The human tumor-associated antigen RCAS1 in pregnancies complicated by pre-eclampsia

ORIGINAL ARTICLE: The Association of RCAS1 Serum Concentration with the Reversibility or Irreversibility of the Process of Immune Cytotoxic Activity Restriction During Normal Menstrual Cycle, Cancer Relapse, and Surgical Treatment for Various Types of Squamous Cell Carcinomas and Adenocarcinomas

“…has recently demonstrated a correlation between alterations in tumor size and the serum RCAS1 level in serially measured serum RCAS1 concentration in endometrial cancer patients before and after treatment 10 . Furthermore, significant changes in RCAS1 blood serum concentration levels have also been found in pre‐eclamptic patients and those patients undergoing labor—two clinical situations, where changes occur in the immune tolerance level 45,46 . The discovery of similar molecular changes in the processes that enable both trophoblast and tumor cells to escape from host immunological surveillance seems important for identifying alterations in the process of immune cytotoxic activity restriction.…”

ORIGINAL ARTICLE: Temporal and Spatial Expression of Tumor‐Associated Antigen RCAS1 in Pregnant Mouse Uterus

“…It is impossible to distinguish maternal and fetal tissue at the early stages of pregnancy. However, the placental RCAS1 protein expression is down‐regulated in some complicated pregnancies, 9,22–24 thus pointing the importance of the placental RCAS1 protein studies in pregnancies.…”

“…It is considered that RCAS1 protein may have a role in the process of placental detachment, 9 immune tolerance during pregnancy, 19–21 and stillbirth 22 . In addition, our previous studies revealed a relationship between RCAS1 protein and gestational diabetes mellitus as well as pregnancies complicated by pre‐eclampsia 23,24 . The aim of this study was to examine the temporal and spatial expression of RCAS1 protein during the time course of normal pregnancy in mice.…”

Maternal Blood Serum and Plasma Human Tumor‐Associated Antigen RCAS1 During the Course of Uncomplicated Pregnancies: A Prospective Study

“…16 Furthermore, a comparative analysis of normal placenta and neoplasms has been reported. 5 Our recent studies revealed strong connection between RCAS1 antigen and gestational diabetes mellitus, 23 pre-eclampsia, 24 and its role in the maintenance of the normal pregnancy in mice has been studied. 5 Our recent studies revealed strong connection between RCAS1 antigen and gestational diabetes mellitus, 23 pre-eclampsia, 24 and its role in the maintenance of the normal pregnancy in mice has been studied.…”

“…17 There have been several studies investigating the RCAS1 expression and immune tolerance during pregnancy, 18,19 and its connection with fetal maturity, 20 stillbirth, 21,22 the process of placental detachment. 5 Our recent studies revealed strong connection between RCAS1 antigen and gestational diabetes mellitus, 23 pre-eclampsia, 24 and its role in the maintenance of the normal pregnancy in mice has been studied. 25 The aim of this study was to assess the role of RCAS1 protein expression in maternal blood during the course of uncomplicated human pregnancies and to define its predictive value for pregnancy outcome.…”