The immunology of the fetal–placental unit comes of age

Lorenzo, Rebecca De; Canti, Valentina; Manfredi, Angelo A.; Rovere‐Querini, Patrizia

doi:10.1111/cei.13359

Cited by 2 publications

(2 citation statements)

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“…It is likely the microbiomes of the female reproductive system, other compartments of the human body (gut, oral cavity) and developing infant microbiomes interconnect and interact in health and disease 43 . A perfect balance between the maternal immune system, foetus and micro‐organisms is a prerequisite for a healthy pregnancy, and any deviation to this gentle equilibrium can manifest in complications of pregnancy 44 . Being a soluble pattern recognition molecule, MBL also facilitates removal of damaged and dying cells via efferocytosis.…”

Section: Discussionmentioning

confidence: 99%

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Serum mannose–binding lectin (MBL) concentrations are reduced in non‐pregnant women with previous adverse pregnancy outcomes

et al. 2020

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Mannose‐binding lectin (MBL) is an important component of the innate immunity, and it is responsible not only for opsonization of micro‐organisms, but also for efferocytosis. The aim of this study was to investigate whether MBL concentrations and lectin complement pathway activity are altered in non‐pregnant women with previous adverse pregnancy outcomes. Patients were divided into four groups on the basis of their history of pregnancy complications, including control patients who had uncomplicated pregnancies and term deliveries (control, n = 33), and three groups of patients with a history of pregnancy complications, including preterm labour (n = 29), recurrent miscarriage (n = 19) or unexplained intrauterine foetal death (IUFD; n = 17). All women enrolled in the study had an interval of three to six months following their previous pregnancy, and they agreed to have a blood sample taken. We found significantly higher MBL concentrations and functional activity of the lectin complement pathway in healthy controls who had previous uneventful term pregnancies (1341 ng/mL; activity 100% (IQR: 62%‐100%)), compared to women with the history of IUFD (684 ng/mL, P = .008; activity 8.5% (IQR: 0%‐97.8%), P = .011), recurrent miscarriage (524 ng/mL, P = .022; activity 44% (IQR: 4%‐83%), P = .011) or preterm labour (799 ng/mL, P = .022; activity 62.5% (IQR: 0%‐83%), P = .003). Our results suggest that inadequate function of the complement lectin pathway is associated with a higher risk of preterm labour, recurrent miscarriage and unexplained intrauterine foetal death.

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Section: Discussionmentioning

confidence: 99%

“…43 A perfect balance between the maternal immune system, foetus and micro-organisms is a prerequisite for a healthy pregnancy, and any deviation to this gentle equilibrium can manifest in complications of pregnancy. 44 Being a soluble pattern recognition molecule, MBL also facilitates removal of damaged and dying cells via efferocytosis.…”

Section: Discussionmentioning

confidence: 99%