The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype

Nguyen, Mai; Lee, Maggie C.; Wang, Jing Liang; Tomlinson, James S.; Shao, Zhi Ming; Alpaugh, Mary L.; Barsky, Sanford H.

doi:10.1038/sj.onc.1203677

Cited by 78 publications

(64 citation statements)

References 27 publications

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“…These findings suggest that, in ILC, angiogenesis activation, although essential for tumour growth and progression, does not need VEGF overexpression but should be promoted through angiogenic factors others than VEGF, which might be HIF-1a-dependent. Otherwise, the presence of anti-angiogenic factors could also be hypothesised, as recently demonstrated in the myoepithelial cells surrounding lobular structures (Nguyen et al, 2000).…”

Section: Discussionmentioning

confidence: 86%

Infiltrating ductal and lobular breast carcinomas are characterised by different interrelationships among markers related to angiogenesis and hormone dependence

et al. 2002

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To obtain a more integrated understanding of the different breast cancer phenotypes and to investigate whether biomolecular profiles can distinguish between specific histotypes, we explored the interrelations among several biologic variables indicative of, or related to, hormone dependence, proliferation and apoptosis control, and angiogenesis in ductal and lobular carcinomas, the most common histotypes. Oestrogen and progesterone receptors, tumour proliferative activity, the expression of cyclin A, p16 ink4A , p27 kip1 , p21 waf1 , p53, bcl-2, and levels of vascular endothelial growth factor and hypoxia-inducible factor1a (HIF-1a) were evaluated in 190 in ductal and 67 lobular carcinomas. Our findings support the hypothesis that in ductal and lobular carcinomas are two distinct, partially phenotypically unrelated entities, the latter being characterised by the presence of features indicative of differentiation such as oestrogen receptors, low proliferation and lack of p53 expression and associated with low vascular endothelial growth factor content compared to angiogenesis in ductal carcinomas. Conversely, no significant difference was found between lobular carcinomas and in ductal carcinomas considering the frequency distribution of PgRpositive cases, cyclin-dependent kinase inhibitors acting at the G1/S boundary, bcl-2 and HIF-1a protein expression. Although both generally defined as hormone responsive, in ductal and lobular carcinomas are also characterised by biologic patterns in which proteins related to hormone responsiveness, cell-cycle control, apoptosis and angiogenesis were differently associated. This finding suggests the need to refine breast cancer characterisation in order to provide detailed information about individual tumours, or subsets of tumours, that will help in defining optimal treatment approaches.

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Section: Discussionmentioning

confidence: 86%

Infiltrating ductal and lobular breast carcinomas are characterised by different interrelationships among markers related to angiogenesis and hormone dependence

et al. 2002

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“…Consistent with these results, transgenic mice developing prostate adenocarcinoma (TRAMP) exhibit impaired metastasis when crossed into a FGF-2 knockout background [159]. Similarly, in xenotransplant and transgenic mouse models, increased tumor and/or serum levels of angiogenesis inhibitors, such as IL-10, tissue inhibitor-1 of metalloproteinases (TIMP-1), thrombospondin-1 or endostatin, reduce the incidence of metastasis [158,[160][161][162]. Yet, upregulated tumor angiogenesis may not necessarily lead to metastasis formation.…”

Section: Tumor Angiogenesismentioning

confidence: 89%

Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment

Kopfstein

Christofori

2006

Cell. Mol. Life Sci.

210

160

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Abstract. The fatality of cancer predominantly results from the dissemination of primary tumor cells to distant sites and the subsequent formation of metastases. During tumor progression, some of the primary tumor cells as well as the tumor microenvironment undergo characteristic molecular changes, which are essential for the metastatic dissemination of tumor cells. In this review, we will discuss recent insights into pro-metastatic events occurring in tumor cells themselves and in the tumor stroma. Tumor cell-intrinsic alterations include the loss of cell polarity and alterations in cell-cell and cell-matrix Cell. Mol. Life Sci. 63 (2006) 449-468 1420-682X/06/040449-20 DOI 10.1007/s00018-005-5296-8 © Birkhäuser Verlag, Basel, 2006 adhesion as well as deregulated receptor kinase signaling, which together support detachment, migration and invasion of tumor cells. On the other hand, the tumor stroma, including endothelial cells, fibroblasts and cells of the immune system, is engaged in an active molecular crosstalk within the tumor microenvironment. Subsequent activation of blood vessel and lymph vessel angiogenesis together with inflammatory and immune-suppressive responses further promotes cancer cell migration and invasion, as well as initiation of the metastatic process.

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“…Myoepithelial cells, produce high levels of proteinase inhibitors and angiogenesis inhibitors and low amounts of proteinase angiogenic factors (Nguyen et al, 2000). With respect to this evidence, Barsky and Karlin stated that myoepithelial cells are angiogenesis inhibitors (Barsky and Karlin, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…The difference in shape , size and distribution of vessels in two type of carcinoma may be explained by the characteristics of myoepithelial cells. These cells are able to produce large amounts of extracellular matrix devoid of vesseles that contains angiogenenic inhibitors (Nguyen et al, 2000). It seems that large blood vesselesin ACC are needed to compensate decreased angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

Andisheh-Tadbir¹,

Pardis²,

Ashkavandi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: To investigate the association between CD105 and tumor cell proliferation in salivary gland tumors. Methods: In this study, 59 samples of salivary tumors from Khalili Hospital archive, including 20 cases of pleomorphic adenoma (PA), 20 cases of mucoepidermoid carcinoma (MEC) and 19 cases of adenoid cystic carcinoma, as well as 10 cases of normal salivary gland tissue, were reviewed by immunohistochemistry (IHC) for CD105 and Ki67 staining. Results: CD105 positive vessels were absent in normal salivary gland tissue in the vicinity of tumors (51.6% of all tumors were positive). There was a statistically significant difference in frequency of CD105 staining between PA and malignant tumors and between four groups of different lesions (p<0.000) being highest in MEC. Intratumoral microvessel density was also elevated in malignant neoplasms (2.61±3.1) as compared to PA (0.46±0.6). Normal salivary glands did not express Ki67. There was a statistically significant difference in frequency and percentage of Ki67 immunoreactivity in malignant neoplasms (86.5% and 10.7±10.8 respectively) compared to PA (50% and 0.78±0.2) and among the four groups values were highest in MEC (p<0.000). Conclusion: n this study, it was observed a higher rate of angiogenesis and cellular proliferation was noted in malignant tumors compared to benign tumors, but no correlation was observed between these two markers.

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The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype

Cited by 78 publications

References 27 publications

Infiltrating ductal and lobular breast carcinomas are characterised by different interrelationships among markers related to angiogenesis and hormone dependence

Infiltrating ductal and lobular breast carcinomas are characterised by different interrelationships among markers related to angiogenesis and hormone dependence

Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment

Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

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