The hepatoprotective activity against ethanol-induced cytotoxicity by aqueous extract of Antrodia cinnamomea

Ho, Yi-Chien; Lin, Ming-Tse; Duan, Kow‐Jen; Chen, Yen-Shang

doi:10.1016/j.jcice.2008.03.008

Cited by 15 publications

(13 citation statements)

References 28 publications

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“…The possible role of EPS in hepatoprotection has also been discussed. For example, the hepatoprotective activity of water extracts containing EPS from Antrodia cinnamomea on ethanol-induced cytotoxicity in AML12 hepatocytes was determined (Ho et al 2008 ).…”

Section: Production Of Eps By Ascomycota and Basidiomycota Fungal Strmentioning

confidence: 99%

Extracellular polysaccharides from Ascomycota and Basidiomycota: production conditions, biochemical characteristics, and biological properties

Osińska-Jaroszuk

Jarosz-Wilkołazka

Jaroszuk-Ściseł

et al. 2015

World J Microbiol Biotechnol

116

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Fungal polysaccharides (PSs) are the subject of research in many fields of science and industry. Many properties of PSs have already been confirmed and the list of postulated functions continues to grow. Fungal PSs are classified into different groups according to systematic affinity, structure (linear and branched), sugar composition (homo- and heteropolysaccharides), type of bonds between the monomers (β-(1 → 3), β-(1 → 6), and α-(1 → 3)) and their location in the cell (cell wall PSs, exoPSs, and endoPSs). Exopolysaccharides (EPSs) are most frequently studied fungal PSs but their definition, classification, and origin are still not clear and should be explained. Ascomycota and Basidiomycota fungi producing EPS have different ecological positions (saprotrophic and endophytic, pathogenic or symbiotic-mycorrhizae fungi); therefore, EPSs play different biological functions, for example in the protection against environmental stress factors and in interactions with other organisms. EPSs obtained from Ascomycota and Basidiomycota fungal cultures are known for their antioxidant, immunostimulating, antitumor, and antimicrobial properties. The major objective of the presented review article was to provide a detailed description of the state-of-the-art knowledge of the effectiveness of EPS production by filamentous and yeast Ascomycota and Basidiomycota fungi and techniques of derivation of EPSs, their biochemical characteristics, and biological properties allowing comprehensive analysis as well as indication of similarities and differences between these fungal groups. Understanding the role of EPSs in a variety of processes and their application in food or pharmaceutical industries requires improvement of the techniques of their derivation, purification, and characterization. The detailed analyses of data concerning the derivation and application of Ascomycota and Basidiomycota EPSs can facilitate development and trace the direction of application of these EPSs in different branches of industry, agriculture, and medicine.

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Section: Production Of Eps By Ascomycota and Basidiomycota Fungal Strmentioning

confidence: 99%

Extracellular polysaccharides from Ascomycota and Basidiomycota: production conditions, biochemical characteristics, and biological properties

Osińska-Jaroszuk

Jarosz-Wilkołazka

Jaroszuk-Ściseł

et al. 2015

World J Microbiol Biotechnol

116

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“…A. cinnamomea is expensive because of several characteristics, such as high medicinal value, scarcity in nature, and difficulty in artificial cultivation. The fruiting body and mycelium extracts of A. cinnamomea have been used as a medicine to improve the activity of organisms in studies involving cell lines and animal models in vivo and in vitro; A. cinnamomea extracts provide anti-oxidative [2], anticancer, anti-hepatitic [3], and anti-inflammatory properties [4]. Previous studies showed that the main active ingredients of A. cinnamomea are antroquinonol [5], succinic acid, maleic acid [6], benzenoids [7], triterpenoids [8], and polysaccharides [9].…”

Section: Introductionmentioning

confidence: 99%

Molecular cloning and expression analysis of mevalonate pyrophosphate decarboxylase inAntrodia cinnamomea

Lin

Shao

et al. 2016

MATEC Web of Conferences

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Abstract. Mevalonate pyrophosphate decarboxylase (MVD) plays important roles in triterpenoid biosynthesis via the mevalonate pathway. A novel MVD gene was isolated and identified in Antrodia cinnamomea (Ac-mvd). The fulllength cDNA contained an open reading frame with a length of 1,209 bp and encoded a 402-amino acid polypeptide with a molecular mass of 43.3 kDa and a theoretical pI of 8.23. As incubation time was prolonged for 28 days, the triterpenoid content in the mycelium gradually increased and reached 39.192 ± 2.025 mg/g; the triterpenoid content of the fruiting body grew in the hay of Cinnamomum kanehirae (ACFB-CK), was 49.391 ± 2.675 mg/g, which was significantly different from other samples (P < 0.05). qRT-PCR revealed that the highest expression levels of Ac-mvd in the mycelium of Antrodia cinnamomea were detected on the 7th day. The expression levels gradually decreased as culture time was extended from 14 days to 42 days.

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“…The hepatoprotective effects of the water extract from the mycelia of A. cinnamomea were also evaluated in vitro using ethanol-induced cytotoxicity on AML12 hepatocytes. The cytotoxicity and the apoptosis-associated phosphatidyl serine redistribution of plasma membrane to AML12 cells induced by 300 mM ethanol were effectively reduced by adding 500 mg/L of this extract (87) . It also prevents the elevation of total and direct bilirubin levels.…”

Section: Antrodia Cinnamomea (Family: Fomitopsidaceae): Antrodia Cinnmentioning

confidence: 99%

Include mushroom in daily diet—A strategy for better hepatic health

Chatterjee

Acharya

2015

Food Reviews International

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Liver, the most important metabolic organ of the body is also the major organ for the detoxification of the blood stream. If the accumulation of toxins is faster than their removal by liver, hepatic damage occurs. Although synthetic drugs are available in the market, long term use of such drugs has consequential side effects. Therefore, the growing need to find safe, costeffective drugs devoid of adverse effects is spawning extensive research. Mushrooms are rising as a major medicinal food and pharmaceuticals. This review summarizes the medicinal value of different edible mushrooms on free radical, xenobiotic and drug induced hepatotoxicity.

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The hepatoprotective activity against ethanol-induced cytotoxicity by aqueous extract of Antrodia cinnamomea

Cited by 15 publications

References 28 publications

Extracellular polysaccharides from Ascomycota and Basidiomycota: production conditions, biochemical characteristics, and biological properties

Extracellular polysaccharides from Ascomycota and Basidiomycota: production conditions, biochemical characteristics, and biological properties

Molecular cloning and expression analysis of mevalonate pyrophosphate decarboxylase inAntrodia cinnamomea

Include mushroom in daily diet—A strategy for better hepatic health

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