The immunological effects of oil sands surface waters and naphthenic acids on rainbow trout (Oncorhynchus mykiss)

Leclair, Liane A.; MacDonald, Gillian Z.; Phalen, Laura J.; Köllner, Bernd; Hogan, Natacha S.; Heuvel, Michael R. van den

doi:10.1016/j.aquatox.2013.08.009

Cited by 46 publications

(24 citation statements)

References 30 publications

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“…Arkoosh et al 2001;Hutchinson et al 2003;Hoeger et al 2004;Salo et al 2007;Leaver et al 2010;Connon et al 2012;Gagne et al 2013), or some studies exposed fish in the laboratory to complex environmental matrices such as crude oil or oil sands and studied the effects on their immune parameters (Tahir & Secombes 1995;Nakayama et al 2008;Song et al 2011Song et al , 2012Bado-Nilles et al 2011;Leclair et al 2013). Among the pioneering studies on environmental impacts on the fish immune system were those of Arkoosh et al (e.g.…”

Section: Field Studies (8%)mentioning

confidence: 97%

“…Ex vivo assays were taken as in vivo study for this analysis, because in this approach, the cells are conditioned in vivo and only their response capacity is measured outside the animal (Gatta et al 2001;Dautremepuits et al 2004;Leclair et al 2013). The in vitro studies included experiments with permanent cell lines or with cells isolated from non-exposed control animals (Bols et al 2001;Law et al 2001;Castro et al 2011).…”

Section: 35mentioning

confidence: 99%

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20 Years of fish immunotoxicology – what we know and where we are

Rehberger

Werner

Hitzfeld

et al. 2017

Critical Reviews in Toxicology

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Despite frequent field observations of impaired immune response and increased disease incidence in contaminant-exposed wildlife populations, immunotoxic effects are rarely considered in ecotoxicological risk assessment. The aim of this study was to review the literature on immunotoxic effects of chemicals in fish to quantitatively evaluate (i) which experimental approaches were used to assess immunotoxic effects, (ii) whether immune markers exist to screen for potential immunotoxic activities of chemicals, and (iii) how predictive those parameters are for adverse alterations of fish immunocompetence and disease resistance. A total of 241 publications on fish immunotoxicity were quantitatively analyzed. The main conclusions included: (i) To date, fish immunotoxicology focused mainly on innate immune responses and immunosuppressive effects. (ii) In numerous studies, the experimental conditions are poorly documented, as for instance age or sex of the fish or the rationale for the selected exposure conditions is often missing. (iii) Although a broad variety of parameters were used to assess immunotoxicity, the rationale for the choice of measured parameters was often not given, remaining unclear how they link to the suspected immunotoxic mode of action of the chemicals. (iv) At the current state of knowledge, it is impossible to identify a set of immune parameters that could reliably screen for immunotoxic potentials of chemicals. (v) Similarly, in fish immunotoxicology there is insufficient understanding of how and when chemical-induced modulations of molecular/cellular immune changes relate to adverse alterations of fish immunocompetence, although this would be crucial to include immunotoxicity in ecotoxicological risk assessment.

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Section: Field Studies (8%)mentioning

confidence: 97%

Section: 35mentioning

confidence: 99%

20 Years of fish immunotoxicology – what we know and where we are

Rehberger

Werner

Hitzfeld

et al. 2017

Critical Reviews in Toxicology

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“…Fluorescent bile metabolites were analyzed according to methods described in Leclair et al [21]. This technique involved HPLC-fluorescence analysis of diluted bile at phenanthrene (excitation 256 nm and emission 380 nm) and benzo[a]pyrene (excitation 380 nm and emission 430 nm) wavelengths.…”

Section: Tissue Analysesmentioning

confidence: 99%

Population impacts in white sucker (Catostomus commersonii) exposed to oil sands–derived contaminants in the Athabasca River

Arens

Hogan

et al. 2017

Enviro Toxic and Chemistry

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Biological and chemical endpoints were measured in white sucker collected downstream of Athabasca oil sands developments (AB, Canada) and compared with those at Calling Lake (AB, Canada), a reference location upstream of the Athabasca oil sands deposit. Naphthenic acid concentrations were also measured at 14 sites in the Athabasca River watershed. Concentrations of naphthenic acids were elevated in tributaries adjacent to oil sands mining developments. Tributary naphthenic acid profiles were more similar to aged oil sands process water than samples from the Athabasca River, suggesting an influence of tailings in the tributaries. White sucker showed higher energy storage in the Athabasca River as indicated by significantly higher condition and liver size. White sucker were not investing that energy into reproductive effort as measured by gonad size and fecundity, which were significantly reduced relative to the reference location. White sucker showed increased exposure to polycyclic aromatic hydrocarbons as indicated by hepatic cytochrome P4501A (CYP1A) activity and fluorescent bile metabolites, as well as higher concentrations of naphthenic acids in bile. Cadmium, copper, nickel, and selenium were also elevated in white sucker liver tissue compared with the reference location. Based on the exposure profile and response pattern observed, effects on energy storage and utilization in white sucker from the Athabasca River most likely resulted from exposure to polycyclic aromatic hydrocarbons derived from petrogenic and pyrolytic sources. Environ Toxicol Chem 2017;36:2058-2067. © 2017 SETAC.

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“…Similarly, immunotoxic effects, including decreased circulating leukocytes and decreased antibody response to a bacterial pathogen, have been described in fish (Rainbow trout Oncorhynchus mykiss) exposed in situ to oil sands processed waters (OSPW) and experimentally to NAs (Leclair et al, 2013;McNeill et al, 2012).…”

Section: Introductionmentioning

confidence: 97%