The IARC Perspective on Colorectal Cancer Screening

Baglioni, Piero

doi:10.1056/nejmc1807173

Cited by 14 publications

(3 citation statements)

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“…The cecum and colon are the main regions of the conversion of primary BAs into more than 20 secondary BAs through an extensive microbial process ( 37 ). The peristaltic velocity of the GIT is related to the production of 5-hydroxytryptamine by the microbiota in the colon, so there is a bidirectional communication between the host and the microbiota in the colon ( 38 , 39 ). Our results also show that the metabolism of secondary metabolites, energy metabolism, cell growth, and death are the main functions of microbiota in the colon.…”

Section: Discussionmentioning

confidence: 99%

The Lumenal Microbiota Varies Biogeographically in the Gastrointestinal Tract of Rhesus Macaques

et al. 2022

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Section: Discussionmentioning

confidence: 99%

The Lumenal Microbiota Varies Biogeographically in the Gastrointestinal Tract of Rhesus Macaques

et al. 2022

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“…It has the third highest mortality rate from cancer with over 900,000 deaths annually. Bowel cancer screening programmes worldwide have been able to achieve a reduction in incidence and mortality [2]. Identification of premalignant lesions through screening has helped in reducing the incidence while early identification of cancer has improved overall survival from CRC [2].…”

Section: Introductionmentioning

confidence: 99%

“…Bowel cancer screening programmes worldwide have been able to achieve a reduction in incidence and mortality [2]. Identification of premalignant lesions through screening has helped in reducing the incidence while early identification of cancer has improved overall survival from CRC [2]. A recent rise in the incidence of early-onset colorectal cancers [EOCRC] has been reported globally.…”

Section: Introductionmentioning

confidence: 99%

Trends in early onset colorectal cancer (EOCRC) in a South Asian cohort: data from a specialized tertiary care center in western Sri Lanka

et al. 2022

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IntroductionEarly onset colorectal cancer [EOCRC] has significantly increased during the past decade globally. It is defined as cancers diagnosed in those aged 50 years or less. Most research on EORC are from western populations where the tumour biology and risk factors may differ from other regions. Evidence on EOCRC from the South Asian region is particularly scarce. This study presents the basic trends in presentation and overall survival [OS] pattern of EOCRC using data from a single specialized tertiary care institution over two decades. MethodsA total of 723 patients treated at the University surgical unit of the North Colombo teaching hospital from 1995 to 2020 were included in the analysis. Overall survival of the EOCRC was compared with that of the older population using Kaplan-Meier survival curves. Survival patterns over two time periods [pre-2010 vs post-2010] were also compared between the two populations. The stage at presentation, family history of colorectal or related cancers, tumour site, and tumour stage were also compared. ResultsThe proportion of EOCRC in this cohort has not shown a significant increase over the past two decades [2001-2010: 24% vs 2011-2020: 21%]. The advanced tumour stage at presentation and the presence of significant family history are also comparable. EOCRC cohort demonstrates a better OS for the entire study period [Median survival: < 50 years -not reached; >50 years -91 months; 95%CI -72-132; P<0.001]. However, this survival advantage is only observed during the pre-2010 period [Median survival: < 50 years -160 months; 95%CI -120 -not reached; >50 years -84 months; 95%CI -62-132; P=0.01] and becomes comparable in the 2010-2020 period [P=0.16]. OS of the EORC has not also improved over the two decades from 2001 to 2020 [P=0.51].

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Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites

et al. 2021

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The microbiome has a fundamental impact on the human host's physiology through the production of highly reactive compounds that can lead to disease development. One class of such compounds are carbonyl‐containing metabolites, which are involved in diverse biochemical processes. Mass spectrometry is the method of choice for analysis of metabolites but carbonyls are analytically challenging. Herein, we have developed a new chemical biology tool using chemoselective modification to overcome analytical limitations. Two isotopic probes allow for the simultaneous and semi‐quantitative analysis at the femtomole level as well as qualitative analysis at attomole quantities that allows for detection of more than 200 metabolites in human fecal, urine and plasma samples. This comprehensive mass spectrometric analysis enhances the scope of metabolomics‐driven biomarker discovery. We anticipate that our chemical biology tool will be of general use in metabolomics analysis to obtain a better understanding of microbial interactions with the human host and disease development.

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The IARC Perspective on Colorectal Cancer Screening

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Cited by 14 publications

References 35 publications

The Lumenal Microbiota Varies Biogeographically in the Gastrointestinal Tract of Rhesus Macaques

The Lumenal Microbiota Varies Biogeographically in the Gastrointestinal Tract of Rhesus Macaques

Trends in early onset colorectal cancer (EOCRC) in a South Asian cohort: data from a specialized tertiary care center in western Sri Lanka

Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites

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