The immunology of animal papillomaviruses

Nicholls, P.K.; Stanley, Margaret

doi:10.1016/s0165-2427(99)00165-8

Cited by 75 publications

(75 citation statements)

References 123 publications

(40 reference statements)

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“…The importance of this study was to characterize the PVs types present in dogs of Brazil, since immunity is typespecific, and CPV1 L1 virus like-particles vaccines can protect dogs against the development of mucosal papillomas (Suzich et al 1995, Stanley et al 2001, while the immu- nity can be passively transferred to offsprings (Nicholls & Stanley 2000). Additionally, considering the great diversity of canine PVs, the efficiency of degenerate primers, as demonstrated during this investigation, facilitate the identification of putative new PV types (Zaugg et al 2005, Lange et al 2013.…”

Section: Discussionmentioning

confidence: 91%

Identification of canine papillomavirus type 1 (CPV1) DNA in dogs with cutaneous papillomatosis

et al. 2014

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Canine oral papillomavirus (COPV), also known as Canine Papillomavirus type 1 (CPV1), induces papillomas at the mucous membranes of the oral cavity and at the haired skin of dogs. The classification of Papillomavirus (PV) types is based on the L1 capsid protein and nucleotide sequence; so far, 14 CPV types have been described in several countries, but the molecular characterization of CPV in Brazil is lacking. This study investigated the presence of the PV in seven papillomas from four mixed breed dogs from Londrina/PR, Southern Brazil, by partial sequencing of the L1 gene. Seven exophytic cutaneous lesions were surgically removed and processed for histopathological and molecular characterization. Histopathology confirmed the lesions as viral papillomas due to typical histological features. Polymerase Chain Reaction (PCR) assay using the FAP59 and FAP64 primers targeted the L1 gene followed by sequence analysis of the amplicons identified CPV1 in all evaluated papilloma samples. This study represents the first description of CPV1 DNA associated with canine papillomatosis in Brazil.

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Section: Discussionmentioning

confidence: 91%

Identification of canine papillomavirus type 1 (CPV1) DNA in dogs with cutaneous papillomatosis

et al. 2014

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“…Acomete predominantemente cães jovens ou adultos imunossuprimidos STANLEY, 1999). A maior susceptibilidade de cães jovens à infecção sugere que cães adultos adquiram imunidade devido ao contato prévio com o vírus STANLEY, 2000). A maioria das infecções regride espontaneamente entre quatro a oito semana pós-infecção.…”

Section: Revisão De Literaturaunclassified

“…Nos quadros clínicos complicados, como ulceração dos tumores e obstrução faringeal, ou por motivos estéticos, estão disponíveis vários protocolos terapêuticos, que incluem ressecção cirúrgica, fármacos anti-virais, vacinas autócnes ou fármacos imunomoduladores (TIZARD, 2000;STANLEY, 2000).…”

Section: Revisão De Literaturaunclassified

Papilomatose oral em cães: revisão da literatura e estudo de doze casos

Fernandes

Ribeiro

Fedato³

et al. 2009

Sem. Ci. Agr.

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ResumoPapilomatose canina é uma enfermidade infecto-contagiosa viral caracterizada pela formação de papilomas orais, cutâneos ou oculares, geralmente benignos. O tratamento é indicado quando ocorre persistência dos tumores, lesões múltiplas causando obstrução faringeana, disfagia ou por razões estéticas. Diferentes protocolos de tratamento são descritos incluindo excisão cirúrgica, criocirurgia, eletrocirurgia, vacinas autógenas ou recombinantes, drogas imunomoduladoras, quimioterapia sistêmica ou intralesional. Foram revisados os principais aspectos clínico-epidemiológicos da papilomatose oral canina. Nos 12 animais estudados foram observados papilomas predominantemente em região de língua, gengiva e palato, com até 12 meses de idade e infecção combinada com erliquiose. O tratamento com Propionibacterium acnes e/ou vacina autócne surtiu efeito em oito animais (66,7%). Palavras-chave: Cão, papilomatose, Papillomavirus, clínica, epidemiologia, terapia AbstractCanine papillomatosis is an infectious viral disease characterized by oral, cutaneous or ocular papillomas, usually benign. The treatment is indicated in animals, with multiple tumors that produce pharyngeal obstruction, and problems of eating or for aesthetic reasons. Different treatment protocols have been proposed, including surgical excision, cryosurgery, electro surgery, autogenous or recombinant vaccines, imunomodulators drugs, systemic and intralesional chemotherapy. In this study were reviewed the more important aspects of canine oral papillomatosis. In the 12 studied animals, the papillomas were observed predominantly in mouth, gum and palate regions, in puppies until 12 months, presenting combined infection with ehrlichiosis. The treatment using Propionibacterium acnes and/or autogenous vaccine showed efficacy in eight dogs (66.7%).

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“…Além da identificação dos tipos virais já descritos, essas estratégias têm ainda proporcionado a identificação de supostos novos tipos virais em várias espécies animais e em humanos (Forslund et al 1999, Antonsson & Hansson 2002, Ogawa et al 2004. A epidemiologia molecular das infecções pelos PV possui importância na profilaxia das infecções, uma vez que a imunidade é tipo-específica (Nicholls & Stanley, 2000). Em humanos já foram descritos mais de 200 tipos do HPV, demonstrando a diversidade dessa família viral (Bernard 2005).…”

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Análise filogenética de papilomavírus bovino associado com lesões cutâneas em rebanhos do Estado do Paraná

et al. 2007

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analysis analysis analysis analysis analysis of bovine papillomavirus associated with skin warts in cattle herds from the of bovine papillomavirus associated with skin warts in cattle herds from the of bovine papillomavirus associated with skin warts in cattle herds from the of bovine papillomavirus associated with skin warts in cattle herds from the of bovine papillomavirus associated with skin warts in cattle herds from the state of Bovine papillomavirus (BPV) infection causes hyperplastic lesions in the cutaneous epithelium of cattle. Six types of BPV were classified in two sub-groups, being correlated to the anatomical regions of the infection and morphologic characteristics of the lesions. The present study was carried out to identify the types of BPV present in skin warts of cattle from the state of Paraná, Brazil. The generic primers FAP59 and FAP64 were used for amplification of a 478 bp fragment of BPV L1 gene in nine cutaneous papilloma samples obtained from six animals in four herds. In all papillomas examined, a product with the expected molecular size was amplified. Phylogenetic analysis of the PCR products identified BPV-2 in three samples, BPV-1 in one, and BPV-6 in five papillomas. BPV-6 was detected in cutaneous papillomas of the teat and in other body parts as well. In one animal, from which more than one sample was collected, a concomitant infection by BPV-1 and BPV-2 was identified. The five positive BPV-6 samples showed a nucleotide identity of 100% with the sequence of the reference strain available in GenBank. However, differences among BPV-2 and BPV-1 Brazilian samples and the respective reference sequences deposited in GenBank were observed. Molecular comparison of the two BPV-2 strains identified showed the involvement of two viral variants. This study revealed the diversity of BPV types circulating in the state of Paraná.INDEX TERMS: Bovine papillomavirus, cutaneous papillomatosis, phylogeny, polymerase chain reaction.Pesq. Vet. Bras. 27(7): 314-318, julho 2007 Análise filogenética do papilomavírus bovino associado a lesões cutâneas em rebanhos do Estado do Paraná 315

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The immunology of animal papillomaviruses

Cited by 75 publications

References 123 publications

Identification of canine papillomavirus type 1 (CPV1) DNA in dogs with cutaneous papillomatosis

Identification of canine papillomavirus type 1 (CPV1) DNA in dogs with cutaneous papillomatosis

Papilomatose oral em cães: revisão da literatura e estudo de doze casos

Análise filogenética de papilomavírus bovino associado com lesões cutâneas em rebanhos do Estado do Paraná

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