The human cingulum: From the limbic tract to the connectionist paradigm

Maldonado, Igor Lima; Matos, Vitor Parente de; Cuesta, Taryn Ariadna Castro; Herbet, Guillaume; Destrieux, Christophe

doi:10.1016/j.neuropsychologia.2020.107487

Cited by 31 publications

(22 citation statements)

References 183 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The human cingulum bundle is considered to be a large-scale white matter system, carrying fibres associated with several different major white matter tracts, including those linking vmPFC, ACC and the presupplementary to the motor apparatus in supplementary motor and primary motor regions. 93 It has been linked to the initiation of self- rather than externally-generated movements 93 and lesions involving the cingulum can result in severe forms of apathy manifest as akinetic mutism. 34 , 35 The finding of cingulum involvement in our study is largely concordant with previous reports in both genetic 23 and sporadic 6 , 24 forms of SVD.…”

Section: Discussionmentioning

confidence: 99%

Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making

Saleh

Heron

Petitet

et al. 2021

Brain

View full text Add to dashboard Cite

Patients with small vessel cerebrovascular disease frequently suffer from apathy, a debilitating neuropsychiatric syndrome, the underlying mechanisms of which remain to be established. Here we investigated the hypothesis that apathy is associated with disrupted decision making in effort-based decision making, and that these alterations are associated with abnormalities in the white matter network connecting brain regions that underpin such decisions. Eighty-two patients with MRI evidence of small vessel disease were assessed using a behavioural paradigm as well as diffusion weighted MRI. The decision-making task involved accepting or rejecting monetary rewards in return for performing different levels of physical effort (hand grip force). Choice data and reaction times were integrated into a drift diffusion model that framed decisions to accept or reject offers as stochastic processes approaching a decision boundary with a particular drift rate. Tract-based spatial statistics were used to assess the relationship between white matter tract integrity and apathy, while accounting for depression. Overall, patients with apathy accepted significantly fewer offers on this decision-making task. Notably, while apathetic patients were less responsive to low rewards, they were also significantly averse to investing in high effort. Significant reductions in white matter integrity were observed to be specifically related to apathy, but not to depression. These included pathways connecting brain regions previously implicated in effort-based decision making in healthy people. The drift rate to decision parameter was significantly associated with both apathy and altered white matter tracts, suggesting that both brain and behavioural changes in apathy are associated with this single parameter. On the other hand, depression was associated with an increase in the decision boundary, consistent with an increase in the amount of evidence required prior to making a decision. These findings demonstrate altered effort-based decision making for reward in apathy, and also highlight dissociable mechanisms underlying apathy and depression in small vessel disease. They provide clear potential brain and behavioural targets for future therapeutic interventions, as well as modelling parameters that can be used to measure the effects of treatment at the behavioural level.

show abstract

Section: Discussionmentioning

confidence: 99%

Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making

Saleh

Heron

Petitet

et al. 2021

Brain

View full text Add to dashboard Cite

show abstract

“…The anterior cingulate cortex is related to cognitive control and decision-making, and the posterior cingulate cortex is involved in the adjustment of working memory, visual space, and spatial orientation. In particular, the anterior cingulate cortex plays a key role in error handling (Leech and Sharp, 2014;Bliss et al, 2016;Maldonado et al, 2020). Cingulate impairment in neurological and psychiatric disorders has been widely reported.…”

Section: Discussionmentioning

confidence: 99%

Abnormalities of Brain White Matter in Type 2 Diabetes Mellitus: A Meta-Analysis of Diffusion Tensor Imaging

Huang

Zhang

Tang

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

Aims: The study aimed to conduct a meta-analysis to determine the abnormalities of white matter in patients with type 2 diabetes mellitus (T2DM) by identifying the consistency of diffusion tensor imaging (DTI).Method: The literature for DTI comparing patients with T2DM with controls published before October 30, 2020, were reviewed in PubMed, Web of Science, Embase, CNKI, and Wan Fang databases. The meta-analysis was performed using the activation likelihood estimation (ALE) method, including 12 reports and 381 patients with T2DM.Results: The meta-analysis identified 10 white matter regions that showed a consistent reduction of fractional anisotropy (FA) in patients with T2DM, including genu of the corpus callosum, the body of corpus callosum, bilateral anterior corona radiata, bilateral superior corona radiata, bilateral cingulum, and bilateral superior fronto-occipital fasciculus.Conclusion: This study revealed the abnormal characteristics of white matter in T2DM, which would be helpful to understand the underlying neuropathological and physiological mechanisms of T2DM and provide evidence for clinical diagnosis and treatment.

show abstract

“…MMSE is a screening tool that provides a measure of global cognitive dysfunction and is developed to screen for Alzheimer's disease [7][8][9]; Although it has a proven prognostic value, it is neither a sensitive score nor can it be used to identify problems in given cognitive domains [10]. More specific scores for cognitive functioning can possibly predict survival in diffuse glioma patients more precisely and may reveal a causal relation of cognition, or its subcomponents, with survival [5,6,11].…”

Section: Introductionmentioning

confidence: 99%

Cognitive impairments are independently associated with shorter survival in diffuse glioma patients

et al. 2020

View full text Add to dashboard Cite

Background Diffuse gliomas (WHO grade II–IV) are progressive primary brain tumors with great variability in prognosis. Cognitive deficits are of important prognostic value for survival in diffuse gliomas. Until now, few studies focused on domain-specific neuropsychological assessment and rather used MMSE as a measure for cognitive functioning. Additionally, these studies did not take WHO 2016 diagnosis into account. We performed a retrospective cohort study with the aim to investigate the independent relationship between cognitive functioning and survival in treatment-naive patients undergoing awake surgery for a diffuse glioma. Methods In patients undergoing awake craniotomy between 2010 and 2017, we performed pre-operative neuropsychological assessments in five cognitive domains, with special attention for the domains executive functioning and memory. We evaluated the independent relation between these domains and survival, in a Cox proportional hazards model that included state-of-the-art integrated histomolecular (‘layered’ or WHO-2016) classification of the gliomas and other known prognostic factors. Results We included 197 patients. Cognitive impairments (Z-values ≦ − 2.0) were most frequent in the domains memory (18.3%) and executive functioning (25.9%). Impairments in executive functioning and memory were significantly correlated with survival, even after correcting for the possible confounders. Analyses with the domains language, psychomotor speed, and visuospatial functioning yielded no significant results. Extensive domain-specific neuropsychological assessment was more strongly correlated to survival than MMSE. Conclusion Cognitive functioning is independently related to survival in diffuse glioma patients. Possible mechanisms underlying this relationship include the notion of cognitive functioning as a marker for diffuse infiltration of the tumor and the option that cognitive functioning and survival are determined by overlapping genetic pathways and biomarkers.

show abstract

The human cingulum: From the limbic tract to the connectionist paradigm

Cited by 31 publications

References 183 publications

Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making

Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making

Abnormalities of Brain White Matter in Type 2 Diabetes Mellitus: A Meta-Analysis of Diffusion Tensor Imaging

Cognitive impairments are independently associated with shorter survival in diffuse glioma patients

Contact Info

Product

Resources

About