The hypoglycemic effect of Phyllanthus sellowianus fractions in streptozotocin-induced diabetic mice

Hnatyszyn, O.; Miño, Jorge; Ferraro, Graciela; Acevedo, Cristina

doi:10.1078/09447110260573209

Cited by 32 publications

(21 citation statements)

References 13 publications

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“…Though different types of oral hypoglycemic agents are available, there is a growing trend toward using natural products as treatment (Hnatyszyn et al, 2002). China has a long history of using herbs for the treatment of human diseases and several medicinal plants are used for the treatment of diabetes.…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic activity of Selaginella tamariscina (Beauv.) Spring

Zheng

Zhang

et al. 2011

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Antihyperglycemic activity of Selaginella tamariscina (Beauv.) Spring

Zheng

Zhang

et al. 2011

Journal of Ethnopharmacology

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“…Some flavonoids such as rutin, quercetin (Figure 2A), isoorientin, 3-caffeoylquinic acid (chlorogenic acid), and silibin isoform 3 (obtained of milk thistle) have hypoglycemic properties [63][64][65][66][67].…”

Section: Flavonoidsmentioning

confidence: 99%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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■ AbstractDiabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteristic feature of diabetes is hyperglycemia, which reflects the deterioration in the use of glucose due to a faulty or poor response to insulin secretion. Alloxan and streptozotocin (STZ) are the chemical tools that are most commonly used to study the disease in rodents. Many plant species have been used in ethnopharmacology or to treat experimentally symptoms of this disease. When evaluated pharmacologically, most of the plants employed as antidiabetic substances have been shown to exhibit hypoglycemic and antihyperglycemic activities, and to contain chemical constituents that may be used as new antidiabetic agents. There are many substances extracted from plants that offer antidiabetic potential, whereas others may result in hypoglycemia as a side effect due to their toxicity, particularly their hepatotoxicity. In this article we present an updated overview of the studies on extracts from medicinal plants, relating the mechanisms of action by which these substances act and the natural principles of antidiabetic activity.

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“…Plants have always been an exemplary source of drugs and herbal drugs which have been investigated all over the world to treat diabetes [15,16] . Till today more than 1 200 species of plants have been screened for activity on the basis of traditional knowledge [17] .…”

Section: Introductionmentioning

confidence: 99%