The immune-related role of beta-2-microglobulin in melanoma

Wang, Chuqiao; Wang, Zeqi; Yao, Teng-Teng; Zhou, Jibo; Wang, Zhaoyang

doi:10.3389/fonc.2022.944722

Cited by 21 publications

(13 citation statements)

References 91 publications

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“…B16 melanoma cell line with endogenous expression of MHC-I (WT B16) and with loss of MHC-I through B2m gene deletion (B2m -/- B16) were utilized. Removal of MHC-I, a ligand for inhibitory Ly49 receptors on mouse NK cells, is an established approach to induce NK cell activation ( 24 ). However, loss of MHC-I did not significantly alter number or size of metastatic foci in the lungs, which may be because B16 cells endogenously express very low levels of MHC-I ( Figures 1A–C , Figure S1 ) ( 25 ).…”

Section: Resultsmentioning

confidence: 99%

Natural killer cells suppress cancer metastasis by eliminating circulating cancer cells

et al. 2023

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Despite significant advances in cancer treatment, the metastatic spread of malignant cells to distant organs remains a major cause of cancer-related deaths. Natural killer (NK) cells play a crucial role in controlling tumor metastasis; however, the dynamics of NK cell-mediated clearance of metastatic tumors are not entirely understood. Herein, we demonstrate the cooperative role of NK and T cells in the surveillance of melanoma metastasis. We found that NK cells effectively limited the pulmonary seeding of B16 melanoma cells, while T cells played a primary role in restricting metastatic foci growth in the lungs. Although the metastatic foci in the lungs at the endpoint were largely devoid of NK cells, they played a prominent role in promoting T cell recruitment into the metastatic foci. Our data suggested that the most productive interaction between NK cells and metastatic cancer cells occurred when cancer cells were in circulation. Modifying the route of administration so that intravenously injected melanoma cells bypass the first liver passage resulted in significantly more melanoma metastasis to the lung. This finding indicated the liver as a prominent site where NK cells cleared melanoma cells to regulate their seeding in the lungs. Consistent with this notion, the liver and the lungs of the tumor-bearing mice showed dominance of NK and T cell activation, respectively. Thus, NK cells and T cells control pulmonary metastasis of melanoma cells by distinct mechanisms where NK cells play a critical function in shaping T cell-mediated in situ control of lung-seeded cancer cells. A precise understanding of the cooperative role of NK and T cells in controlling tumor metastasis will enable the development of the next generation of cancer immunotherapies.

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Section: Resultsmentioning

confidence: 99%

Natural killer cells suppress cancer metastasis by eliminating circulating cancer cells

et al. 2023

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“…Melanoma is widely recognized as one of the most immunogenic human cancer types and a strong correlation between the infiltration of T cells, both in primary lesions and in melanoma metastases, and clinical outcome has been described 51 – 53 . We, therefore, perform scSpace to reconstruct the pseudo-space of cells in melanoma scRNA-seq data generated by Tirosh et al 31 and further identify the spatial heterogeneity of 2064T cells.…”

Section: Resultsmentioning

confidence: 99%

Reconstruction of the cell pseudo-space from single-cell RNA sequencing data with scSpace

et al. 2023

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Tissues are highly complicated with spatial heterogeneity in gene expression. However, the cutting-edge single-cell RNA-seq technology eliminates the spatial information of individual cells, which contributes to the characterization of cell identities. Herein, we propose single-cell spatial position associated co-embeddings (scSpace), an integrative method to identify spatially variable cell subpopulations by reconstructing cells onto a pseudo-space with spatial transcriptome references (Visium, STARmap, Slide-seq, etc.). We benchmark scSpace with both simulated and biological datasets, and demonstrate that scSpace can accurately and robustly identify spatially variated cell subpopulations. When employed to reconstruct the spatial architectures of complex tissue such as the brain cortex, the small intestinal villus, the liver lobule, the kidney, the embryonic heart, and others, scSpace shows promising performance on revealing the pairwise cellular spatial association within single-cell data. The application of scSpace in melanoma and COVID-19 exhibits a broad prospect in the discovery of spatial therapeutic markers.

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“…B2MG excretion increases when the renal tubules are damaged, so B2MG may be a promising biomarker for AKI. 63,64 The urinary levels of B2MG showed good accuracy in diagnosing AKI in pediatric emergency centers. 65 In fact, B2MG is valuable for early diagnosis of nAKI.…”

Section: Glutathione S-transferasementioning

confidence: 99%

“…B2MG passes freely through the glomerulus and is completely reabsorbed by the proximal renal tubules. B2M excretion increases when the renal tubules are damaged, so B2MG may be a promising biomarker for AKI 64,65 . The urinary levels of B2MG showed good accuracy in diagnosing AKI in pediatric emergency centers 66 .…”

Section: B2mgmentioning

confidence: 99%

Gut Microbiota and Neonatal Acute Kidney Injury

Yang,

He,

Dong

2024

Am J Perinatol

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Neonatal acute kidney injury has a complex pathogenesis and the gut microbiota is receiving increasing attention. Gut-kidney axis establishes a bidirectional link between gut microbiota and acute kidney injury. Promoting the study of gut microbiota and neonatal acute kidney injury will contribute to early detection and treatment of this disease. A series of promising biomarkers have emerged in recent years to predict neonatal acute kidney injury earlier than serum creatinine and urine output. However, comprehensive reports on these biomarkers are relatively scarce. In addition, the gut microbiota and biomarkers associated with neonatal acute kidney injury deserve further exploration. Herein, this review summarizes the relationship between gut microbiota and neonatal acute kidney injury biomarkers to deepen our understanding of the role of the gut-kidney axis in neonatal acute kidney injury and provide potential treatment options for neonatal acute kidney injury.

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The immune-related role of beta-2-microglobulin in melanoma

Cited by 21 publications

References 91 publications

Natural killer cells suppress cancer metastasis by eliminating circulating cancer cells

Natural killer cells suppress cancer metastasis by eliminating circulating cancer cells

Reconstruction of the cell pseudo-space from single-cell RNA sequencing data with scSpace

Gut Microbiota and Neonatal Acute Kidney Injury

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