The History of the Core–Shell Particles and Applications in Active Pharmaceutical Ingredients Via Liquid Chromatography

Synthesis and thermal stability of ZrO2@SiO2 core–shell submicron particles

“…Core-shell nano-and microparticles represent a novel class of functional materials with numerous prospective applications. For example, they are well-suited for applications in catalysis, [1][2][3][4][5][6][7] high performance liquid chromatography, [8][9][10] as well as biomedical diagnosis and therapy. 6,7,[11][12][13][14][15] Furthermore, they are highly promising candidates for the development of advanced optical materials, which are needed, e.g., for thermophotovoltaic (TPV) systems, 16,17 photonic displays, 18 and structural coloration.…”

Current developments in LC-MS for pharmaceutical analysis

“…Analysis time is typically decreased by a factor of 5−9 when a UHPLC column of 50 × 2.1 mm packed with sub-2 μm particles is used instead of a conventional HPLC column of 150 × 4.6 mm packed with 5 μm particles, while maintaining column efficiency 66 . Additionally, sub-3 μm SPP packed columns rival the efficiency of sub-2 μm FPP columns for small drugs, while only generating half the backpressure 67,68 . An evaluation of FPP and SPP columns for the analysis of drugs, including antipsychotics, antidepressants, anticonvulsants and andanxiolytics in biological samples by UHPLC-MS/MS was performed in 2017 by the Querioz group.…”

Functional Metal Organic Framework/SiO2 Nanocomposites: From Versatile Synthesis to Advanced Applications

“…Recently, superficially porous particles with a solid core and porous shell as the stationary phase for separation columns exhibited higher separation performance compared with only solid or porous materials [99,100,101,102]. Ahmed et al utilized silica microspheres modified with amino or carboxyl groups as the template core to synthesize copper-based HKUST-1 nanocrystals on them and finally obtained HKUST-1/SiO 2 microspheres with regular morphology [103].…”