The HLA-G 14 bp allele frequency in different populations: A global meta-analysis

HLA-G 14 bp Ins/Del (rs66554220) Variant Is Not Associated with Breast Cancer in Women from Western Mexico

“…It is important to mention that the frequency of rs6655420 allele/genotypes was in accordance with earlier reports from the West of Mexico [ 22 , 27 , 28 ]. Furthermore, according to Farias-Rodrigues et al, the insertion allele has a similar distribution around the world, indicating a possible action of balancing selection [ 29 ]. This fact is important because HLA-G’s pivotal function in the immune system and its putative beneficial role in maintaining genetic variability in different stages of immunological processes [ 29 ].…”

“…Furthermore, according to Farias-Rodrigues et al, the insertion allele has a similar distribution around the world, indicating a possible action of balancing selection [ 29 ]. This fact is important because HLA-G’s pivotal function in the immune system and its putative beneficial role in maintaining genetic variability in different stages of immunological processes [ 29 ]. In this way, it allows for a better understanding of the role of genetic variability in complex diseases such as BC.…”

Yoga, rheumatoid arthritis & human leukocyte antigen-G

“…Among these, nine variations are considered true polymorphisms because these account for more than 95 per cent of all haplotypes. A 14 bp insertion/deletion (rs 371194629) is an ancestral allele as it is also present in Africans 3 . The 14 bp insertion/deletion has been implicated in the HLA-G transcriptional levels and mRNA stability.…”