The histaminolytic action of blood during pregnancy

Anrep, G. V.; Barsoum, G. S.; Ibrahim, Amal H.

doi:10.1113/jphysiol.1947.sp004218

Cited by 41 publications

(10 citation statements)

References 6 publications

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“…In accordance with the previous observation that histamine is probably not inactivated by blood corpuscles [Anrep et al, 1947], we found a slower histamine inactivation in whole blood of sheep than in plasma. The average histamine inactivation in sheep plasma (42-0 ,ug.…”

Section: Discussionsupporting

confidence: 80%

“…4). No such interfering activity was observed in the experiments of Anrep et al [1947] although the sheep serum must have constituted a higher percentage of the fluid volume in the bath than plasma did in the present experiments. In their experiments the incubation period was 30 min.…”

Section: Discussionmentioning

confidence: 45%

“…The stimulating substance(s) were inactivated after the release [Schachter, 1960]. It is thus conceivable that the dilution of the serum caused a rapid release of smooth muscle stimulating activity in the experiments of Anrep et al [1947] and that most of the activity had decayed when the incubation was terminated.…”

Section: Discussionmentioning

confidence: 99%

“…Human plasma heated to 80°C does not interfere with the determination of histamine on isolated guinea-pig ileum when present in concentrations of less than 5 per cent [Anrep et al, 1947;Wicksell, 1949] (2) Rat Uterus. -Virgin rats, weighing 130-160 g. were injected with diethylstilboestrol (10 ,g./100 g.) 16-20 hr.…”

mentioning

confidence: 99%

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Inactivation of Histamine and Occurrence of Smooth Muscle Stimulating Activity in Plasma of Sheep

Sjaastad¹

1967

Exp Physiol

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With incubation periods of 90 min., histamine inactivation in sheep plasma was nearly proportional to substrate concentration within the range of 2 to about 50 ,ug. histamine diphosphate/ml. plasma. Increasing the substrate concentration above 80 ,ug./ml. did not increase the histamine inactivation. At optimal substrate concentrations (80 pig./ml. plasma), a histamine inactivating capacity of 42-1±4-8 ,pg.histamine diphosphate/ml. plasma/hr. was found in seventeen sheep examined. About 80 per cent of the histamine inactivation was abolished by aminoguanidine, indicating that oxidative deamination is the major route of inactivation in sheep plasma in vitro.When plasma was incubated for more than 60 min. with an initial histamine concentration less than 20 ,ug./ml., smooth muscle stimulating activity interfering with the biological determination of histamine, was observed. Such activity developed rapidly when glass powder was added to plasma prepared with siliconized equipment and it is concluded that the interfering activity is due to substance(s) resembling bradykinin.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Inactivation of Histamine and Occurrence of Smooth Muscle Stimulating Activity in Plasma of Sheep

Sjaastad¹

1967

Exp Physiol

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“…Correction of the platelet count for dilution errors by use of the red cell count was calculated, but, as this did not result in any significant change in values, it has been omitted in the values reported. Blood histamine was measured on the guineapig ileum after isolation by the method of Code (1937) and also by direct assay of plasma, the technique of Anrep, Barsoum, and Ibrahim (1947) being used. It has been established that this technique can be satisfactorily applied to plasma (Scroggie and Jaques, 1948).…”

mentioning

confidence: 99%

A Study of the Toxicity of the Protamine, Salmine*

Jaques

1949

British Journal of Pharmacology and Chemotherapy

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The protamine, salmine, has become widely known in the combined form, protamine-insulin. It has been generally assumed that the protamines are non-toxic. Vartiainen and Marble (1941) found that the median lethal dose of salmine subcutaneously in mice and rabbits was 200-300 mg./kg. and concluded that it was non-toxic in ordinary doses-a view supported by its widespread clinical use with no allergic or other side-actions. Reiner, de Beer, and Green (1942) found an LD50 of 94 mg./kg. in mice with protamine (presumably salmine ?). Ahlstrom and von Euler (1946) have reported essentially similar results with rats and guinea-pigs, using salmine and also the related protamines, clupein and scombrin.A second possible clinical use of protamine is as an antidote for heparin, first suggested by Chargaff and Olsen (1937) and reported by Jorpes, Edman, and Thaning (1939). As the protamine for this purpose will probably be given intravenously, it raises the question of possible toxicity by this route. Thompson (1900) reported that the intravenous injection of the protamine, clupein, gave markedly toxic reactions in the narcotized dog, 15-18 mg./kg. killing the animals. The injection ofsmaller amounts of protamine caused a definite and relatively prompt fall in blood pressure, which returned to normal in 25-30 minutes. In addition to the fall in blood pressure, the respirations became markedly increased in rate and depth, and were followed by a period of apnoea. Thompson also noted a delayed clotting of the blood and a leucopenia.Jappelli (1933) confirmed Thompson's results with salmine using the unanaesthetized dog, as did Jaques, Charles, and Best (1938); 5 mg. salmine sulphate per kg. caused a pronounced fall in blood pressure and dyspnoea. However, they found that this protamine had relatively little effect on guineapigs, and this led to the present investigations. Shelley, Hodgkins, and Visscher (1942) reported that intravenous or intracardiac injection of 120 mg./kg.

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The histamine content of neoplastic pulmonary tissues

Bloomer

Lindskog

1948

Cancer

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The histaminolytic action of blood during pregnancy

Cited by 41 publications

References 6 publications

Inactivation of Histamine and Occurrence of Smooth Muscle Stimulating Activity in Plasma of Sheep

Inactivation of Histamine and Occurrence of Smooth Muscle Stimulating Activity in Plasma of Sheep

A Study of the Toxicity of the Protamine, Salmine*

The histamine content of neoplastic pulmonary tissues

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