The herbal-derived honokiol and magnolol enhances immune response to infection with methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA)

Choi, Eun Jin; Kim, Hyung Ip; Kim, Ji Ae; Jun, Soo Youn; Kang, Sang Hoon; Park, Dong-Jun; Son, Seung Bae; Kim, Young-Hoon; Shin, Ok Sarah

doi:10.1007/s00253-015-6382-y

Cited by 25 publications

(22 citation statements)

References 46 publications

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“…Choi et al reported that honokiol and MG caused significant cellular immune-modulatory effect and decreased the production of ROS and inflammatory cytokines/ chemokines during S. aureus infection. Honokiol upregulated type I and III interferon mRNA expression in response to MSSA infection and inhibited the growth of MSSA at 2.5 μg ml −1 and MRSA at 5 μg ml −1 , whereas MG inhibited the growth of both bacterial cells at 5 μg ml −1 after 24 h of growing (Choi et al, 2015). MG and honokiol could inhibit S. mutans to prevent dental caries, with an MIC value of 10 μg ml −1 .…”

Section: Antibacterial Activitymentioning

confidence: 94%

Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update

Yong

Zeng

et al. 2021

Front. Pharmacol.

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Magnolol (MG) is one of the primary active components of Magnoliae officinalis cortex, which has been widely used in traditional Chinese and Japanese herbal medicine and possesses a wide range of pharmacological activities. In recent years, attention has been drawn to this component due to its potential as an anti-inflammatory and antitumor drug. To summarize the new biological and pharmacological data on MG, we screened the literature from January 2011 to October 2020. In this review, we provide an actualization of already known anti-inflammatory, cardiovascular protection, antiangiogenesis, antidiabetes, hypoglycemic, antioxidation, neuroprotection, gastrointestinal protection, and antibacterial activities of MG. Besides, results from studies on antitumor activity are presented. We also summarized the molecular mechanisms, toxicity, bioavailability, and formulations of MG. Therefore, we provide a valid cognition of MG.

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Section: Antibacterial Activitymentioning

confidence: 94%

Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update

Yong

Zeng

et al. 2021

Front. Pharmacol.

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“…In addition, magnolol significantly decreases ROS production and inflammatory cytokines expression in response to S. aureus in mouse macrophages. The internalization of S. aureus by human alveolar epithelial cells is also attenuated by magnolol [102]. Magnolol does not show any antagonistic effects on the 10 MRSA strains, when it is combined with the antibacterial agents synergistically.…”

Section: Clinical Prospectivementioning

confidence: 99%

Insights on the Multifunctional Activities of Magnolol

Zhang

Chen

Huang

et al. 2019

BioMed Research International

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Over years, various biological constituents are isolated from Traditional Chinese Medicine and confirmed to show multifunctional activities. Magnolol, a hydroxylated biphenyl natural compound isolated from Magnolia officinalis, has been extensively documented and shows a range of biological activities. Many signaling pathways include, but are not limited to, NF-κB/MAPK, Nrf2/HO-1, and PI3K/Akt pathways, which are implicated in the biological functions mediated by magnolol. Thus, magnolol is considered as a promising therapeutic agent for clinic research. However, the low water solubility, the low bioavailability, and the rapid metabolism of magnolol dramatically limit its clinical application. In this review, we will comprehensively discuss the last five-year progress of the biological activities of magnolol, including anti-inflammatory, antimicroorganism, antioxidative, anticancer, neuroprotective, cardiovascular protection, metabolism regulation, and ion-mediating activity.

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“…In a separate study, O. stamineus extract also modulated the cellular immune response in vitro (Alshawsh et al, 2012). Similarly, the natural polyphenols isolated from Magnolia plant species, honokiol and magnolol, promoted a cellular immune response and slowed down C. elegans killing by S. aureus (Choi et al, 2015). …”

Section: Identification Of Novel Anti-infectivesmentioning

confidence: 99%

Beyond Traditional Antimicrobials: A Caenorhabditis elegans Model for Discovery of Novel Anti-infectives

et al. 2016

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The spread of antibiotic resistance amongst bacterial pathogens has led to an urgent need for new antimicrobial compounds with novel modes of action that minimize the potential for drug resistance. To date, the development of new antimicrobial drugs is still lagging far behind the rising demand, partly owing to the absence of an effective screening platform. Over the last decade, the nematode Caenorhabditis elegans has been incorporated as a whole animal screening platform for antimicrobials. This development is taking advantage of the vast knowledge on worm physiology and how it interacts with bacterial and fungal pathogens. In addition to allowing for in vivo selection of compounds with promising anti-microbial properties, the whole animal C. elegans screening system has also permitted the discovery of novel compounds targeting infection processes that only manifest during the course of pathogen infection of the host. Another advantage of using C. elegans in the search for new antimicrobials is that the worm itself is a source of potential antimicrobial effectors which constitute part of its immune defense response to thwart infections. This has led to the evaluation of effector molecules, particularly antimicrobial proteins and peptides (APPs), as candidates for further development as therapeutic agents. In this review, we provide an overview on use of the C. elegans model for identification of novel anti-infectives. We highlight some highly potential lead compounds obtained from C. elegans-based screens, particularly those that target bacterial virulence or host defense to eradicate infections, a mechanism distinct from the action of conventional antibiotics. We also review the prospect of using C. elegans APPs as an antimicrobial strategy to treat infections.

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The herbal-derived honokiol and magnolol enhances immune response to infection with methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA)

Cited by 25 publications

References 46 publications

Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update

Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update

Insights on the Multifunctional Activities of Magnolol

Beyond Traditional Antimicrobials: A Caenorhabditis elegans Model for Discovery of Novel Anti-infectives

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