The
            <i>Cryptosporidium</i>
            “Mouse” Genotype Is Conserved across Geographic Areas

Morgan, U.M.; Sturdee, A. P.; Singleton, Grant R.; Gómez, M. S.; Gracenea, Mercedes; Torres, Jordi; Hamilton, Steven G.; Woodside, D. P.; Thompson, R.C.A.

doi:10.1128/jcm.37.5.1302-1305.1999

Cited by 69 publications

(23 citation statements)

References 22 publications

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“…Six isolates recovered were identified as C. parvum; all hosts were rodents and included five deer mice and one red-backed vole. The identification of zoonotic isolates of Cryptosporidium has been previously reported from house mice (Morgan et al, 1999) and Eastern chipmunks (Perz and Le Blancq, 2001). As the exchange of these pathogens between cattle and wildlife have become of increasing interest, the issue of pseudoinfection in either population is an important factor to consider.…”

Section: Discussionmentioning

confidence: 99%

Cryptosporidium Spp. From Small Mammals in the New York City Watershed

Ziegler

Wade

Schaaf

et al. 2007

Journal of Wildlife Diseases

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The objective of this study was to assess the potential role that wildlife plays in environmental degradation of watersheds through the contamination of the water supply with zoonotic genotypes of Cryptosporidium. Cryptosporidium isolates recovered from wildlife in the New York City (NYC) watershed were examined to determine genotype using a polymerase chain reaction protocol targeting the 18-Small Subunit (SSU) rRNA locus. Seventy-seven DNA samples recovered from 12 wildlife host species captured in the NYC watershed were amplified and sequenced. Data on risk factors associated with the perpetuation of these genotypes also were collected and analyzed. Although many genotypes appeared to be host-specific, 38% of the samples examined were identified as Cryptosporidium parvum, indicating the presence of zoonotic Cryptosporidium. Adult animals were more likely to shed the zoonotic strains of Cryptosporidium spp. Animals captured in the fall and winter were more likely to be infected with C. parvum than those captured in spring and summer.

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Section: Discussionmentioning

confidence: 99%

Cryptosporidium Spp. From Small Mammals in the New York City Watershed

Ziegler

Wade

Schaaf

et al. 2007

Journal of Wildlife Diseases

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“…Refs* ; 2, Singleton et al (2000); 3, Singleton et al (1993); 4, Smith et al (1993); 5, Taylor et al (1994); 6, Singleton (1985); 7, Singleton & Redhead (1990); 8, Angel & Mutze (1987); 9, Gordon (1997); 10, Morgan et al (1999). †MVM, minute virus of mice; MPV, mouse parvovirus.…”

Section: Parasitementioning

confidence: 99%

One hundred years of eruptions of house mice in Australia - a natural biological curio

Singleton

Brown

Pech

et al. 2005

Biological Journal of the Linnean Society

555

114

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The house mouse has adapted well to the cereal crops of south-eastern Australia where populations show aperiodic outbreaks over large areas. A 20-year population study has provided a wealth of information on breeding ecology, demographic changes, spatial behaviour and epidemiology. The breeding season can be as short as 4.5 months and as long as 10 months with litter size changing seasonally from high values in spring to low values in autumn. There are marked changes in litter size between years. Rates of increase of populations also vary between years. The rate of change of populations during the breeding season is independent of density effects, but if the population density is high at the commencement of breeding then the litter size is depressed throughout that breeding season. There are density-dependent effects on survival during the non-breeding season. Rates of increase of populations over spring and summer are highly correlated with accumulated rainfall from the previous winter-spring (

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“…Genetic characterizations of Cryptosporidium specimens from various animals, however, have mostly failed to detect this parasite in wild mammals (Zhou et al , 2004b; Feng et al , 2007a). It is now generally accepted that C. parvum (referred to previously as the bovine genotype) primarily infects ruminants and humans, even though natural infections have been found occasionally in other animals such as mice and raccoon dogs (Morgan et al , 1999b; Matsubayashi et al , 2004).…”

Section: Introductionmentioning

confidence: 99%

Zoonotic cryptosporidiosis

Xiao

Feng

2008

FEMS Immunology &Amp; Medical Microbiology

317

244

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The widespread usages of molecular epidemiological tools have improved the understanding of cryptosporidiosis transmission. Much attention on zoonotic cryptosporidiosis is centered on Cryptosporidium parvum. Results of genotype surveys indicate that calves are the only major reservoir for C. parvum infections in humans. The widespread presence of human-adapted C. parvum, especially in developing countries, is revealed by recent subtyping and multilocus typing studies, which have also demonstrated the anthroponotic transmission of C. parvum subtypes shared by humans and cattle. Developing and industrialized countries differ significantly in disease burdens caused by zoonotic species and in the source of these parasites, with the former having far fewer human infections caused by C. parvum and little zoonotic transmission of this species. Exclusive anthroponotic transmission of seemingly zoonotic C. parvum subtypes was seen in Mid-Eastern countries. Other zoonotic Cryptosporidium spp. are also responsible for substantial numbers of human infections in developing countries, many of which are probably transmitted by anthroponotic pathways. The lower pathogenicity of some zoonotic species in some populations supports the occurrence of different clinical spectra of Cryptosporidium spp. in humans. The use of a new generation of molecular diagnostic tools is likely to produce a more complete picture of zoonotic cryptosporidiosis.

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The Cryptosporidium “Mouse” Genotype Is Conserved across Geographic Areas

Cited by 69 publications

References 22 publications

Cryptosporidium Spp. From Small Mammals in the New York City Watershed

Cryptosporidium Spp. From Small Mammals in the New York City Watershed

One hundred years of eruptions of house mice in Australia - a natural biological curio

Zoonotic cryptosporidiosis

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