The immune effects of naturally occurring and synthetic nanoparticles

Chang, Christopher

doi:10.1016/j.jaut.2009.11.009

Cited by 156 publications

(99 citation statements)

References 108 publications

(95 reference statements)

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“…Since nanoparticles are foreign, their uptake may result in the release of the pro-inflammatory cytokines (Chang, 2010;Lee et al, 2009). The immunogenicity of synthetic polymers highly depended Toxicology and Applied Pharmacology xxx (2010) xxx-xxx on their size, shape, composition, surfactant properties, electrical charge and on the inherent ability of the host to recognise them.…”

Section: Introductionmentioning

confidence: 99%

In vivo uptake and acute immune response to orally administered chitosan and PEG coated PLGA nanoparticles

Semete

Booysen

Kalombo

et al. 2010

Toxicology and Applied Pharmacology

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a b s t r a c t a r t i c l e i n f oNanoparticulate drug delivery systems offer great promise in addressing challenges of drug toxicity, poor bioavailability and non-specificity for a number of drugs. Much progress has been reported for nano drug delivery systems for intravenous administration, however very little is known about the effects of orally administered nanoparticles. Furthermore, the development of nanoparticulate systems necessitates a thorough understanding of the biological response post exposure. This study aimed to elucidate the in vivo uptake of chitosan and polyethylene glycol (PEG) coated Poly, DL, lactic-co-glycolic Acid (PLGA) nanoparticles and the immunological response within 24 h of oral and peritoneal administration. These PLGA nanoparticles were administered orally and peritoneally to female Balb/C mice, they were taken up by macrophages of the peritoneum. When these particles were fluorescently labelled, intracellular localisation was observed. The expression of pro-inflammatory cytokines IL-2, IL-6, IL-12p70 and TNF-α in plasma and peritoneal lavage was found to remain at low concentration in PLGA nanoparticles treated mice as well as ZnO nanoparticles during the 24 hour period. However, these were significantly increased in lipopolysaccharide (LPS) treated mice. Of these pro-inflammatory cytokines, IL-6 and IL-12p70 were produced at the highest concentration in the positive control group. The anti-inflammatory cytokines IL-10 and chemokines INF-γ, IL-4, IL-5 remained at normal levels in PLGA treated mice. IL-10 and INF-γ were significantly increased in LPS treated mice. MCP-1 was found to be significantly produced in all groups in the first hours, except the saline treated mice. These results provide the first report to detail the induction of cytokine production by PLGA nanoparticles engineered for oral applications.

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Section: Introductionmentioning

confidence: 99%

In vivo uptake and acute immune response to orally administered chitosan and PEG coated PLGA nanoparticles

Semete

Booysen

Kalombo

et al. 2010

Toxicology and Applied Pharmacology

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“…Changes of immune responses (immunomodulation) not involving inflammation might also result [54][55][56][57][58]. It has been hypothesized that the latter changes might be linked to a higher risk of autoimmune, allergic and neoplastic disease [59]. In the case of high internal doses of Gd nanoparticles, skin thickening and fibrosis may occur in persons with severe renal dysfunction [18, and references therein].…”

Section: Determinants Of Human Inhalation Hazards Of Persistent Enginmentioning

confidence: 99%

Human health hazards of persistent inorganic and carbon nanoparticles

Reijnders

2012

J Mater Sci

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Persistent inorganic and carbon nanoparticles are increasingly engineered for applications and may also be present in conventional materials such as carbon black. Furthermore, they may originate from conventional non particulate materials by processes such as wear and tear. Persistent inorganic and carbon nanoparticles can be hazardous to humans. Relatively much research regards the hazards of inhaled nanoparticles. These may give rise to respiratory disease and to negative effects on other organs, including the cardiovascular system. Determinants of risk of inhaled nanoparticles include: number, size, surface characteristics, shape, structure, and the formation of assemblages. These determinants should preferentially be considered in exposure metrics. A major molecular mechanism underlying the inhalation hazard of nanoparticles is the generation of reactive oxygen species, but other mechanisms such as interactions with proteins and DNA may also contribute. Health hazards may also be linked to ingestion of persistent inorganic and carbon nanoparticles, dermal exposure and exposure of the eye. Standards for workplace exposure to persistent inorganic and carbon are currently emerging and there are options for hazard reduction by elimination and substitution of hazardous nanoparticles and by engineering controls.

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“…DNA-and carbon nano-tubes, fullerenes, nano-wires and nano-coatings, carbon black, synthetic agents contained in whiteners and additives supplemented to food for modification of texture. (Chang, 2010) With recent advances in nanotechnology, these designed and engineered nano-particles are being introduced in ever greater varieties, such as scratch-proof paints, lotus-effect stained glass, suntan lotion, toothpaste, etc. (Raab et al, 2010) Although their release into the environment is not intended in the first place, it will occur sooner rather than later -especially once wear and tear along with product degradation releases contained nano-particles into the environment where they easily can enter the food chain either via aerosolization or washing-out from dumping sites.…”

Section: Introductionmentioning

confidence: 99%

“…skin, gut and mainly the respiratory system. (Chang, 2010;Traidl-Hoffmann et al, 2009) Due to their small size, these particles possess completely different biological potentials when interacting with living organisms in comparison to particulate matter of increased dimensions. The unique properties are related to their enlarged surface-to-mass ratio in combination with their higher propensity for penetration of biological barriers, for deposition, e.g.…”

Section: Introductionmentioning

confidence: 99%

“…in the peripheral lung, and the increased overall retention in biological systems. (Chang, 2010;Alessandrini et al, 2006;Alessandrini et al, 2009) This is particularly true for nano-sized particles as the larger surface area per unit volume compared with their larger-sized siblings renders them biologically more active. (Geiser & Kreyling, 2010) Thus, within these dimensions, the well-known quote of Paracelsus "the dose makes the poison" , n e e d s t o b e r e v i s e d i n t h a t " the dose determines the mechanism".…”

Section: Introductionmentioning

confidence: 99%

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