The heart of the matter: Cardiac manifestations of endocrine disease

Binu, Aditya John; Cherian, Kripa Elizabeth; Kapoor, Nitin; Chacko, Sujith Thomas; George, Oommen K; Paul, Thomas

doi:10.4103/ijem.ijem_212_17

Cited by 7 publications

(3 citation statements)

References 69 publications

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“…During the clinical examination, the most common finding from the cardiovascular system is tachycardia, with 90% of patients having a resting heart rate above 90 bpm. [8][9][10] In this case, the patient presented to the Emergency Department of ZAH with complaints of shortness of breath. The patient also complains of chest palpitations, is often anxious and has trouble sleeping.…”

Section: Discussionmentioning

confidence: 97%

Thyroid Heart Disease in Young Male, a Case Report

Sihite¹,

Hambali

Kamil

et al. 2023

JSocMed

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The thyroid gland produces thyroid hormones that affect all tissue's metabolic processes, including the heart. Disorders of thyroid hormones, both increasing and decreasing thyroid hormones, can cause similar symptoms to primary heart disease. Thyroid heart disease (THD) is a heart disease that occurs due to increasing (hyperthyroid) or decreasing (hypothyroid) thyroid hormones in the circulation. Hyperthyroidism can cause several types of heart disease, including mitral regurgitation, tricuspid regurgitation, cardiomyopathy, heart failure, mitral valve prolapses, atrial fibrillation, or sinus tachycardia. Almost all cases of THD occur in middle-aged women. Here we presented a 32-year-old male patient diagnosed with THD caused by graves' disease. The patient was admitted to the emergency department due to shortness of breath. Medical and non-medical treatments were administered to the patients, and patients experienced improvement after several days of hospitalization. The progression of hyperthyroidism is characterized by remission and long-term exacerbations. Although some patients can remain euthyroid for a long time after therapy, many eventually get into hypothyroidism. Therefore, lifetime follow-up is an indication for all patients with hyperthyroidism.

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Section: Discussionmentioning

confidence: 97%

Thyroid Heart Disease in Young Male, a Case Report

Sihite¹,

Hambali

Kamil

et al. 2023

JSocMed

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“…Effects of the endocrine system on heart development [ 100 , 136 ] and function [ 25 , 238 ] are well known, and indications for a significant role of hormones in cardiovascular diseases consolidate. For example, it has been known for decades that women are at lower risk of developing ischemic heart disease, which is in part attributed to protective effects of estrogens [ 29 , 143 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic effects of hormones on structural and functional maturation of cardiomyocytes and implications for heart regeneration

Galow

Brenmoehl

Hoeflich

2023

Cell. Mol. Life Sci.

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The limited endogenous regenerative capacity of the human heart renders cardiovascular diseases a major health threat, thus motivating intense research on in vitro heart cell generation and cell replacement therapies. However, so far, in vitro-generated cardiomyocytes share a rather fetal phenotype, limiting their utility for drug testing and cell-based heart repair. Various strategies to foster cellular maturation provide some success, but fully matured cardiomyocytes are still to be achieved. Today, several hormones are recognized for their effects on cardiomyocyte proliferation, differentiation, and function. Here, we will discuss how the endocrine system impacts cardiomyocyte maturation. After detailing which features characterize a mature phenotype, we will contemplate hormones most promising to induce such a phenotype, the routes of their action, and experimental evidence for their significance in this process. Due to their pleiotropic effects, hormones might be not only valuable to improve in vitro heart cell generation but also beneficial for in vivo heart regeneration. Accordingly, we will also contemplate how the presented hormones might be exploited for hormone-based regenerative therapies. Graphical abstract

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“…Prior reviews have dealt with pathophysiology and cardiac manifestations of various endocrine disorders. 2 , 3 Here, we shall discuss endocrine disorders with potential of index presentation with HF. Except for thyroid disorders, pheochromocytoma/paraganglioma (PPGL) and primary hyperaldosteronism, other disorders dealt in this review have rare presentations.…”

Section: Introductionmentioning

confidence: 99%

Endocrine causes of heart failure: A clinical primer for cardiologists

Khatiwada

Boro

Farooqui³

et al. 2021

Indian Heart Journal

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Heart failure (HF) may be a presenting manifestation of a few endocrine disorders and should be considered in evaluation of heart failure causes. This clinically oriented review is an attempt to highlight the protean manifestations of heart failure in endocrine diseases which could present either as acute or chronic heart failure. Acute heart failure manifests as hypertensive crisis, Takotsubo syndrome, or as tachy/brady cardiomyopathies. Chronic heart failure could masquerade with features of hyperdynamic heart failure, or hypertrophic, restrictive or dilated cardiomyopathy. Rarely constrictive features or resistant heart failure could be the presenting feature. Isolated presentation as pulmonary hypertension and right heart failure are also documented. Good history-taking and physical examination with targeted investigations will help in the timely management for reversing the pathophysiology to a significant extent by appropriated management.

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The heart of the matter: Cardiac manifestations of endocrine disease

Cited by 7 publications

References 69 publications

Thyroid Heart Disease in Young Male, a Case Report

Thyroid Heart Disease in Young Male, a Case Report

Synergistic effects of hormones on structural and functional maturation of cardiomyocytes and implications for heart regeneration

Endocrine causes of heart failure: A clinical primer for cardiologists

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