The homeogenetic induction of neural folds in rat embryos

, Y a r y l a n d EIGHT FIGURESLittle is known of the mechanisms of primary organization in mammalian embryos, largely because of technical difficulties in dealing with the early stages in. utero. A number of important problems can be approached (Nicholas, '47), however, by use of the techniques of explantation and transplantation, both separately and in combination. In earlier reports (Grobstein, '50b, '51) it was shown that individual mouse embryonic shields, separated from trophoblast and the remainder of the egg cylinder, can be cultivated for short periods embedded in a plasma clot in Carrel flasks. Upon implantation into the anterior chamber of an adult host eye such cultured shields survive, and show varying amounts of growth and differentiation depending on the stage of development at the time of explantation. The time of head process formation is of special importance. Subsequent to this time shields, whether implanted directly into the eye or implanted after a period in culture, grow rapidly and develop into teratoid masses including many cell types. Shields isolated prior to head process formation, however, are markedly affected by a period in culture. Although on direct implantaWith the technical assistance of Derrell

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The homeogenetic induction of neural folds in rat embryos

Cited by 12 publications

References 11 publications

Behavior of the mouse embryonic shield in plasma clot culture

Behavior of the mouse embryonic shield in plasma clot culture

Intra‐ocular growth and differentiation of the mouse embryonic shield implanted directly and following in vitro cultivation

Intra‐ocular growth and differentiation of clusters of mouse embryonic shields cultured with and without primitive endoderm and in the presence of possible inductors

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