The identification and localization of a catecholamine in the motor neurons of the lobster cardiac ganglion

Ocorr, Karen; Berlind, Allan

doi:10.1002/neu.480140107

Cited by 30 publications

(11 citation statements)

References 25 publications

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“…This suggests that the labeled cells contained DA rather than norepinephrine (NE) or epinephrine, both of which are synthesized from DA. Some reports have indicated that NE and epinephrine do not occur in crustacean neural tissue (Barker et al, 1979;Cooke and Sullivan, 1982); however, other investigations did detect NE in the crayfish central nervous system (Elofsson et al, 1982;Fingerman and Kulkarni, 1993;Ocorr and Berlind, 1983). Also, Schmidt andAche (1994, 1997) found that their DA antibody cross-reacted with NE such that NE (10 Ϫ4 M) preabsorption of the DA antibody caused a loss of DA immunoreactivity in crustacean tissue.…”

Section: Introductionmentioning

confidence: 89%

“…The rhythmic activity of CG neurons is, in turn, modulated by acceleratory and inhibitory axons that project from the subesophageal ganglion and by neurohormones released from the pericardial organs (Field and Larimer, 1975;Wilkens, 1995). In addition to its action as a pericardial neurohormone, DA may function as a neurotransmitter released by cardioaccelerator axons at synapses between these cells and CG neurons Kuwasawa, 1992, 1994), or as an intrinsic neurotransmitter within the CG (Ocorr and Berlind, 1983). To date, most investigations have focused on the effects of DA on the heart via changes in CG output, though direct effects of the amine on the myocardium and cardioarterial valves may also be important in cardiovascular regulation (Wilkens et al, 1996).…”

Section: Cardiovascular Systemmentioning

confidence: 97%

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Dopamine in crayfish and other crustaceans: Distribution in the central nervous system and physiological functions

Tierney

Kim

Abrams

2003

Microscopy Res & Technique

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Dopamine is widely distributed in the crustacean nervous system and has a diverse array of physiological effects. Immunocytochemical studies of several species have shown that dopamine- and/or tyrosine hydroxylase-containing cells occur in all ganglia of the central nervous system and that processes from some of these cells link ganglia of the ventral nerve cord. This study describes the distribution of tyrosine hydroxylase-containing cells in the central nervous system of a crayfish (Orconectes rusticus) and compares this information to available data from other species. The distribution of tyrosine hydroxylase (an enzyme in the synthetic pathway between tyrosine and dopamine) in O. rusticus is similar to that reported for marine species. However, differences were observed in the number of neurons in some ganglia and in the axonal projections of the L cell, which were more extensive in O. rusticus than in other species studied thus far. We also review the physiological effects of dopamine in crayfish and other crustaceans, focusing on the amine's actions in the endocrine, cardiovascular, and nervous systems, and on behavior when injected into freely-moving animals.

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Section: Introductionmentioning

confidence: 89%

Section: Cardiovascular Systemmentioning

confidence: 97%

Dopamine in crayfish and other crustaceans: Distribution in the central nervous system and physiological functions

Tierney

Kim

Abrams

2003

Microscopy Res & Technique

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“…7; see also Yazawa and Kuwasawa 1994). The presence of dopamine within these fibers may account for earlier biochemical measurements of catecholamines in the lobster cardiac ganglion (Ocorr and Berlind 1983). The localization of THli does not support a role for dopamine as the neurotransmitter of the motor neurons, a function for which L-glutamate is currently a leading candidate (Benson 1981;Cooke 1966;Delgado et al 2000;Yazawa et al 1998).…”

Section: Catecholaminergic Innervation Of the Cardiac Systemmentioning

confidence: 98%

Modulation of an Integrated Central Pattern Generator–Effector System: Dopaminergic Regulation of Cardiac Activity in the Blue CrabCallinectes sapidus

Fort

Březina²,

Miller³

2004

Journal of Neurophysiology

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Fort, Timothy J., Vladimir Brezina, and Mark W. Miller. Modulation of an integrated central pattern generator-effector system: dopaminergic regulation of cardiac activity in the blue crab Callinectes sapidus. J Neurophysiol 92: 3455-3470, 2004; doi:10.1152/ jn.00550.2004. Theoretical studies have suggested that the output of a central pattern generator (CPG) must be matched to the properties of its peripheral effector system to ensure production of functional behavior. One way that such matching could be achieved is through coordinated central and peripheral modulation. In this study, morphological and physiological methods were used to examine the sources and actions of dopaminergic modulation in the cardiac system of the blue crab, Callinectes sapidus. Immunohistochemical localization of tyrosine hydroxylase (TH) revealed a prominent neuron in the commissural ganglion, the L-cell, that projected a large-diameter axon to the pericardial organ (PO) by an indirect and circuitous route. Within the PO, the L-cell axon gave rise to fine varicose fibers, suggesting that it releases dopamine in a neurohormonal fashion onto the heart musculature. In addition, one branch of the axon continued beyond the PO to the heart, where it innervated the anterior motor neurons and the posterior pacemaker region of the cardiac ganglion (CG). In physiological experiments, exogenous dopamine produced multiple effects on contraction and motor neuron burst parameters that corresponded to the dual central-peripheral modulation suggested by the L-cell morphology. Interestingly, parameters of the ganglionic motor output were modulated differently in the isolated CG and in a novel semiintact system where the CG remained embedded within the heart musculature. These observations suggest a critical role of feedback from the periphery to the CG and underscore the requirement for integration of peripheral (neurohormonal) actions and direct ganglionic modulation in the regulation of this exceptionally simple system.

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“…5) Dopamine decreases membrane resistance of LGCs and myocardial cells (T. u and K. Kuwasawa, unpublished observations). Dopamine has been detected by HPLC in the cardiac ganglion in Homarus (Ocorr and Berlind 1983). Sullivan et al (1977) reported that in Panulirus interruptus the dorsal nerve apparatus accumulated nearly half as much dopamine as octopamine, whereas in the ligamental nerve plexuses the range was from 3.4-5.3%.…”

Section: Acceleratory Nervesmentioning

confidence: 99%

Dopaminergic acceleration and GABAergic inhibition in extrinsic neural control of the hermit crab heart

Yazawa

Kuwasawa

1994

J Comp Physiol A

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The acceleratory and inhibitory cardio-regulatory nerves of hermit crabs (Aniculus aniculus, Dardanus crassimanus) were studied using histochemical, immunocytochemical and pharmacological tests. Glyoxylic acidinduced fluorescence was observed in two of three axons of the dorsal cardiac nerve. One axon of the nerve showed gamma-aminobutyric acid-like immunoreactivity. Effects of stimulation of cardio-acceleratory axons were blocked by the dopaminergic antagonists, haloperidol and chlorpromazine, but not by cholinergic, adrenergic or serotonergic blockers, suggesting that dopamine is the primary potential candidate for the neurotransmitter of cardio-accelerator neurons. Picrotoxin antagonized inhibition of the cardiac ganglion induced by gammaaminobutyric acid and by cardio-inhibitory axons. Both small and large ganglionic cells may receive dopaminergic and GABAergic extrinsic neural control.

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The identification and localization of a catecholamine in the motor neurons of the lobster cardiac ganglion

Cited by 30 publications

References 25 publications

Dopamine in crayfish and other crustaceans: Distribution in the central nervous system and physiological functions

Dopamine in crayfish and other crustaceans: Distribution in the central nervous system and physiological functions

Modulation of an Integrated Central Pattern Generator–Effector System: Dopaminergic Regulation of Cardiac Activity in the Blue CrabCallinectes sapidus

Dopaminergic acceleration and GABAergic inhibition in extrinsic neural control of the hermit crab heart

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