Bilateral breast cancer (BBC) is rare and is associated with an unfavorable prognosis. Consequently it is crucial to improve diagnostic performance of breast cancer in the clinical setting. We report a case of BBC in a 66‐year‐old woman and describe the imaging findings, including mammography, hand‐held ultrasound, automated breast ultrasound, anatomical intelligence for breast ultrasound (AI‐breast), and magnetic resonance imaging. Only AI‐breast ultrasound successfully located the two tumors, while other imaging examinations failed to detect the tumor in the right breast.