The Immunomodulatory Effects of Plant Extracts and Plant Secondary Metabolites on Chronic Neuroinflammation and Cognitive Aging: A Mechanistic and Empirical Review

Kure, Christina; Timmer, Jorinde; Stough, Con

doi:10.3389/fphar.2017.00117

Cited by 38 publications

(21 citation statements)

References 151 publications

(197 reference statements)

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“…NF-κB seems to be the culprit of inflammation during aging, since this signaling system integrates the intracellular regulation of immune responses in both aging and age-related diseases (Salminen et al 2008;Tegenge et al 2014;Yang et al 2014). Further, it has been demonstrated that curcumin blocks the production of pro-inflammatory and cytotoxic mediators such as TNF-alpha, IL-1 alpha, and IL-6 (Jin et al 2007;Kure et al 2017;Lee et al 2007). Taken together, these actions by curcumin may be the underlying cause of improved performance on the DRST task by monkeys in this study receiving long-term administration of curcumin.…”

Section: Summary Of Resultsmentioning

confidence: 99%

Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys

et al. 2017

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Studies of both humans and non-human primates have demonstrated that aging is typically characterized by a decline in cognition that can occur as early as the fifth decade of life. Age-related changes in working memory are particularly evident and mediated, in part, by the prefrontal cortex, an area known to evidence age-related changes in myelin that is attributed to inflammation. In recent years, several nutraceuticals, including curcumin, by virtue of their anti-inflammatory and antioxidant effects, have received considerable attention as potential treatments for age-related cognitive decline and inflammation. Accordingly, we assessed for the first time in a non-human primate model of normal aging the efficacy of dietary intervention using the natural phenol curcumin to ameliorate the effects of aging on spatial working and recognition memory. Results revealed that monkeys receiving daily administration of curcumin over 14-18 months demonstrated a greater improvement in performance on repeated administration of a task of spatial working memory compared to monkeys that received a control substance.

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Section: Summary Of Resultsmentioning

confidence: 99%

Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys

et al. 2017

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“…One of the biological contributors to neurodegeneration and cognitive aging is chronic neuroinflammation. Accordingly, plant extracts with anti‐inflammatory properties have been extensively studied in relation to their potential use in treating cognitive decline (da Costa, Cavalcanti, de Queiroz, & de Azevedo, ; Kure, Timmer, & Stough, ; Meeusen & Decroix, ; Shal, Ding, Ali, Kim, & Khan, ; Wang et al, ). Bhattacharya and Bhattacharya () reported that 14‐day administration of devil's claw extract (100 and 200 mg/kg) stimulated, in a dose‐dependent manner, rat cortex superoxide dismutase, catalase, and glutathione peroxidase activities, with a concomitant reduction of tissue lipid peroxidation.…”

Section: Experimental Studiesmentioning

confidence: 99%

Devil's claw (Harpagophytum procumbens) and chronic inflammatory diseases: A concise overview on preclinical and clinical data

Menghini

Recinella

Leone

et al. 2019

Phytotherapy Research

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Devil's claw (Harpagophytum procumbens) is an herbaceous plant, which can be found in the arid steppes of South Africa, particularly in the Kalahari Desert. As traditional medicine, devil's claw has been long used in the forms of infusions, decoctions, tinctures, powders, and extracts. The main compounds of devil's claw are iridoid glycosides, such as harpagoside, harpagide, and procumbide, which are present in the plant tubers. Additionally, chemical constituents such as sugars (mainly the tetrasaccharide stachyose), triterpenoids (oleanolic and ursolic acid), phytosterols (primarily β‐sitosterol), aromatic acids (caffeic, cinnamic, and chlorogenic acids), and flavonoids (luteolin and kaempferol) can be found in the plant. In order to investigate the applicative potential of devil's claw as therapeutic agent, we performed a review by focusing on its potential role in managing inflammation‐ and oxidative stress‐related diseases, including arthritis, osteoporosis, inflammatory bowel disease, low‐back pain, diabetes, and neurodegeneration.

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“…Bacopa monnieri [20] 500 mg/day Powder of Bacopa monnieri extract filled in a capsule at 08.00 Hrs with one cup of warm water after breakfast Tinospora cordifolia [21] 500 mg/day Powder of Tinospora cordifolia extract filled in a capsule at 11.00 Hrs with one cup of warm water…”

Section: Phytomedicine Scientific Names Quantity Given Mode and Timementioning

confidence: 99%

Treatment and Control of Covid-19 (Corona Virus Disease 2019) By Non-invasive (h.i.p) Non-drug Therapy in Combination Anti-influenza an (Oseltamivir (rx) Tamiflue) Drug-Novel Case Report

Ather¹,

Costigliola²

2020

SSR-IIJLS

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Background:Covid-19 is a new born sibling of the influenza family of SARS-CoV-2, named on February 11, as a new type of corona virus by the WHO. Covid-19 indicates its close relationship with activity and approaches with the SARS virus, which further triggered as epidemic in 2003 and 2004 and now similar lung triggered by SARS-CoV-2 is called Covid-19 (Corona Virus Disease 2019). Methods: A combination of integrative therapies were administered to a 27 year old female positive with unknown SARS-CoV identified as COVID-19 with a query of coronavirus contaminated from travel history and a student of Wuhan with a respiratory congestion, integrative approach of non-invasive (ion therapy) and non-drug therapy, quantitative analysis by real time PCR, vital signs were recorded beforeand after the treatment, as all the vitals were normal and real time PCR results were monitored. Results: The integrative therapy with isolation for 29 days from 31 st January to 27 th February was found to be satisfactory and the report, which has Real time PCR values detecting Covid-19 positive on 29 th January 2020 gave a negative result,it showed not detected and less than 35 Ct for the test. Conclusion: The integrative approach showed that it has high potential in treatment of Covid-19and can further imbibed in republic of china as well as other places where in 136 volunteers are part of the study and this could be an adjuvant therapy with a integrative approach for Covid-19 treatments.

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The Immunomodulatory Effects of Plant Extracts and Plant Secondary Metabolites on Chronic Neuroinflammation and Cognitive Aging: A Mechanistic and Empirical Review

Cited by 38 publications

References 151 publications

Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys

Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys

Devil's claw (Harpagophytum procumbens) and chronic inflammatory diseases: A concise overview on preclinical and clinical data

Treatment and Control of Covid-19 (Corona Virus Disease 2019) By Non-invasive (h.i.p) Non-drug Therapy in Combination Anti-influenza an (Oseltamivir (rx) Tamiflue) Drug-Novel Case Report

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