The immunomodulatory effect of intradermal allogeneic PBMC therapy in patients with recurrent spontaneous abortion

Sarkesh, Aila; Sorkhabi, Amin Daei; Parhizkar, Forough; Soltani-Zangbar, Mohammad Sadegh; Yousefi, Mehdi; Aghebati‐Maleki, Leili

doi:10.1016/j.jri.2023.103818

Cited by 7 publications

(2 citation statements)

References 38 publications

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“…The search for new laboratory assays that can be useful in the management of RM is a major challenge for researchers in pregnancy loss. In this scenario, adipokines, miRNAs, and lipids released by obese adipose tissue emerge as potential diagnostic biomarkers 134,135 …”

Section: Future Perspectivesmentioning

confidence: 99%

“…In this scenario, adipokines, miR-NAs, and lipids released by obese adipose tissue emerge as potential diagnostic biomarkers. 134,135 The search for new immunotherapies for RM is another current Furthermore, the teratogenicity and safety of these medications need to be assessed during the periconceptional period until pregnancy, as well as their impact on offspring.…”

Section: Future Perspectivesmentioning

confidence: 99%

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Obesity and recurrent miscarriage: The interconnections between adipose tissue and the immune system

Gonçalves,

Feitosa,

Cavalcante

et al. 2023

American J Rep Immunol

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Currently, obesity is considered a global public health problem. It is the main risk factor for noncommunicable diseases and reproductive complications, such as recurrent miscarriage (RM). RM affects approximately 1% of couples of reproductive age, and recent studies suggest that its prevalence is increasing. Immunological abnormalities may be responsible for a significant number of cases of unexplained RM. Obesity is recognized as a chronic low‐grade inflammatory condition. The accumulation of fat in obese adipose tissue promotes changes in the local and systemic immune response. Adipokines, exosomes, micro‐RNAs, lipids, and other factors released or secreted by adipose tissue are responsible for the interconnection between obesity and the immune system. Obesity‐induced dysregulation of the innate and acquired immune response is also involved in the immunopathology of pregnancy loss in patients with unexplained RM. Therefore, understanding the communication pathways between maternal adipose tissue and the immune response in women living with obesity and RM is an important objective. Thus, diagnostic tools and new immunomodulatory therapies may be proposed for the management of patients with concurrent obesity and RM.

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Section: Future Perspectivesmentioning

confidence: 99%

Section: Future Perspectivesmentioning

confidence: 99%