nonsmoking population not occupationally exposed to benzene, whether it is possible to detect differences in the urinary concentration of trans,trans-muconic acid (t,t-MA) between low and high environmental exposure to benzene. A study sample of 31 employees working in pharmacies in a large town in Italy with low environmental exposure to benzene (4.8 microg/m3) was compared to a high (8.1 microg/m3) benzene exposure group. Analysis of urinary t,t-MA was carried out by high-performance liquid chromatography (HPLC; photodiode array detector); analysis of environmental benzene samples was by gas chromatography/mass spectroscopy (GC-MS). The statistical analysis revealed no significant differences in urinary levels of t,t-MA of subjects with high (mean concentration: 157.9 microg/g creatinine) versus low exposure (mean concentration: 114.2 microg/g creatinine). Data show that it is difficult to correlate urinary t,t-MA with benzene exposure at parts per billion levels.

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mentioning

confidence: 99%

FAILURE OF URINARYtrans,trans-MUCONIC ACID AS A BIOMARKER FOR INDOOR ENVIRONMENTAL BENZENE EXPOSURE AT PPB LEVELS

Sanguinetti¹,

Accorsi²,

Barbieri³

et al. 2001

Journal of Toxicology and Environmental Health, Part A

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Risk management among benzene-exposed oil refinery workers

Tompa¹,

Jakab²,

Major³

2005

International Journal of Hygiene and Environmental Health

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An Analysis of the Risk of B-Lymphocyte Malignancies in Industrial Cohorts

Bukowski

Huebner²,

Schnatter³

et al. 2003

Journal of Toxicology and Environmental Health, Part A

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Among numerous studies of occupational groups with varied chemical exposures (e.g., farmers, petroleum workers, and rubber workers), some have reported excess risk for non-Hodgkin's lymphoma (NHL), multiple myeloma, and other cancers of the B-lymphocyte cell line. While not conclusive, these studies raise questions about the effects of chemical exposures on the lymphocytic versus myeloid cell lines. Almost 70 occupational cohort studies were identified that addressed B-cell cancer risks in 9 major industrial categories, in order to look for common patterns across industries. This effort was substantially limited by the inconsistent nature of lymphohematopoietic (LH) classification schemes across studies and over time, and the relative paucity of B-cell-specific results in studies for any given industry. Taking these limitations into consideration, a descriptive, graphical analysis suggested a pattern of B-cell cancer elevations in the rubber and "general chemical" industries, but no consistent patterns in petroleum production/distribution or petrochemical production. The limited data sources, which lack detail about differences in hazard and exposure for different types of products/chemicals, did not allow a comprehensive look at possible common exposures associated with B-cell cancer elevations across industries. This study suggests that evaluation of possible associations between specific chemical exposures and B-cell malignancies would require additional studies with clear and common definitions of B-cell outcomes. The article concludes by giving an example of a possible common framework for categorizing NHL, the diseases for which most classification issues arise.

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The Health Effects Institute's Biomarker Research in China

Cited by 5 publications

References 10 publications

FAILURE OF URINARYtrans,trans-MUCONIC ACID AS A BIOMARKER FOR INDOOR ENVIRONMENTAL BENZENE EXPOSURE AT PPB LEVELS

FAILURE OF URINARYtrans,trans-MUCONIC ACID AS A BIOMARKER FOR INDOOR ENVIRONMENTAL BENZENE EXPOSURE AT PPB LEVELS

Risk management among benzene-exposed oil refinery workers

An Analysis of the Risk of B-Lymphocyte Malignancies in Industrial Cohorts

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