The Heritability of Preterm Delivery

Ward, Kenneth; Argyle, VeeAnn; Meade, Mary; Nelson, Lesa

doi:10.1097/01.aog.0000189091.35982.85

Cited by 66 publications

(50 citation statements)

References 15 publications

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“…Наличие послед-ней группы и наталкивает на предположения о генети-ческих факторах недоношенности. Также красноречи-вы данные о наследуемости 17-36% преждевременных родов в различных популяциях [18][19][20][21]. Последнее круп-ное комплексное исследование в США на двухмиллион-ной выборке показало наследуемость преждевременных родов в пределах 25% [22].…”

Section: генетическая предрасположенностьunclassified

Neurogenetic Aspects of Perinatal Hypoxic-Ischemic Affections of the Central Nervous System

Каркашадзе¹,

Савостьянов²,

Макарова³

et al. 2016

Vopr. sovr. pediatr.

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Section: генетическая предрасположенностьunclassified

Neurogenetic Aspects of Perinatal Hypoxic-Ischemic Affections of the Central Nervous System

Каркашадзе¹,

Савостьянов²,

Макарова³

et al. 2016

Vopr. sovr. pediatr.

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“…Beside known risk factors, such as demographic characteristics, lifestyle and infection, genetic factors seem to play a crucial role in PTB [4,10,15,23,27]. One of the best predictors for preterm delivery is the women's history of a previous PTB [3].…”

Section: Introductionmentioning

confidence: 99%

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

et al. 2013

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Abstract.Oxytocin is crucially involved in the onset and maintenance of labor. We investigated the association between oxytocin receptor gene polymorphisms and preterm birth. The presence of four common oxytocin receptor gene polymorphisms (rs2254298, rs53576, rs2228485 and rs237911) was evaluated in one hundred women with preterm birth and one hundred healthy women using restriction fragment length polymorphism genotyping. No association was found between the presence of any individual oxytocin receptor gene polymorphism and preterm birth. In haplotype analysis, the haplotype combination of rs2254298 A allele, rs2228485 C allele and rs237911 G allele was found to be significantly associated with an increased risk of preterm birth (OR = 3.2 [CI 1.04-9.8], p = 0.043). In conclusion our findings suggest that a combination of three oxytocin receptor gene polymorphisms is associated with an increased risk for preterm birth. We propose further studies investigating the role of oxytocin receptor gene polymorphisms and preterm birth.

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“…Genetic predisposition for PTB [4][5][6] has been hypothesized based upon: 1) demonstration of familial aggregation; [7][8][9][10][11] 2) measures of heritability; [11][12][13][14][15] 3) identification of diseasesusceptibility genes; and 4) racial disparity in preterm birth rate [16][17][18][19] that may be related to frequency differences in risk predisposing alleles. [20][21][22][23][24] Familial aggregation, defined as the co-occurrence of a trait in members of a family that can not be readily accounted for by chance, has been demonstrated for PTB.…”

Section: Introductionmentioning

confidence: 99%

14: Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes

Romero¹,

Velez²,

Mazaki‐Tovi³

et al. 2009

American Journal of Obstetrics and Gynecology

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Objective-To determine whether maternal/fetal SNPs in candidate genes are associated with spontaneous preterm labor/delivery. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptStudy Design-A genetic association study was conducted in 223 mothers and 179 fetuses [preterm labor with intact membranes who delivered <37 weeks (PTB)], and 599 mothers and 628 fetuses (normal pregnancy): 190 candidate genes and 775 SNPs were studied. Single locus/ haplotype association analyses were performed; FDR was used to correct for multiple testing (q*=0.15)]. Results-1)The strongest single locus associations with PTB were IL6R (fetus: p=0.000148) and TIMP2 (mother: p=0.000197), remaining significant after correction for multiple comparisons; 2) Global haplotype analysis indicated an association between a fetal DNA variant in IGF2 and maternal COL4A3 (global p=0.004 and 0.007, respectively).Conclusion-A SNP involved in controlling fetal inflammation (IL6R) and DNA variants in maternal genes encoding for proteins involved in extracellular matrix biology approximately doubled the risk of PTB.

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The Heritability of Preterm Delivery

Abstract: This study confirms the familial nature of preterm delivery. On average, gravidae randomly selected from our population are 23rd degree relatives, while these preterm delivery probands are eighth-degree relatives. A genome-wide scan using these affected families is underway.

Cited by 66 publications

References 15 publications

Neurogenetic Aspects of Perinatal Hypoxic-Ischemic Affections of the Central Nervous System

Neurogenetic Aspects of Perinatal Hypoxic-Ischemic Affections of the Central Nervous System

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

14: Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes

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