The homogeneous and heterogeneous risk factors for the morbidity and prognosis of bone metastasis in patients with prostate cancer

Guo, Xu; Zhang, Chao; Guo, Qi; Xu, Yao; Feng, Guowei; Li, Lili; Han, Xiuxin; Lu, Feng Hwa; Ma, Yonggang; Wang, Xin; Wang, Guowen

doi:10.2147/cmar.s168579

Cited by 38 publications

(35 citation statements)

References 17 publications

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“…However, no information on the detailed surgical approaches adopted among osteosarcoma patients was recorded in the public SEER database. 19 to the limited sample size, we could not maintain enough statistical power to get a more stable result and, consequently, further studies are needed in order to confirm these results.…”

Section: Discussionmentioning

confidence: 92%

Lung metastases at the initial diagnosis of high-grade osteosarcoma: prevalence, risk factors and prognostic factors. A large population-based cohort study

Zhang¹,

Guo²,

Xu³

et al. 2019

Sao Paulo Med. J.

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INTRODUCTIONOsteosarcoma is the most prevalent malignant bone tumor in children and adolescents. An overall annual prevalence of 0.2-3 cases per 100,000 population has been reported. 1 Despite the rarity of osteosarcoma, it remains one of the deadliest cancers during the pubertal growth spurt. Lung metastases have been reported to be one of the challenging factors associated with a poor prognosis. 2 Approximately 20% of osteosarcoma patients present with metastatic disease at the time of the initial diagnosis. The most prevalent metastatic type is lung metastasis, which occurs in more than 80% of the cases. 3,4 Despite the development of novel treatments for osteosarcoma, 30-40% of these patients still relapse and the long-term post-relapse survival among these individuals has been reported to be less than 20%. 5,6 Undoubtedly, osteosarcoma patients can benefit from early diagnosis and treatment of metastases. Thus, a reasonable degree of lung metastasis screening for osteosarcoma patients at diagnosis is important. Male sex and the site involved (femur and tibia) were confirmed to be associate with greater occurrence of metastasis in a Mexican clinical trial. 7 The primary tumor size was reported to be a risk factor for lung metastasis among patients with osteosarcoma. 8,9 Currently, radiography is one of the most widely applied clinical screening strategies.However, radiography barely captures metastases until they physically form. Therefore, studies looking into the risk factors for lung metastasis occurrence among patients with osteosarcoma are warranted. ABSTRACT BACKGROUND: Osteosarcoma is the most prevalent malignant bone tumor in children and adolescents. Lung metastases are associated with poor prognosis. OBJECTIVE: The aim here was to explore the prevalence of and risk and prognostic factors for lung metastases in high-grade osteosarcoma patients. DESIGN AND SETTING: Retrospective cohort study based on the Surveillance, Epidemiology and End Results (SEER) database in the United States. METHODS: Data on 1,408 high-grade osteosarcoma patients registered in the SEER database between 2010 and 2015 were extracted. From these, all patients with high-grade osteosarcoma and initial lung metastasis were selected for analysis on risk and prognostic factors for lung metastases. Overall survival was estimated. RESULTS: There were 238 patients (16.90%) with lung metastases at diagnosis. Axial location, tumor size > 10 cm (odds ratio, OR 3.19; 95% confidence interval, CI: 1.58-6.45), higher N stage (OR 4.84; 95% CI: 1.94-12.13) and presence of bone metastases (OR 8.73; 95% CI: 4.37-17.48) or brain metastases (OR 25.63; 95% CI: 1.55-422.86) were significantly associated with lung metastases. Younger age and surgical treatment (hazard ratio, HR 0.46; 95% CI: 0.30-0.71) favored survival. Median survival was prolonged through primary tumor surgery. CONCLUSIONS:The factors revealed here may guide lung metastasis screening and prophylactic treatment for osteosarcoma patients. A primary tumor in an axial location, greater p...

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Section: Discussionmentioning

confidence: 92%

Lung metastases at the initial diagnosis of high-grade osteosarcoma: prevalence, risk factors and prognostic factors. A large population-based cohort study

Zhang¹,

Guo²,

Xu³

et al. 2019

Sao Paulo Med. J.

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“…Patients with cancer of the uterine cervix have been reported to have a relatively lower incidence of bone metastases when compared with cancer of the breast, lung, and prostate [ 17 – 19 ]. The present study showed that 2.42% of the study cohort of women with cervical cancer had bone metastases when initially diagnosed, which was a similar finding to that of the study conducted by Thanapprapasr et al (1.1%) [ 6 ], but was lower than that found in other studies [ 8 , 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Real-World Study of the Incidence, Risk Factors, and Prognostic Factors Associated with Bone Metastases in Women with Uterine Cervical Cancer Using Surveillance, Epidemiology, and End Results (SEER) Data Analysis

et al. 2018

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BackgroundThe aims of this study were to investigate the incidence and risk factors for the development of bone metastases and prognosis in women with cancer of the uterine cervix using database analysis.Material/MethodsThe National Cancer Institute (NCI) Surveillance, Epidemiology, and End Results (SEER) database was analyzed for the incidence and survival rates of women diagnosed with uterine cervical cancer in the United States between 2010–2015. Multivariate logistic regression analysis identified risk factors for bone metastases. Kaplan-Meier analysis estimated the overall survival. Proportional hazard regression analysis estimated prognostic factors associated with bone metastases.ResultsThere were 19,363 women with uterine cervical cancer, and 469 women were diagnosed with bone metastases on initial diagnosis (2.42%). Increased T-stage, N-stage, non-squamous and non-adenocarcinoma histology, high-grade tumors, and the presence of lung, liver, and brain metastases were all significantly associated with early bone metastases. There were 364 patients with cervical cancer and bone metastases on initial diagnosis who were followed-up for at least one year. Multivariate Cox regression analysis showed that unmarried status and lung, liver, and brain metastases were significantly associated with reduced overall survival. No other significant risk or prognostic associations were found.ConclusionsSEER data analysis showed that women with uterine cervical cancer had some standard risk factors associated with bone metastases, and with prognosis, but a heterogeneous group of risk factors was also present. The findings of this study may have clinical application in screening for bone metastases in women with cervical cancer.

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“…Prognostic factors in the cancer patients with distant metastases have been widely studied [14][15][16].…”

Section: Ivyspringmentioning

confidence: 99%

Prognosis for different patterns of distant metastases in patients with uterine cervical cancer: a population-based analysis

Zhang¹,

Guo²,

Zhou³

et al. 2020

J. Cancer

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Background: Uterine cervical cancer (UCC) is a common malignant tumor in women. We conducted this work to provide a though description on the patterns of distant metastases and to investigate the relevant factors for prognosis of UCC patients based on a large population. Patients and methods: UCC patients with FIGO stage IVB, being the study group, were identified from the Surveillance, Epidemiology, and End Result (SEER) database from 2010 to 2016. UCC patients with same inclusion criteria, being validation group, were identified from Tianjin First Central Hospital from 2004 to 2017. Patterns of distant metastases were described according to the number of metastatic sites. Survival of different patterns were calculated and prognostic factors were investigated by Cox hazard regression analysis. Results: Distant metastases were recorded in 1448 UCC patients among whom 295 patients (30.8%) developed metastases in two or more organs. Compared with the median OS of 8 (95%CI, 7.07-8.93) months in the patients with the single site, worse survival of 5 (95%CI, 4.29-5.71) months was noticed in the patients with multiple metastases. Age ≥ 65 years, black race, higher grade, higher T stage and more metastatic sites were proved to be the prognostic factors for all the patients in the advanced stage and the results were partly validated in the validation cohort. Moreover, black race and higher T-stage for the patients with the single metastatic sites and age ≥ 65, uninsured status, surgical treatment and metastatic pattern for the patients with two metastatic sites were prognostic factors. No independent factor was found in patients with three or more metastases. Conclusion: Around 70% of the patients suffered one site distant metastasis in UCC patients with IVB stage while 30% with multiple metastases and a significantly reduced survival. Different survivals and prognostic factors were noticed for different patterns of distant metastases.

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The homogeneous and heterogeneous risk factors for the morbidity and prognosis of bone metastasis in patients with prostate cancer

Cited by 38 publications

References 17 publications

Lung metastases at the initial diagnosis of high-grade osteosarcoma: prevalence, risk factors and prognostic factors. A large population-based cohort study

Lung metastases at the initial diagnosis of high-grade osteosarcoma: prevalence, risk factors and prognostic factors. A large population-based cohort study

Real-World Study of the Incidence, Risk Factors, and Prognostic Factors Associated with Bone Metastases in Women with Uterine Cervical Cancer Using Surveillance, Epidemiology, and End Results (SEER) Data Analysis

Prognosis for different patterns of distant metastases in patients with uterine cervical cancer: a population-based analysis

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