Stress response, biotransformation effort, and immunotoxicity in captive birds exposed to inhaled benzene, toluene, nitrogen dioxide, and sulfur dioxide

Cruz-Martinez, Luis; Smits, Judit E. G.; Fernie, Kim J.

doi:10.1016/j.ecoenv.2014.10.016

Cited by 25 publications

(21 citation statements)

References 55 publications

(64 reference statements)

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“…Hepatic ethoxyresorufin O ‐deethylase activity was assessed in liver aliquots following the method described by Cruz‐Martinez et al . All chemicals and materials were purchased from Sigma‐Aldrich and from VWR International (Edmonton, AB, Canada) unless otherwise noted.…”

Section: Methodsmentioning

confidence: 99%

Sublethal health effects in laboratory rodents from environmentally relevant exposures to oil sands contaminants

Rodríguez-Estival

North

Smits

2015

Enviro Toxic and Chemistry

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Increasing activity of oil sands extraction and processing in northern Alberta is marked by ongoing controversy about the nature and extent of associated environmental impacts. Bitumen contains a mixture of toxic chemicals, including metals and residual polycyclic aromatic hydrocarbons (PAHs), whose release into the environment poses a distinct risk to the surrounding environment, plus wildlife and human health. In the present study, the authors evaluated several subclinical biomarkers of exposure and effect to mixtures of metals (Pb, Cd, and Hg) and/or PAHs (3 alkylated forms) at environmentally relevant concentrations (100-fold and 10-fold higher than the maximum dissolved concentrations found in snow, to simulate a worst-case scenario), using laboratory mice as a model for future studies of small mammals in the wild. Both metals and alkyl-PAHs exposure were associated with 1) increased relative liver, kidney, and spleen size; 2) alterations in the homeostasis of the antioxidant vitamins A and E in liver; and 3) compromised glutathione redox status in testes, with results also indicating synergistic interactions from co-exposure. The combination of morphometric and oxidative stress biomarkers provide reliable and sensitive measures of the response to contaminant exposure in a mammalian model, suggesting associated physiological costs. Based on the present experimental study, the authors propose that wild small mammals will prove to be valuable sentinel species reflecting sublethal health effects from oil sands-related contaminants. The present study's results also present a basis for the interpretation of future field data.

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Section: Methodsmentioning

confidence: 99%

Sublethal health effects in laboratory rodents from environmentally relevant exposures to oil sands contaminants

Rodríguez-Estival

North

Smits

2015

Enviro Toxic and Chemistry

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“…For example, Pattee et al (1981) investigated experimental leadshot poisoning in five bald eagles (Haliaeetus leucocephalus) from a wildlife rescue center that were unsuitable for release or captive breeding, and were thus available for research purposes. However, the species most often used so far in dietary exposure studies has been the American kestrel, both for acute toxicity (Rattner et al, 2011), reproductive toxicity (Lincer, 1975;Fernie et al, 2009Fernie et al, , 2011Sullivan et al, 2013), immunotoxicity (Fernie et al, 2005;Cruz-Martinez et al, 2015b), and endocrine disruption research (Love et al, 2003). In addition, exposure experiments with emerging contaminants have recently highlighted endocrine disrupting properties in American kestrels (Marteinson et al, 2011a,b).…”

Section: Birds Of Preymentioning

confidence: 97%

Selecting the right bird model in experimental studies on endocrine disrupting chemicals

Jaspers

2015

Front. Environ. Sci.

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Birds have been used as model species in ecotoxicological research for decades but have only recently been included in toxicity testing schemes. However, the avian fauna is very diverse. Given this diversity, the ecology, behavior, and reproduction should be considered when selecting the appropriate bird model in ecotoxicological studies. This article focusses on choosing the right bird model species for experimental studies with endocrine disrupting chemicals (EDCs). EDCs have been associated with adverse effects on reproduction and development in birds and other wildlife. In addition, new EDCs continue to emerge and the concern for potential effects in humans and wildlife is calling for increased toxicity testing and hence appropriate model species. Common bird model species used in ecotoxicological studies investigating EDCs will be reviewed. In addition, considerations for selecting the right bird model, along with potential drawbacks and restrictions on the use of certain species will be discussed.

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“…Moreover, a number of studies have referred to an inhalation exposure (73,74), while only in a few cases, exposure by ingestion (75,76) or dermal contact (77,78) has been reported. The progressive reduction of the levels of exposure both in environmental and occupational settings have led researchers to focus their attention on the health effects observed with low doses of benzene, particularly those related to cancer.…”

Section: Benzenementioning

confidence: 99%

Occupational exposure to carcinogens: Benzene, pesticides and fibers

Falzone

Marconi

Loreto

et al. 2016

Molecular Medicine Reports

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It is well known that the occupational exposure to contaminants and carcinogens leads to the development of cancer in exposed workers. In the 18th century, Percivall Pott was the first to hypothesize that chronic exposure to dust in the London chimney sweeps was associated with an increased risk of developing cancer. Subsequently a growing body of evidence indicated that other physical factors were also responsible for oncogenic mutations. Over the past decades, many carcinogens have been found in the occupational environment and their presence is often associated with an increased incidence of cancer. Occupational exposure involves several factors and the association between carcinogens, occupational exposure and cancer is still unclear. Only a fraction of factors is recognized as occupational carcinogens and for each factor, there is an increased risk of cancer development associated with a specific work activity. According to the International Agency for Research on Cancer (IARC), the majority of carcinogens are classified as ‘probable’ and ‘possible’ human carcinogens, while, direct evidence of carcinogenicity is provided in epidemiological and experimental studies. In the present review, exposures to benzene, pesticides and mineral fibers are discussed as the most important cancer risk factors during work activities.

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Stress response, biotransformation effort, and immunotoxicity in captive birds exposed to inhaled benzene, toluene, nitrogen dioxide, and sulfur dioxide

Cited by 25 publications

References 55 publications

Sublethal health effects in laboratory rodents from environmentally relevant exposures to oil sands contaminants

Sublethal health effects in laboratory rodents from environmentally relevant exposures to oil sands contaminants

Selecting the right bird model in experimental studies on endocrine disrupting chemicals

Occupational exposure to carcinogens: Benzene, pesticides and fibers

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