The imaging of local glucose levels in tumor periphery <i>via</i> peroxyoxalate chemiluminescent nanoparticle–glucose oxidase–doped alginate hydrogel

Li, Zengjin; Zhu, Beibei; Duan, Xinrui; Tang, Wei

doi:10.1039/c9ay00625g

Cited by 16 publications

(19 citation statements)

References 30 publications

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“…POCL has been used in literature frequently in nanoparticle and hydrogel preparations. Li et al (2019) developed a POCL nanoparticle -glucose oxidase-doped alginate hydrogel, in order to determine glucose levels in the tumor periphery to study tumor metabolism. Following glucose permeation into the system, it will be oxidized by glucose oxidase to produce H 2 O 2 , which will be detected by peroxyoxalate.…”

Section: Peroxyoxalic Acid and Their Derivativesmentioning

confidence: 99%

“…Following glucose permeation into the system, it will be oxidized by glucose oxidase to produce H 2 O 2 , which will be detected by peroxyoxalate. Following subcutaneous injection of the solution into CT-26 tumor bearing mice, the gel allowed localization of the nanoparticles to provide a high signal-to-noise ratio at the tumor site (Li et al, 2019).…”

Section: Peroxyoxalic Acid and Their Derivativesmentioning

confidence: 99%

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Ultrasound-Enhanced Chemiluminescence for Bioimaging

Dhamecha

Gonsalves

et al. 2020

Front. Bioeng. Biotechnol.

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Tissue imaging has emerged as an important aspect of theragnosis. It is essential not only to evaluate the degree of the disease and thus provide appropriate treatments, but also to monitor the delivery of administered drugs and the subsequent recovery of target tissues. Several techniques including magnetic resonance imaging (MRI), computational tomography (CT), acoustic tomography (AT), biofluorescence (BF) and chemiluminescence (CL), have been developed to reconstruct three-dimensional images of tissues. While imaging has been achieved with adequate spatial resolution for shallow depths, challenges still remain for imaging deep tissues. Energy loss is usually observed when using a magnetic field or traditional ultrasound (US), which leads to a need for more powerful energy input. This may subsequently result in tissue damage. CT requires exposure to radiation and a high dose of contrast agent to be administered for imaging. The BF technique, meanwhile, is affected by strong scattering of light and autofluorescence of tissues. The CL is a more selective and sensitive method as stable luminophores are produced from physiochemical reactions, e.g. with reactive oxygen species. Development of near infrared-emitting luminophores also bring potential for application of CL in deep tissues and whole animal studies. However, traditional CL imaging requires an enhancer to increase the intensity of low-level light emissions, while reducing the scattering of emitted light through turbid tissue environment. There has been interest in the use of focused ultrasound (FUS), which can allow acoustic waves to propagate within tissues and modulate chemiluminescence signals. While light scattering is decreased, the spatial resolution is increased with the assistance of US. In this review, chemiluminescence detection in deep tissues with assistance of FUS will be highlighted to discuss its potential in deep tissue imaging.

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Section: Peroxyoxalic Acid and Their Derivativesmentioning

confidence: 99%

Section: Peroxyoxalic Acid and Their Derivativesmentioning

confidence: 99%

Ultrasound-Enhanced Chemiluminescence for Bioimaging

Dhamecha

Gonsalves

et al. 2020

Front. Bioeng. Biotechnol.

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“…Theg el was used for quantitative in vitro detection of glucose and subsequently for in vivo imaging of tumour tissues by injecting the hydrogel into the tumour periphery. [75] An alternative methodt oe ncapsulate peroxyoxalate was demonstrated by Jie et al by synthesising hydrophilic mesoporouss ilica particles doped with CPPO and ad ye. The electrostatically adsorbed oxidasec atalyses the production of peroxidea nd further protects the peroxyoxalate from degradation.…”

Section: In Vivo Detection Of Glucosementioning

confidence: 99%

“…b) The mechanism of chemically ignited fluorescence reaction occurring in PO-CL nanoparticles. c) Schematic representation of the components of PO-CL nanoparticles and the detection of glucose by PO-CL-GOx-alginate/Ca gel system.R eproduced from Ref [75]. with kind permission from the Royal Society of Chemistry, Copyright 2019.Scheme5.The two-step process of a) H 2 O 2 generation and scavenging in the peroxisome and b) the peroxisome-like chemiluminescentnano device.…”

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confidence: 99%

All Eyes on Visible‐Light Peroxyoxalate Chemiluminescence Read‐Out Systems

Delafresnaye

Bloesser

Kockler

et al. 2019

Chemistry A European J

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Chemiluminescence (CL) reactions have been widely employed and explored over the past 50 years because they offer unique light emission upon a defined chemical stimulus. In this Minireview, we focus on peroxyoxalate (PO) compounds because they feature very high quantum yields tuneable over the entire visible spectrum, allowing for visible‐light detection by the naked eye without the necessity for expensive analytical instruments. Although analytical methods have been extensively described, PO‐CL read‐out is a strongly emerging field with ample industrial potential. The state‐of‐the‐art PO‐CL detection read‐out systems for various key analytes is here explored. In particular, structural requirements, recent developments of PO‐CL read‐out probes and current limitations of selected examples are detailed. Furthermore, innovative approaches and synthetic routes to push the boundaries of PO‐CL reactions into biological systems are highlighted. Underpinned by recent contributions, we share perspectives on embedding PO‐CL molecules into polymeric materials, which they consider the next step in designing high performance solid‐phase read‐out systems.

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“…Pilar et al ( 2018 ) considered that an aqueous solution of gold nanoparticles can improve the efficiency in electrogenerated chemiluminescent reactions. Li et al ( 2019 ) applied the imaging of local glucose levels in tumor periphery via peroxyoxalate chemiluminescent nanoparticle–glucose oxidase–doped alginate hydrogel.…”

Section: Introductionmentioning

confidence: 99%

Development of an Approach of High Sensitive Chemiluminescent Assay for Cystatin C Using a Nanoparticle Carrier

Sun

Tao

et al. 2020

Front. Chem.

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Cystatin C is an important cysteine protease inhibitor in the human body and is proposed as a new indicator of glomerular filtration rate for the detection of kidney damage. In this article, we report an ultra-sensitive, simple, and rapid chemiluminescence immunoassay method for cystatin C detection using functionalized mesoporous silica nanoparticles. After a three step hydrolysis, the amino-functionalized MSN encapsulating dye resulted in a hydrophobic environment for fixing the dye and amino groups for biological modification. The NaIO 4 immobilization method maintained the activity of the antibody notably well. The sandwich immunoassay using two monoclonal antibodies was chosen for its selectivity. The analysis demonstrated that the detection upper was 0.0029 ng/mL and linear relationship within the range of 0.0035–0.5 ng/mL ( R 2 = 0.9936). The relative standard deviation (RSD) for 11 parallel measurements of 0.25 ng/mL CysC was 4.7%. The automated chemiluminescence analyzer could detect 96 wells continuously. The results demonstrated that this method is ultra-sensitive, simple, and rapid for detecting cystatin C.

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The imaging of local glucose levels in tumor periphery via peroxyoxalate chemiluminescent nanoparticle–glucose oxidase–doped alginate hydrogel

Abstract: A simple, sensitive, and biological safety POCL–GOx–alginate/Ca gel system to detect and image local concentration of glucose in tumor periphery.

Cited by 16 publications

References 30 publications

Ultrasound-Enhanced Chemiluminescence for Bioimaging

Ultrasound-Enhanced Chemiluminescence for Bioimaging

All Eyes on Visible‐Light Peroxyoxalate Chemiluminescence Read‐Out Systems

Development of an Approach of High Sensitive Chemiluminescent Assay for Cystatin C Using a Nanoparticle Carrier

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