The History and Mystery of Carnoy Solution: An Assessment of the Need for Chloroform

Hellstein, John; Hopkins, Tamara; Morgan, Tracey

doi:10.1016/j.tripleo.2006.12.055

Cited by 20 publications

(15 citation statements)

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“…When the cystic lesion lies adjacent to vital structures, marsupialization or decompression is more wise approach in this situation [ 25 , 29 ]. On the other hand, if lesions are away from these vital structures, then chemical cauterization utilizing Carnoy's solution would be more acceptable given its ability to permeate and fix tissues up to a depth of 1.54 mm into the bone after 5 minutes of application [ 23 , 24 , 29 , 30 ]. Cryotherapy is another procedure which can give similar outcomes, but may produce complications such as wound dehiscence noted in most cases [ 24 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Odontogenic Keratocyst in Children: A Review

Kamil¹,

Tarakji

2016

TODENTJ

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Objective:Is to highlight the characteristics and management of odontogenic keratocyst in children onlyMaterial and Method:Computerized search in pubmed between (2005-2015) using specific words such as odontogenic keratocyst in children, odontogenic keratocyst association with Gorlin-Goltz syndrome with abstract written in English only.Result:During computerized literature search 77 articles in the years (2005-2015) were found. All these publications were miscellaneous studies including case series and case reports. Only 35 papers were selected which conform to our criteria. Most of the papers indicate that the histological type of keratocyst prevalent in children was parakeratinized variant, and most of the cases occurred in maxilla rather than mandible.Conclusion:We recommend that the surgeons who treat keratocysts in children take into consideration the late presentation in addition to the destructive nature and high recurrence rate. General practitioners face difficulty in early detection and referral of children with keratocysts or Gorlin syndrome. Treatment by multidiscplinary team is important if associated with Gorlin's syndrome Postoperative follow up is advised every 6 months.

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Section: Discussionmentioning

confidence: 99%

Odontogenic Keratocyst in Children: A Review

Kamil¹,

Tarakji

2016

TODENTJ

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“…The Carnoy's solutions used in this investigation were prepared by the same trained pharmaceutical, by using 6‐ml absolute ethanol, 3‐ml chloroform, 1‐ml acetic acid and 1‐g FeCl 3 .6H 2 O (ferric chloride hexahydrate) to obtain an approximately 10‐ml final solution . To obtain Carnoy's solution without chloroform, the 3 ml of chloroform was replaced by 3‐ml absolute ethanol …”

Section: Methodsmentioning

confidence: 99%

“…In 1992, American Food and Drug Administration (FDA) Compliance Policy Guide (chapter 4 subchapter 460) prohibited pharmaceutical compositions of therapeutic agents containing chloroform, as considered a carcinogenic compound . Indeed, this guidance promoted the replacement of chloroform and Carnoy's solution changed to the composition: 9‐ml absolute ethanol, 3‐ml acetic acid, and 1‐g ferric chloride . Nevertheless, both Carnoy's solutions (with and without chloroform) are currently used in clinical practice as adjunctive for several surgical interventions, and the principal parameters evaluated are the recurrence of lesions .…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and rheological characterization of different Carnoy's solutions applied in oral and maxillofacial surgery

Carvalho

Feitosa²,

Fonseca

et al. 2017

J Raman Spectroscopy

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Carnoy's solution has been widely undertaken as adjunctive therapy for benign odontogenic tumors. Although its outcomes were highly investigated, little information is available regarding its mechanism of action and the role of chloroform in composition. The aim of this study was to characterize Carnoy's solution (with and without chloroform) in order to survey its physicochemical and pharmacological properties. UV/Vis spectroscopy, Raman microspectroscopy, viscosity assessment, pH analysis, and ion (Fe3+) concentration were studied. All solutions were prepared by the same operator and assayed at each 7 days within a 4‐week period. All solutions depicted acidic pH whereas the viscosity was increased by the addition of chloroform. Starting in the seventh day after preparation, solutions with chloroform showed iron precipitation when nonfiltered. Carnoy's solution without chloroform was stable during the survey period as evidenced by Raman spectroscopy. In conclusion, Carnoy's solution possesses an acidic characteristic, it is stable when stored at room temperature, and precipitates iron salts when in the presence of chloroform in a nonfiltered solution. The chloroform increases the viscosity of the solution and makes its pH slightly more acidic when compared to the Carnoy's solution without chloroform. Raman spectroscopy favored the evaluation of components' stability in solutions by using the spectra analysis and the established correlations between the peaks in different periods.

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“…The problem of using Carnoy's solution in bone cavity is effect on the alveolar inferior nerve (if denuded or is free in the cavity after procedure). However, from the results of Frerich et al (1994), Loescher and Robinson (1998), Wolgen (1999) and Hellstein et al (2007) is not neurotoxic effect of Carnoy's solution permanent (if the application time is to 2 minutes). This confirms the results of our study: hypofunction of inferior alveolar nerve (manifested by hypoesthesia or anesthesia in mental nerve region) was not detected even in one patient.…”

Section: )mentioning

confidence: 96%

“…Carnoy's solution causes superficial necrosis of the bone to a depth of 1.5 mm. This mechanism eliminates remains of tumours cells and satellite microcysts (Hellstein et al, 2007;Madras and Lapointe, 2008). In both groups the recurrence rate was the same: 45.4%.…”

Section: Aggressive Treatment Meansmentioning

confidence: 99%

Keratocystic Odontogenic Tumour with Extraosseal Spread: Evaluation of the Effect Carnoy’s Solution

et al. 2015

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Keratocystic odontogenic tumour is relatively rare benign tumour. It is characterized by its fast aggressive growth and high risk of recurrence. Treatment is always surgical: conservative (enucleation, marsupialization) or aggressive (enucleation followed by application of Carnoy's solution, cryotherapy; peripheral ostectomy or en block resection of the jaw). Authors analysed retrospectively 22 patients who fulfilled inclusion criteria, i.e. had odontogenic keratocystic tumour of mandible, wherein antero-posterior dimension was at least 30 mm, and the tumour penetrated into the surrounding soft tissues. All patients underwent tumour enucleation, in 11 patients Carnoy's solution was given into the bone cavity after enucleation. The recurrence rate in the evaluation at least 36 months after surgery was both patient groups the same: 45.4%.

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The History and Mystery of Carnoy Solution: An Assessment of the Need for Chloroform

Cited by 20 publications

References 0 publications

Odontogenic Keratocyst in Children: A Review

Odontogenic Keratocyst in Children: A Review

Physicochemical and rheological characterization of different Carnoy's solutions applied in oral and maxillofacial surgery

Keratocystic Odontogenic Tumour with Extraosseal Spread: Evaluation of the Effect Carnoy’s Solution

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