The hypothalamus may mediate migraine and ictal photophobia: evidence from Granger causality analysis

Zhang, Luping; Yu, Wenjing; Xu, Maosheng; Cui, Feng; Song, Wenwen; Yan, Minli; Cao, Zhijian; Zhang, Zhengxiang

doi:10.1007/s10072-022-06245-y

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…Profoundly prolonged duration and recurrently attacked headache are the main complaints of migraine suffers ( 51 ). Thalamus is thought to have an essential role in the pathophysiology of migraine and has been investigated extensively ( 52 – 55 ). Meanwhile, the migraine genesis is more likely within brainstem, involving dysfunction and plasticity changes ( 56 ).…”

Section: Discussionmentioning

confidence: 99%

The brain structure and function abnormalities of migraineurs: A systematic review and neuroimaging meta-analysis

et al. 2022

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ObjectivesTo quantitatively summarize the specific changes in brain structure and function in migraine patients.MethodsA literature screening of migraine was conducted from inception to Sept 1, 2022, in PubMed, Web of Science, Cochrane Library, and Medline databases using the keyword combination of “migraine and MRI.” Activation likelihood estimation (ALE) was performed to assess the differentiation of functional connectivity (FC), regional homogeneity (ReHo), and gray matter volume (GMV) of migraine patients.ResultsEleven voxel-based morphometry (VBM) studies and 25 resting-state fMRI (rs-fMRI) studies (16 FC and 9 ReHo studies) were included in this study. ALE analysis revealed the ReHo increase in the brainstem and left thalamus, with no decreased area. Neither increased nor decreased regions were detected in FC and GMV of migraine patients.ConclusionsThe left thalamus and brainstem were the significantly activated regions of migraine. It is a meaningful insights into the pathophysiology of migraine. The consistent alterated brain areas of morphometrical and functional in migraine patients were far from reached based on current studies.

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Section: Discussionmentioning

confidence: 99%

The brain structure and function abnormalities of migraineurs: A systematic review and neuroimaging meta-analysis

et al. 2022

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Altered brain activity and functional connectivity in migraine without aura during and outside attack

Zhang

et al. 2023

Neurological Research

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Altered Effective Connectivity of the Pain Matrix in Herpes Zoster and Postherpetic Neuralgia Patients: Granger Causality Analysis of Resting-State fMRI

Lv,

Gu,

Xiong

et al. 2024

J. Integr. Neurosci.

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Background: Shingles can cause long-term pain and negative emotions, along with changes in brain function. In this study, Granger Causality Analysis (GCA) was used to compare herpes zoster (HZ) and postherpetic neuralgia (PHN) differences in effective connections within the “pain matrix” between patients and healthy controls to further understand patterns of interaction between brain regions and explore the relationship between changes in effective connections and clinical features. Methods: Resting-state functional magnetic resonance imaging (fMRI) scans were performed on 55 HZ; 55 PHN; and 50 age-, sex- matched healthy controls (HCs). The brain regions associated with the pain matrix are used as the seeds of effective connectivity. GCA was used to analyze effective connections in brain regions that differed significantly between groups. Then the correlation between GCA values and clinical indicators was studied. Results: Compared with HC, GCA values between the thalamus and the amygdala, between the thalamus and the precentral gyrus, from the thalamus to the postcentral gyrus, and from the parahippocampal gyrus to the amygdala, anterior cingulate gyrus were significantly reduced in HZ patients. Compared with HC, GCA values between the insular and the postcentral gyrus, from the insular to the inferior parietal lobe, and from the postcentral gyrus to the amygdala were significantly reduced in PHN patients. Compared with HZ, GCA values between the inferior parietal lobe and the parahippocampal gyrus, between the inferior parietal lobe and the anterior cingulate gyrus, and from the anterior cingulate gyrus to the amygdala were significantly increased in PHN patients. The visual analogue scale (VAS) score of PHN patients was positively correlated with the GCA value from the central posterior lobe to the insula. Conclusions: PHN and HZ patients showed a broad reduction in effective connections, mainly reflected in abnormal pain pathway regulation, pain perception, negative emotion and memory production, providing new perspectives to understand the neuroimaging mechanisms of shingles.

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The hypothalamus may mediate migraine and ictal photophobia: evidence from Granger causality analysis

Cited by 3 publications

References 61 publications

The brain structure and function abnormalities of migraineurs: A systematic review and neuroimaging meta-analysis

The brain structure and function abnormalities of migraineurs: A systematic review and neuroimaging meta-analysis

Altered brain activity and functional connectivity in migraine without aura during and outside attack

Altered Effective Connectivity of the Pain Matrix in Herpes Zoster and Postherpetic Neuralgia Patients: Granger Causality Analysis of Resting-State fMRI

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