The human enteric coronaviruses

Abstract

SummaryA coronavirus was seen in the faeces from 15 (4-2%) of 355 adults with diarrhoea and from 5 (5-2%) of 96 adults without diarrhoea. Similar particles were seen in the faeces from 5 (2-2%) of 227 children aged 1-14 years with gastroenteritis, but in none of those from 230 infants under one year of age with gastroenteritis.

Detection of coronaviruses in children with acute gastroenteritis in Maddina, Saudi Arabia

“…This observation is consistent with previous studies which have generally documented that coronavirus diarrhoea is usually mild ( Table 1). [12][13][14][15][16][17][18][19][20][21][22][23][24][25] Secondly, the median age of children with coronavirus infection (42 months) was significantly greater than in children with rotavirus infection (10 months), 7 which raises the possibility of age-dependent differences in susceptibility to infection, or perhaps different modes of virus transmission. Thirdly, the seasonality of coronavirus infection differed from that of rotavirus; rotavirus infection was most common between November and January whereas the highest monthly detection rates of coronavirus were between January and March.…”

“…It is noteworthy that a study from a neighbouring country, Iran, reported that coronavirus ranked second (3%) to rotavirus as a cause of childhood viral gastro-enteritis. 25 However, while in some studies coronavirus has been associated with diarrhoea, 13,18,19,25 other studies have found coronavirus equally common in patients without diarrhoea. [15][16][17] Thus, the aetiological role of coronaviruses in human gastro-enteritis is not firmly established.…”

An Eight-Year Study of the Viral Agents of Acute Gastroenteritis in Humans: Ultrastructural Observations and Seasonal Distribution with A Major Emphasis on Coronavirus-like Particles

“…Coronaviruses and CVLPs are known to cause severe gastrointestinal illness in animals (Naqi et al, 1975;Horzinek and Osterhaus, 1979). Although many reports have appeared in the literature throughout the world identifying CVLPs as a possible etiologic agent of gastroenteritis in humans (Caul et al, 1975;Mathan et al, 1975;Baumeister et al, 1976;Maass et al, 1977;Moore et al, 1977;Rowland et al, 1978;Schnagl et al, 1978;Schnagl et al, 1979;Clarke et al, 1979;Maass and Baumeister, 1983;Gerna et al, 1985), CVLPs have also been identified in apparently healthy subjects (Mathan et al, 1975;Caul et al, 1975;Maass et al, 1977;Moore et al, 1977;Rowland et al, 1978;Schnagl et al, 1978;Schnagl et al, 1979;Clarke et al, 1979;Maass and Baumeister, 1983;Peigue et al, 1978;Weindling et al, 1980;Marshall et al, 1982;Puel et al, 1982;Sitbon, 1985). Although many reports have appeared in the literature throughout the world identifying CVLPs as a possible etiologic agent of gastroenteritis in humans (Caul et al, 1975;Mathan et al, 1975;Baumeister et al, 1976;Maass et al, 1977;Moore et al, 1977;Rowland et al, 1978;Schnagl et al, 1978;Schnagl et al, 1979;Clarke et a...…”

Broadly targeted multiprobe QPCR for detection of coronaviruses: Coronavirus is common among mallard ducks (Anas platyrhynchos)

“…However, there is also direct evidence for involvement in enteric (e.g. strain HECoV 4408) (Zhang et al, 1994;Zhu et al, 2006) and suggestive evidence for involvement in neurological disease (Clarke et al, 1979;Flewett et al, 1987;Foley and Leutenegger, 2001;Gerna et al, 1985Gerna et al, , 1984Han et al, 2006;Jacomy et al, 2006;Luby et al, 1999;Resta et al, 1985;Saif, 2004;Schnagl et al, 1990Schnagl et al, , 1986Sitbon, 1985;Vabret et al, 2006;Zhu et al, 2006). HCoV are frequent causes of the common cold; usually a self-limiting upper respiratory tract (URT) illness (Heikkinen and Jarvinen, 2003).…”