The herbal medicine Toki-shakuyaku-san improves the hypertension and intrauterine growth retardation in preeclampsia rats induced by Nω-nitro-L-arginine methyl ester

Takei, Hisato; Nakai, Yoichiro; Hattori, Naoko; Yamamoto, Masayuki; Kurauchi, Kouji; Sasaki, Hiroshi; Aburada, Masaki

doi:10.1078/0944-7113-00332

Cited by 33 publications

(22 citation statements)

References 16 publications

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“…(Rosaceae) leaf (Koçyildiz et al, 2006), Solanum anguivi Lam. (Solanaceae) (Bahgat et al, 2008), Fritillaria cirrhosa D. Don (Liliaceae) (Kang et al, 2004), bark of Mammea africana Sabine (Guttiferae) (Nguelefack-Mbuyo et al, 2008) and herbal formulation Toki-shakuyaku-san (Takei et al, 2004) in reducing l-NAME induced hypertension have been reported.…”

Section: Introductionmentioning

confidence: 99%

Antihypertensive and cardioprotective effects of theLagenaria sicerariafruit inN^G-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats

Mali

Bodhankar

2012

Pharmaceutical Biology

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Section: Introductionmentioning

confidence: 99%

Antihypertensive and cardioprotective effects of theLagenaria sicerariafruit inN^G-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats

Mali

Bodhankar

2012

Pharmaceutical Biology

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“…The placental weight of dams was not affected by L-NAME-infusion, but was significantly increased by TS treatment. The data of resorption and dead fetuses was not taken in this study because our previous study (10) had revealed that TS gave had no effect on fetal mortality and resorptions. In the previous study, the number of the resorptions and macerated fetuses are 1.5 ± 0.8 (control group: 0.9 ± 1.3) and 0.2 ± 0.4 (control group: 0), respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The yield of extract was about 18.2%. In this experiment, the TS was the same lot as that used in the previous report; its 3D HPLC profile and the ingredients present in TS have been described by Takei et al (10). Voucher specimens have been deposited in the Herbarium stock room of our laboratory.…”

Section: Drugsmentioning

confidence: 99%

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The Herbal Medicine Tokishakuyakusan Increases Fetal Blood Glucose Concentrations and Growth Hormone Levels and Improves Intrauterine Growth Retardation Induced by Nω-Nitro-L-arginine Methyl Ester

et al. 2007

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Abstract. N ω -Nitro-L-arginine methyl ester (L-NAME) induces a pre-eclampsia-like syndrome in pregnant rats. We have previously reported the anti-hypertensive effects of several Japanese traditional (Kampo) medicines in this model, and one of these, Tokishakuyakusan (TS), also improved intrauterine growth retardation (IUGR). In the present study, we characterized the effect of TS on IUGR. TS administration reversed the decrease in fetal body weight and fetal blood glucose concentration induced by the infusion of L-NAME. Growth hormone (GH) levels in the fetal blood, which were decreased by L-NAME infusion, were also significantly elevated by TS; however, levels of GH releasing hormone (GHRH) and insulin-like growth factor I (IGF-I) were unchanged and only slightly changed, respectively. Treatment with L-NAME with or without TS had no apparent effect on GH, GHRH, and IGF-I levels of dams. In an immunocytochemical study, the number of GH-positive cells in the fetal pituitary gland was significantly increased in TS-treated rats. These data suggest that enhanced proliferation of somatotrope cells of the pituitary gland and the resultant increase in GH secretion in the fetus may be involved in the improvement of IUGR by TS.

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“…In order to inhibits this dysfunction, a new approach by herbal treatment may promise. Recently, there were limited studies regarding the application of active compound from plants for preeclampsia [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Syzygium Cumini Reduces Vcam-1 and Icam-1 Expression in Endothelial Cells Induced by Plasma from Preeclamptic Patients

Wulandari¹,

Winarsih²,

Baktiyani³

2016

Med-Science

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The present study sought to investigate a role for Syzygium cumini on VCAM-1 and ICAM-1 expression in endothelial cells induced by plasma from preeclamptic patients. Endothelial cells were obtained from human umbilical vascular endothelial cells. At confluency, endothelial cells were divided into five groups, which included control (untreated), endothelial cells exposed to 2% plasma from preeclamptic patients (PP), endothelial cells exposed to PP in the presence of ethanolic extract of Syzygium cumini (PP + SC

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The herbal medicine Toki-shakuyaku-san improves the hypertension and intrauterine growth retardation in preeclampsia rats induced by Nω-nitro-L-arginine methyl ester

Cited by 33 publications

References 16 publications

Antihypertensive and cardioprotective effects of theLagenaria sicerariafruit inN^G-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats

Antihypertensive and cardioprotective effects of theLagenaria sicerariafruit inN^G-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats

The Herbal Medicine Tokishakuyakusan Increases Fetal Blood Glucose Concentrations and Growth Hormone Levels and Improves Intrauterine Growth Retardation Induced by Nω-Nitro-L-arginine Methyl Ester

Syzygium Cumini Reduces Vcam-1 and Icam-1 Expression in Endothelial Cells Induced by Plasma from Preeclamptic Patients

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The herbal medicine Toki-shakuyaku-san improves the hypertension and intrauterine growth retardation in preeclampsia rats induced by Nω-nitro-L-arginine methyl ester

Cited by 33 publications

References 16 publications

Antihypertensive and cardioprotective effects of theLagenaria sicerariafruit inNG-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats

Antihypertensive and cardioprotective effects of theLagenaria sicerariafruit inNG-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats

The Herbal Medicine Tokishakuyakusan Increases Fetal Blood Glucose Concentrations and Growth Hormone Levels and Improves Intrauterine Growth Retardation Induced by Nω-Nitro-L-arginine Methyl Ester

Syzygium Cumini Reduces Vcam-1 and Icam-1 Expression in Endothelial Cells Induced by Plasma from Preeclamptic Patients

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Product

Resources

About

Antihypertensive and cardioprotective effects of theLagenaria sicerariafruit inN^G-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats

Antihypertensive and cardioprotective effects of theLagenaria sicerariafruit inN^G-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats