The IL-33-ST2L Pathway Is Associated with Coronary Artery Disease in a Chinese Han Population

Tu, Xin; Nie, Shaofang; Liao, Yuhua; Zhang, Hongsong; Fan, Qian; Xu, Chengqi; Bai, Ying; Wang, Fan; Ren, Xiang; Tang, Tingting; Xia, Ni; Li, Sisi; Huang, Yuan; Liu, Juan; Yang, Qing; Zhao, Yuanyuan; Lv, Qiulun; Li, Qingxian; Li, Yue; Qian, Jin; Li, Bin; Wu, Gang; Wu, Yanxia; Yang, Yan; Wang, Qing Kenneth; Cheng, X.

doi:10.1016/j.ajhg.2014.01.013

Cited by 7 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Together, this suggests these variants may influence EH susceptibility by controlling their own expression. Previous studies have confirmed this, and shown that rs11685424 and rs6543116 are associated with elevated EH risk and increased sST2 expression [19,22]. As noted, rs3821204 disrupts a putative miRNA binding site; therefore we predicted that this variant controls ST2 expression via a mechanism that is distinct compared with the three other SNPs.…”

Section: Association Between St2 Variants and Eh Risksupporting

confidence: 70%

“…In this case–control study, we found that the rs11685424 and rs6543116 genetic variations within the ST2 promoter region are associated with EH risk. These two variants modify transcriptional activity of the ST2 promoter . Thus, it is likely that the biological consequence of these genetic variants may influence EH susceptibility.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it is likely that the biological consequence of these genetic variants may influence EH susceptibility. Recently, Tu and Tsapaki reported association between ST2 variants and CHD . To minimize this disturbance, we re‐analysed association between ST2 variants and EH risk in subgroups without CHD.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A functional variant in ST2 gene is associated with risk of hypertension via interfering MiR‐202‐3p

Wen

et al. 2017

J Cellular Molecular Medi

View full text Add to dashboard Cite

Recent studies have suggested that interleukin 1 receptor‐like 1 (ST2) plays a critical role in pathogenesis of several cardiovascular disease conditions. In this study, we examined association of 13 single nucleotide polymorphisms (SNPs) of ST2 gene with essential hypertension (EH) risk in 1151 patients with EH and 1135 controls. Our study showed that variants rs11685424, rs12999364 and rs3821204 are highly associated with an increase in risk of EH, while rs6543116 is associated with a decrease risk of EH. Notably, in silico analyses suggested the G>C change of rs3821204, which located within the 3′UTR of soluble ST2 mRNA, disrupted a putative binding site for miR202‐3p. Functional analyses suggested that miR‐202‐3p significantly decreased soluble ST2‐G mRNA stability and inhibited its endogenous expression. Furthermore, we found increased plasma‐soluble ST2 (sST2) level was highly associated with CC genotype of rs3821204 in vivo. Taken together, our findings provide the first evidence that genetic variants in ST2 gene are associated with EH risk and variant rs3821204 may influence the development of EH by controlling sST2 expression.

show abstract

Section: Association Between St2 Variants and Eh Risksupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A functional variant in ST2 gene is associated with risk of hypertension via interfering MiR‐202‐3p

Wen

et al. 2017

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Previous data have demonstrated the association between the distal promoter variants in ST2 and angiographic severity of CAD, and suggest that the IL-33/ST2L pathway might be genetically associated with CAD [22] . Moreover, IL33/ST2 pathway was significantly associated not only with patients with severe coronary stenosis, but with the subgroup of MI or revascularization, and affected the level of circulating IL-33 genetically [23] . Our study found no associations between the three kinds of SNPs and MI after adjustment for hypertension and DM.…”

Section: Discussionmentioning

confidence: 98%

Association of IL33/ST2 signal pathway gene polymorphisms with myocardial infarction in a Chinese Han population

Yang

Wen

et al. 2015

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

View full text Add to dashboard Cite

This study investigated the relationship between IL-33/ST2 signal pathway gene polymorphisms and myocardial infarction (MI) in Han Chinese. A case-control association analysis was performed on a total of 490 MI patients (MI group) and 929 normal subjects (NC group). Sequenom Mass Array and Taqman genotyping technique were used to analyze the tag single nucleotide polymorphisms (SNPs) in the genes encoding IL-33, ST2, and IL-1RaP (rs11792633, rs1041973 and rs4624606). The results showed that the frequencies of rs4624606 genotypes AA, TT, AT were 0.031, 0.647, 0.322 in MI group and 0.026, 0.712, 0.263 in NC group, and the allele frequencies of A and T were 0.192, 0.808 in MI group and 0.157, 0.843 in NC group. There were significant differences in rs4624606 genotypes and allele frequencies between MI group and NC group (P<0.05). For rs11792633, the allele frequencies of C and T were 0.45, 0.55 in MI group and 0.454, 0.546 in NC group with no significant differences found between the two groups. Compared with genotype CC+TC, rs11792633 genotype TT had an increased risk of hypertension (P<0.05). However, there were no significant differences in the frequencies of rs11792633 genotypes between the two groups. No significant differences were noted in the frequencies of rs1041973 genotype and allele between the two groups. Logistic regression analysis showed that rs4624606 genotypes AT and AA+AT were both significantly associated with MI (AT: OR=1.325, P=0.029, 95% CI=1.03-1.705; AA+AT: OR=1.316, P=0.028, 95% CI=1.03-1.681) after factors such as age, gender, smoking, drinking, body mass index (BMI), triglyceride (TG) and cholesterol were adjusted. Those carrying rs4624606 genotype AT or AA+AT had an increased risk of MI. No associations were found between the polymorphisms of the other two loci with MI. It was concluded that, in the IL33/ST2 signal pathway, the A allele of rs4624606 polymorphism of IL-1RaP gene is a potential independent risk factor for MI, and the genotypes AA+AT and AT are associated with the incidence of MI.

show abstract

“…Most of them, however, are located in the intron of IL‐33 and have no function. In this study, we focused on a functional polymorphism rs7025417 that are located in the promoter of IL‐33 (−1611 bp from the transcription start site), with the different genotypes affecting the levels of circulating IL‐33 . Because IL‐33 exerts functions via ST2, another SNP rs3821204 was selected, which was located within the 3′ untranslated region (UTR) of ST2 mRNA.…”

Section: Introductionmentioning

confidence: 99%

Association between functional polymorphisms in IL‐33/ST2 pathway and risk of osteosarcoma

Wang

Liu

Xie

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

Interleukin (IL)‐33/ST2 pathway plays crucial roles in tumour growth and metastasis. The aim of this study was to investigate the association of two functional polymorphisms (IL‐33 rs7025417 and ST2 rs3821204) with osteosarcoma (OS) risk. The rs7025417 and rs3821204 were genotyped by Taqman assay. IL‐33 mRNA and protein levels were measured by real‐time PCR or enzyme‐linked immunosorbent assay. The luciferase activity was measured by a dual luciferase reporter gene assay. The allele‐specific transcription factor binding for rs7025417 was examined by ChIP‐seq. The IL‐33 rs7025417 CC genotype was significantly associated with a decreased risk of OS (CC vs TT: OR = 0.59, 95% CI, 0.41‐0.85; recessive model: OR = 0.68, 95% CI, 0.49‐0.94; C vs T: OR = 0.76, 95% CI, 0.63‐0.91). Combined analysis showed that the IL‐33 rs7025417CT/CC‐ST2 rs3821204CG/CC and the IL‐33 rs7025417CT/CC‐ST2 rs3821204GG genotypes also had a decreased risk of OS. IL‐33 mRNA and protein levels in OS patients were significantly higher than controls. Patients with the rs7025417 CC genotype exhibited lower levels of IL‐33 (P = .03). The rs7025417 C allele presented a lower transcriptional activity by disrupting the binding site to c‐Myb (P < .01). Moreover, the rs3821204 G/C influences the transcriptional activity and ST2 mRNA expression by altering the binding site of miR‐202‐3p. These findings suggest that the rs7025417 and rs3821204 may have a combined effect to protect against the development of OS by decreasing the expression levels of IL‐33 or ST2.

show abstract

The IL-33-ST2L Pathway Is Associated with Coronary Artery Disease in a Chinese Han Population

Cited by 7 publications

References 0 publications

A functional variant in ST2 gene is associated with risk of hypertension via interfering MiR‐202‐3p

A functional variant in ST2 gene is associated with risk of hypertension via interfering MiR‐202‐3p

Association of IL33/ST2 signal pathway gene polymorphisms with myocardial infarction in a Chinese Han population

Association between functional polymorphisms in IL‐33/ST2 pathway and risk of osteosarcoma

Contact Info

Product

Resources

About