The Histological and Biochemical Effects of Saffron on Schistosoma mansoni Infected Mice

Badr, Osama; Mohamed, Walead A.; Alkafafy, Mohamed; Khamiss, Omaima A.

doi:10.5455/ajvs.257434

Cited by 1 publication

(2 citation statements)

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“…Terpenoids are known to kill adult S. mansoniworms and cause complete separation of paired worms with tegumental disruption in worms (De Moraes, 2015). Oral administration of the alcoholic extract of saffron in adose of 100 mg/kg for 4 weeks to mice infected with S. mansoni caused significant reduction in egg count of Schistosoma when compared with infected control group (Badr et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Treatment with CSE alone or combined with PZQ resulted in a significant reduction in granuloma sizes compared to non-treated infected-mice. Badr et al (2017) reported that administration of the alcoholic extract of saffron in S. mansoni-infected mice caused remarkable reduction in the number and size of Schistosoma granuloma in the liver section. Saffron and its main ingredient (safranal) are antioxidants.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Crocus sativus aqueous extract (saffron) on Schistosoma mansoni worms in experimentally infected mice

Shaaban¹,

Ibrahim²,

Mohamed³

2019

Egypt. J. of Aquatic Biolo. and Fish.

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Saffron Granuloma Antioxidants Worm SEMThe present study is designed to evaluate the therapeutic effect of Crocus sativus(saffron) aqueous extract (CSE) alone or in combination with praziquantel on Schistosoma mansoni infected mice. Parasitological, immunological, pathological and immunohistochemical parameters and surface topography of worms were determined. Treatment of S. mansoni infected mice with saffron or PZQ revealed a significant reduction in worm burden, hepatic and intestinal ova count with a decline in granuloma diameter. There was an increase in total IgG and IL-10 blood levels after treatment with PZQ and/or CSE. Superoxide dismutase (SOD) and catalase levels were improved in infected mice treated with CSE in comparison with infected mice. Male worm surface ultrastructure examination showed a swelling, rupture of numerous tubercles with marked decrease in spines and severe peeling of tegumental dorsal surfaces after treatment with saffron. In conclusion, administration of aqueous extract of Crocus sativus is effective treatment for S. mansoni infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%