The Healthy Mind, Healthy Mobility Trial

Gill, Dawn P.; Gregory, Michael; Zou, Guangyong; Liu-Ambrose, Teresa; Shigematsu, Ryosuke; Hachinski, Vladimir; Fitzgerald, Clara; Petrella, Robert J.

doi:10.1249/mss.0000000000000758

Cited by 39 publications

(38 citation statements)

References 47 publications

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“…In sum, we speculate that the lack of SSE superior effects to drive between-group differences in DT gait parameters may be due to two main reasons: 1) the short duration and different frequency in which the mind-motor component was administered compared to previous studies (Gill et al, 2016;Teixeira et al, 2013), along with the low-intensity aspect of the SSE component; and 2) SSE could target specific cognitive functions/brain networks different from those required under DT gait conditions and, therefore, a significant treatment effect could not be expected under these circumstances. Another relevant factor to be taken into account when interpreting our findings is participants' baseline characteristics.…”

Section: Discussionmentioning

confidence: 82%

“…Square-stepping exercise (SSE) is a group-based, low-intensity exercise program that has been associated with improvements in lower extremity functional fitness and reduced fall risk in older adults at high risk of falling (Shigematsu et al, 2008a). The SSE intervention is best characterized as a visuospatial working memory task with a stepping response on a gridded floor mat, and thus, may be considered as a novel form of mind-motor training (Gill et al, 2016).…”

Section: Boa Sorte Silvamentioning

confidence: 99%

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Multiple-modality exercise and mind-motor training to improve mobility in older adults: A randomized controlled trial

Silva

Gill

Gregory

et al. 2018

Experimental Gerontology

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Section: Discussionmentioning

confidence: 82%

Section: Boa Sorte Silvamentioning

confidence: 99%

Multiple-modality exercise and mind-motor training to improve mobility in older adults: A randomized controlled trial

Silva

Gill

Gregory

et al. 2018

Experimental Gerontology

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“…There are numerous studies between physical activity and current cognition performance affected by present and earlier lifestyle activities [17–20, 42]. A meta-analysis examining the relationship between physical activity and Alzheimer's disease reported multiple neurotrophic factors resulting from physical activity had a protective cognitive effect [43].…”

Section: Discussionmentioning

confidence: 99%

Short-Term Lifestyle Strategies for Sustaining Cognitive Status

Howard

Morris

Steel

et al. 2016

BioMed Research International

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Cognitive decline impacts older adults, particularly their independence. The goal of this project was to increase understanding of how short-term, everyday lifestyle options, including physical activity, help an older adult sustain cognitive independence. Using a secondary analysis of lifestyle choices, we drew on a dataset of 4,620 community-dwelling elders in the US, assessed at baseline and one year later using 2 valid and reliable tools, the interRAI Community Health Assessment and the interRAI Wellness tool. Decline or no decline on the Cognitive Performance Scale was the dependent variable. We examined sustaining one's status on this measure over a one-year period in relation to key dimensions of wellness through intellectual, physical, emotional, social, and spiritual variables. Engaging in physical activity, formal exercise, and specific recreational activities had a favorable effect on short-term cognitive decline. Involvement with computers, crossword puzzles, handicrafts, and formal education courses also were protective factors. The physical and intellectual domains of wellness are prominent aspects in protection from cognitive decline. Inherent in these two domains are mutable factors suitable for targeted efforts to promote older adult health and well-being.

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“…The color-naming Stroop test will be used to assess the abilities of inhibition, set-shifting, and selective attention [19]. The participants will be tested under congruent and incongruent conditions.…”

Section: Methodsmentioning

confidence: 99%

“…Both studies found that the combined therapy induced significantly greater improvements on various cognitive functions in adults with MCI compared with the control groups that received health education programs [16, 17]. Another trial of dual-task training found that group-based training for 26 weeks improved global cognitive function in older adults with MCI compared with an exercise-only group, which highlighted the finding that group-based dual-task training enhanced global cognitive function [19]. …”

Section: Introductionmentioning

confidence: 99%

Evolving methods to combine cognitive and physical training for individuals with mild cognitive impairment: study protocol for a randomized controlled study

Lee

Teng

et al. 2016

Trials

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BackgroundNonpharmacologic interventions, such as cognitive training or physical exercise, are effective in improving cognitive functions for older adults with mild cognitive impairment (MCI). Some researchers have proposed that combining physical exercise with cognitive training may augment the benefits of cognition. However, strong evidence is lacking regarding whether a combined therapy is superior to a single type of training for older adults with MCI. Moreover, which combination approach – combining physical exercise with cognitive training sequentially or simultaneously – is more advantageous for cognitive improvement is not yet clear. This proposed study is designed to clarify these questions.Methods/designThis study is a single-blinded, multicenter, randomized controlled trial. Eighty individuals with MCI will be recruited and randomly assigned to cognitive training (COG), physical exercise training (PE), sequential training (SEQ), and dual-task training (DUAL) groups. The intervention programs will be 90 min/day, 2–3 days/week, for a total of 36 training sessions. The participants in the SEQ group will first perform 45 min of physical exercise followed by 45 min of cognitive training, whereas those in the DUAL group will perform physical exercise and cognitive training simultaneously. Participants will be assessed at baseline, after the intervention, and at 6-month follow-up. The primary cognitive outcome tests will include the Montreal Cognitive Assessment and the color-naming Stroop test. Other outcomes will include assessments that evaluate the cognitive, physical, and daily functions of older adults with MCI.DiscussionThe results of this proposed study will provide important information regarding the feasibility and intervention effects of combining physical exercise and cognitive training for older individuals with MCI.Trial registrationClinicalTrials.gov Identifier: NCT02512627, registered on 20 July 2015.

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The Healthy Mind, Healthy Mobility Trial

Abstract: A 26-wk group-based exercise program combined with dual-task training improved GCF in community-dwelling older adults without dementia.

Cited by 39 publications

References 47 publications

Multiple-modality exercise and mind-motor training to improve mobility in older adults: A randomized controlled trial

Multiple-modality exercise and mind-motor training to improve mobility in older adults: A randomized controlled trial

Short-Term Lifestyle Strategies for Sustaining Cognitive Status

Evolving methods to combine cognitive and physical training for individuals with mild cognitive impairment: study protocol for a randomized controlled study

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