The HOTAIR, PRNCR1 and POLR2E polymorphisms are associated with cancer risk: a meta-analysis

Chu, Haiyan; Chen, Yaoyao; Yuan, Qinbo; Hua, Qiuhan; Zhang, Xu; Wang, Meilin; Tong, Na; Zhang, Wei; Chen, Jinfei; Zhang, Zhengdong

doi:10.18632/oncotarget.14920

Cited by 38 publications

(31 citation statements)

References 46 publications

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“…In a meta-analysis performed by Chu et al (34), the rs1016343 and rs16901946 variants of PRNCR1 were found to significantly increase the risk of cancer; however, their findings did not support a significant association of the rs13252298, rs7007694 and rs1456315 polymorphisms with cancer risk. Another meta-analysis conducted by Lv et al (35) also revealed that two polymorphisms (rs1016343 and rs16901946) of PRNCR1 were associated with increased cancer risk.…”

Section: Discussionmentioning

confidence: 90%

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Association between genetic polymorphisms of long non‑coding RNA PRNCR1 and prostate cancer risk in a sample of the Iranian population

et al. 2017

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Abstract. The aim of the present study was to determine whether there is an association between the long non-coding RNA (lncRNA) prostate cancer-associated non-coding RNA 1 (PRNCR1) polymorphisms and prostate cancer (PCa) risk in a sample of the Iranian population. This case-control study was performed on 178 patients with PCa and 180 subjects with benign prostatic hyperplasia (BPH). Genotyping assay was performed by polymerase chain reaction-restriction fragment length polymorphism. The findings indicated that the GG genotype of the rs13252298 A>G variant significantly increased the risk of PCa (odds ratio=3.49, 95% confidence interval: 1.79-6.81, P=0.0001) compared with AA+AG. As regards the rs1456315 G>A polymorphism, the AG genotype and G allele significantly increased the risk of PCa. As regards the rs7841060 T>G variant, the findings demonstrated that this TG genotype and the G allele significantly increased the risk of PCa. The rs7007694 T>C variant was not found to be associated with the risk of PCa. Haplotype analysis indicated that GTGA and GTGG significantly increased the risk of PCa compared with rs1456315A/rs7007694T/rs7841060T/rs13252298G (ATTG). The PRNCR1 variants were not found to be significantly associated with the clinicopathological characteristics of PCa patients. In conclusion, our findings support an association between PRNCR1 variants and the risk of PCa in a sample of the Iranian population.

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Section: Discussionmentioning

confidence: 90%

“…Association between genetic polymorphisms of long non-coding RNA PRNCR1 and prostate cancer risk in a sample of the Iranian population PRNCR1 variants that were identified as potential risk factors for cancer were selected (26,(28)(29)(30)34,35). Genetic risk factors for cancer may vary among diverse populations.…”

Section: Introductionmentioning

confidence: 99%

Association between genetic polymorphisms of long non‑coding RNA PRNCR1 and prostate cancer risk in a sample of the Iranian population

et al. 2017

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“…Another meta-analysis performed by Chu et al 24 revealed that HOTAIR rs920778 variant increases susceptibility to cancer. Their findings did not support an association between rs1899663 and rs4759314 variants and the risk of cancer.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms of HOTAIR gene are associated with the risk of breast cancer in a sample of southeast Iranian population

et al. 2017

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There is an increasing body of evidence which highlights the critical functions of long non-coding RNAs in the carcinogenicity mechanism of a variety of cancers. It has been reported that HOX transcript antisense intergenic RNA, a member of long non-coding RNA family, increases breast cancer risk. To date, no data regarding the association between HOX transcript antisense intergenic RNA polymorphisms and the risk of breast cancer development has been reported in Iran. Here, we examine the possible association between HOX transcript antisense intergenic RNA gene polymorphisms and breast cancer in a sample of southeast Iranian female population. The HOX transcript antisense intergenic RNA rs920778, rs12826786, rs4759314, and 1899663 gene polymorphisms were genotyped in 220 cases and 231 controls by polymerase chain reaction-restriction fragment length polymorphism. Our findings indicated that rs920778 polymorphism has significant positive association with breast cancer; rs12826786 and rs1899663 polymorphisms demonstrated significant negative association with breast cancer; and the rs4759314 variant was not associated with breast cancer risk. Haplotype analysis revealed that TGAC, CTAT, and TTAT haplotypes significantly decreased the risk of breast cancer compared with rs920778T/rs1899663G/rs4759314A/rs12826786T haplotype. In conclusion, we investigated only four variants of HOX transcript antisense intergenic RNA gene, and the findings suggest that HOX transcript antisense intergenic RNA rs920778, rs12826786, and rs1899663 polymorphisms may be associated with breast cancer risk in a sample of southeast Iranian population. Further replication studies with other polymorphisms of HOX transcript antisense intergenic RNA gene involving a greater sample size and different ethnicities are necessary to verify our findings.

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“…One of which is an antisense noncoding RNA in the INK4 locus ( ANRIL ), one is highly upregulated in liver cancer ( HULC ), one is a poly (ADP‐ribose) polymerase‐1 ( PARP1 ), and one is a RNA polymerase II polypeptise E gene ( POLR2E ). Chu et al concluded that POLR2E rs3787016 contributes to cancer risk by conducting a meta‐analysis; however, glioma was not included in the study. In addition, Wang et al demonstrated that HULC SNPs (rs1041279 and rs2038540) might enhance hepatocellular cancer risk, whereas they are not associated with overall survival.…”

Section: Introductionmentioning

confidence: 99%

Impact of four lncRNA polymorphisms (rs2151280, rs7763881, rs1136410, and rs3787016) on glioma risk and prognosis: A case‐control study

Deng

Zhou

et al. 2019

Molecular Carcinogenesis

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Long noncoding RNA (lncRNA) polymorphisms are reportedly in connection with tumor susceptibility and prognosis. Glioma is one of the most aggressive and common cancers of the central nervous system. This study aimed to investigate the relationship between four lncRNA variants and glioma susceptibility and prognosis in a Chinese Han population. Sequenom Mass‐ARRAY was used to genotype 605 patients with glioma and 1300 cancer‐free individuals. Odds ratios or hazard ratios and related 95% confidence intervals were calculated to estimate the correlations. Logistic and Cox regression models, log‐rank tests, and Kaplan‐Meier curves were used for the statistical analysis. Six inheritance models showed that ANRIL rs2151280 variant genotype (A>G) was related to the susceptibility of glioma, while the other three lncRNAs showed no association. Patients treated with temozolomide or nimustine had better progression‐free survival (PFS) and overall survival (OS) than those treated with platinum. Besides, patients aged older than 40 years showed a poorer OS. The Cox multivariate analysis revealed that the rs1136410 GG genotype (A>G) was beneficial for OS and PFS. The Kaplan‐Meier analyses indicated that rs1136410 A>G and the rs7763881 A>C were associated with longer OS. ANRIL rs2151280 variant genotype might increase susceptibility of glioma. In addition, PARP1 rs1136410 variant genotype could be beneficial for the overall survival of patients with glioma. More research data are needed to further validate our results.

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The HOTAIR, PRNCR1 and POLR2E polymorphisms are associated with cancer risk: a meta-analysis

Cited by 38 publications

References 46 publications

Association between genetic polymorphisms of long non‑coding RNA PRNCR1 and prostate cancer risk in a sample of the Iranian population

Association between genetic polymorphisms of long non‑coding RNA PRNCR1 and prostate cancer risk in a sample of the Iranian population

Genetic polymorphisms of HOTAIR gene are associated with the risk of breast cancer in a sample of southeast Iranian population

Impact of four lncRNA polymorphisms (rs2151280, rs7763881, rs1136410, and rs3787016) on glioma risk and prognosis: A case‐control study

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