The histogenesis of alveolar soft part sarcoma

Karnauchow, P. N.; Magner, D.

doi:10.1002/path.1700860121

Cited by 35 publications

(3 citation statements)

References 13 publications

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“…Review of the literature disclosed one previously reported case of alveolar soft part sarcoma of the mediastinum 21 . Although that tumour was reported as a mediastinal mass, the authors stated that the location of the tumour was in the hilum of the right lung, and described the neoplasm as composed of clusters of epithelioid and spindle cells.…”

Section: Discussionmentioning

confidence: 99%

Primary alveolar soft‐part sarcoma of the mediastinum: a clinicopathological and immunohistochemical study of two cases

1997

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Section: Discussionmentioning

confidence: 99%

Primary alveolar soft‐part sarcoma of the mediastinum: a clinicopathological and immunohistochemical study of two cases

1997

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“…The majority of the pathologists dealing with this tumor tried to present evidence for its myogenic origin [3,7,13,15,16,19,27,30,31,32,36]. Some other "lines of differentiations" (paraganglioma, granular cell myoblastoma, neural neoplasm, and angioreninoma) -although only transiently -have also been raised in the literature [9,23,32]. In spite of the number of publications on ASPS, none of them served sufficient evidence for the real origin, resulting in its classification as sarcoma of uncertain origin.…”

Section: Discussionmentioning

confidence: 97%

“…This fact raised the possibility of its muscle origin. However, some authors regarded the neoplasm as neurogenic [13,23,48]. The immunohistochemical analysis has also led to controversial results.…”

Section: Introductionmentioning

confidence: 95%

Cytogenetic abnormalities of alveolar soft-part sarcomas using interphase fluorescent in situ hybridization: trisomy for chromosome 7 and monosomy for chromosomes 8 and 18 seem to be characteristic of the tumor

et al. 2000

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Four alveolar soft-part sarcomas were investigated by means of standard immunohistochemistry and interphase cytogenetics to further characterize the immunophenotype and proliferative activity of this tumor. The main goal of this study was to explore the chromosomal changes of this rare soft-tissue sarcoma. One epithelial (KLI), three neurogenic [neuron specific enolase (NSE), PGP 9.5, and S100], and five myogenic (desmin, myoglobin, alpha-smooth mnuscle actin, alpha-sarcomeric actin, and MyoD1) markers were used for the immunophenotypical analysis. Proliferative activity was assessed using the Ki67 index. Twelve (peri)centromeric (1, 3, 4, 6, 7, 8, 10, 12, 15, 17, 18, and X) and one telomeric (17q25-qtel.) chromosomal probes were used for interphase cytogenetic analysis. Three of the cases showed cytoplasmic desmin and/or myoglobin, and one showed smooth muscle actin positivity. All of the four tumors had granular, cytoplasmic, possibly nonspecific MyoD1 and sarcomeric actin positivity. Two of the tumors were positive for vimentin, four gave focal and weak staining with neurogenic markers (four of four NSE, one of four S100, and four of four PGP 9.5), but none of them was positive with KLI. Alveolar soft-part sarcomas may show myogenic immunophenotype in a number of cases, which supports myogenic differentiation. Fluorescent in situ hybridization using alpha satellite chromosomal probes revealed significant alterations in all of the cases. Most frequent and repeated numerical changes, which seem to be characteristic of the neoplasm and may play an important part in its pathogenesis and/or progression, were trisomy 7, monosomy 8 and monosomy 18.

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Alveolar Soft Part Sarcoma of the Orbit

Altamirano-Dimas¹,

Albores‐Saavedra²

1966

Archives of Ophthalmology

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The histogenesis of alveolar soft part sarcoma

Cited by 35 publications

References 13 publications

Primary alveolar soft‐part sarcoma of the mediastinum: a clinicopathological and immunohistochemical study of two cases

Primary alveolar soft‐part sarcoma of the mediastinum: a clinicopathological and immunohistochemical study of two cases

Cytogenetic abnormalities of alveolar soft-part sarcomas using interphase fluorescent in situ hybridization: trisomy for chromosome 7 and monosomy for chromosomes 8 and 18 seem to be characteristic of the tumor

Alveolar Soft Part Sarcoma of the Orbit

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