Ostensibly a book written with a view towards publicly promulgating an anti-racist agenda by synthesizing a vast body of mid-20th-century biological and genetic science, Fernando Ortiz’s El engaño de las razas (1946) remains one his least commented-upon works. Eclipsed in its scholarly reception (both nationally and internationally) by its immediate predecessor, El contrapunteo cubano del tabaco y el azúcar (1940) and its English translation (1946), El engaño de las razas also appears to have been shadowed by (or simply assimilated into) the spate of post-Second World War anthropological anti-racist pronouncements culminating in the 1951 UNESCO Declaration Against Racism. However, paying close attention to Ortiz’s analytical and rhetorical strategies reveals that El engaño is by no means a mere anti-racist tract in the guise of a (characteristically learned and vociferously poetic) Latin American ensayo. As I will argue, the text merits our attention today not only because it refracted and subjected a larger, international anthropological agenda of the time to a local perspective, but also because its analytical tropology – arguably – only entered anthropological theorizing about human biology, heredity, and sociality under the sign of relationality from the 1990s onward. I suggest that in outlining a metapragmatic ethics and politics of metaphor Ortiz also anticipated a de-stabilization of representationalist accounts of ‘race’ that goes well beyond social constructionism.