The immobilization of antineoplastic drug cyclophosphamide in calcium alginate

Grigor’ev, D. A.; Мusabekov, Kuanyshbek; Musabekov, Nurlan; Kusainova, Zh. Zh.

doi:10.1134/s0965545x17040022

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…To validate the delivery efficiency of 4M platform at different depths of the tumor tissue, we developed a 3D in vitro tumor model by embedding SiHa cells into the hydrogel that was crosslinked by sodium alginate and calcium chloride (Figure 2D; Figure S13, Supporting Information). [ 49,50 ] By 3D fluorescence scanning, we observed that the 4M platform achieved uniform, effective and safe electroporation within the artificial solid tumor (Figure 2E; Movie S2, Supporting Information). Further analysis was conducted through serial sections of the 3D model.…”

Section: Resultsmentioning

confidence: 99%

Multimicrochannel Microneedle Microporation Platform for Enhanced Intracellular Drug Delivery

Lin

Wang

Cai

et al. 2021

Adv Funct Materials

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Common delivery routes for chemotherapeutics are based on circulation, which faces clinical limitations to local delivery efficiency, and the conflict between the dose for anticancer effect and the systemic toxicity. The recent advances in localized delivery strategies aim to improve drug accumulation at the target site or directly transport into cells. However, most are not equipped to provide additional momentum in the process of cargo release, propagation, and intracellular movement, which limit their locomotion that relies on passive diffusion. In this work, a multimicrochannel microneedle microporation (4M) platform that achieves high efficiency, safety, and uniformity for in vivo intracellular delivery is proposed. By high precision 3D printing, internal microchannels are implemented through the microneedle, which offer a concentrated, safe electric field that not only accelerates the movement of cargo into deep tissue under electrophoresis, but also triggers cell electroporation, achieving enhanced transport across cell membrane. The platform proves efficient for the delivery of chemotherapeutics in solid tumors in vitro and in vivo, with significantly enhanced anticancer effect and reduced systemic toxicity. The platform serves as a general-purpose delivery tool to emerging drugs in vivo.

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Section: Resultsmentioning

confidence: 99%

Multimicrochannel Microneedle Microporation Platform for Enhanced Intracellular Drug Delivery

Lin

Wang

Cai

et al. 2021

Adv Funct Materials

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“…Sodium alginate (Alg–Na) produced from brown seaweed exhibits good gel‐forming properties in the presence of doubly charged cations (e.g., calcium ions) and is used as a component of various drug delivery systems. [ 12–14 ] A key property of these natural polyelectrolytes is the sensitivity of their functional groups to pH of medium. Alginate–chitosan (Alg–CH) complexes represent, therefore, promising polymer matrices for developing pharmaceutical products that may offer controlled and target release of drugs.…”

Section: Introductionmentioning

confidence: 99%

“…systems. [12][13][14] A key property of these natural polyelectrolytes is the sensitivity of their functional groups to pH of medium. Alginatechitosan (Alg-CH) complexes represent, therefore, promising polymer matrices for developing pharmaceutical products that may offer controlled and target release of drugs.…”

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confidence: 99%

Alginate/chitosan hydrogels as perspective transport systems for cefotaxime

et al. 2023

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This work reports synthesis of pH‐responsive alginate/chitosan hydrogel spheres with the average diameter of 2.0 ± 0.05 mm, which contain cefotaxime that is an antibiotic of the cefalosporine group. The spheres provided the cefotaxime encapsulation efficiency of 95 ± 1%. An in vitro release of cefotaxime from the spheres in the media that simulate human biological fluids in peroral delivery conditions was found to be a pH‐dependent process. The analysis of cefotaxime release kinetics by the Korsmeyer–Peppas model revealed a non‐Fickian mechanism of its diffusion, which may be related to intermolecular interactions occurring between the antibiotic and chitosan. Conductometry, UV spectroscopy, and IR spectroscopy were used to study complexation of chitosan with cefotaxime in aqueous media with varied pH, characterize the composition of the complexes, and calculate their stability constants. The composition of the cefotaxime–chitosan complexes was found to correspond to the 1.0:4.0 and 1.0:2.0 molar ratios of the components at pH 2.0 and 5.6, respectively. Quantum chemical modeling was used to evaluate energy characteristics of chitosan–cefotaxime complexation considering the influence of a solvent.

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