The Impact of a Corticotectal Impulse on the Awake Superior Colliculus

Bereshpolova, Yulia; Stoelzel, Carl R.; Gusev, Alexander G.; Bezdudnaya, Tatiana; Swadlow, Harvey A.

doi:10.1523/jneurosci.4402-05.2006

Cited by 32 publications

(21 citation statements)

References 68 publications

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“…Perhaps most consistently, we observed a characteristic CSD depth profile, with current sources and sinks, or net inward and outward transmembrane currents, reflecting the approximate location of the anatomical border between the two main superficial SC layers, the SGS and SO. A previous report in awake rabbits reported the location of the ID more superficially in the upper SGS (Bereshpolova et al 2006). However, the relative size of various SC layers, and the SGS in particular, is known to differ between species (Hilbig et al 2000).…”

Section: Visual Responses Display Laminar Specificitymentioning

confidence: 91%

Laminar profile of visual response properties in ferret superior colliculus

Stitt

Galindo-Leon

Pieper

et al. 2013

Journal of Neurophysiology

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In the superior colliculus (SC), visual afferent inputs from various sources converge in a highly organized way such that all layers form topographically aligned representations of contralateral external space. Despite this anatomical organization, it remains unclear how the layer-specific termination of different visual input pathways is reflected in the nature of visual response properties and their distribution across layers. To uncover the physiological correlates underlying the laminar organization of the SC, we recorded multiunit and local field potential activity simultaneously from all layers with dual-shank multichannel linear probes. We found that the location of spatial receptive fields was strongly conserved across all visual responsive layers. There was a tendency for receptive field size to increase with depth in the SC, with superficial receptive fields significantly smaller than deep receptive fields. Additionally, superficial layers responded significantly faster than deeper layers to flash stimulation. In some recordings, flash-evoked responses were characterized by the presence of gamma oscillatory activity (40–60 Hz) in multiunit and field potential signals, which was strongest in retinorecipient layers. While SC neurons tended to respond only weakly to full-field drifting gratings, we observed very similar oscillatory responses to the offset of grating stimuli, suggesting gamma oscillations are produced following light offset. Oscillatory spiking activity was highly correlated between horizontally distributed neurons within these layers, with oscillations temporally locked to the stimulus. Together, visual response properties provide physiological evidence reflecting the laminar-specific termination of visual afferent pathways in the SC, most notably characterized by the oscillatory entrainment of superficial neurons.

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Section: Visual Responses Display Laminar Specificitymentioning

confidence: 91%

Laminar profile of visual response properties in ferret superior colliculus

Stitt

Galindo-Leon

Pieper

et al. 2013

Journal of Neurophysiology

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“…1D, top arrow). (2) Following the onset of the axonal potential by Ͻ1 ms, a fast-rising negative-going potential (10 -90% rise time ϭ 0.47 ms for sustained, 0.43 for transient) occurs, reflecting a focal monosynaptic depolarization (Swadlow and Gusev, 2000;Bereshpolova et al, 2006) (Fig. 1D, bottom arrow).…”

Section: The Impact Of An Lgnd Impulse On the Visual Cortexmentioning

confidence: 99%

“…First, we classified each LGNd neuron as sustained or transient using traditional receptive field analyses, and then we measured the dynamics of the synapses generated by each of these neurons using the method of spike-triggered current sourcedensity (CSD) analysis. This approach enables assessment of monosynaptic currents generated by impulses of single presynaptic afferents to the topographically aligned region of cortex Bereshpolova et al, 2006;Jin et al, 2008). We found that TC synapses of sustained and transient geniculocortical neurons generated monosynaptic currents that differed significantly in their dynamics and in their sublaminar organization within layer 4.…”

Section: Introductionmentioning

confidence: 97%

The Impact of an LGNd Impulse on the Awake Visual Cortex: Synaptic Dynamics and the Sustained/Transient Distinction

Stoelzel¹,

Bereshpolova²,

Gusev³

et al. 2008

J. Neurosci.

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We used spike-triggered current source-density analysis to examine axonal and postsynaptic currents generated in the visual cortex of awake rabbits by spontaneous spikes of individual sustained and transient dorsal lateral geniculate nucleus (LGNd) neurons. Using these data, we asked whether sustained/transient sensory responses are related to short-term synaptic dynamics at the thalamocortical synapse. Most sustained (34 of 40) and transient (24 of 25) neurons generated axonal and monosynaptic responses in layer 4 and/or 6 of the aligned cortical domain, with input from transient neurons arriving ϳ0.3 ms earlier and 100 -200 m deeper. Postsynaptic cortical responses generated by both thalamic cell classes were reduced in amplitude after a preceding impulse and slowly recovered over a period of Ͼ750 ms. We interpret this to reflect interval-dependent recovery from chronic depression at the thalamocortical synapse, caused by significant spontaneous firing of LGNd cells (ϳ8 Hz). Surprisingly, postsynaptic cortical responses generated by spontaneous spikes of sustained thalamic neurons were more depressed than those of transient neurons. This difference was seen both in layers 4 and 6. The depression saturated rapidly with multiple preceding impulses, and postsynaptic responses generated by sustained neurons during maintained visual stimulation remained sufficiently robust to allow a sustained flow of information to the cortex. Our results indicate a relationship between the sensory response properties of thalamic neurons and the short-term dynamics of their synapses, and suggest that cortical recipients of sustained and transient thalamic inputs will differ considerably in their response modulation by prior impulse activity.

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“…1 from Swadlow and Gusev 2000). The early waveform (i.e., the AxTP) reflects the incoming action potential, whereas the later negativity, termed the focal synaptic negativity (FSN), is a postsynaptic field response (Bereshpolova et al 2006;Swadlow and Gusev 2000). In experiments in which the array was used to record cortical activity, we obtained data from 45 thalamic units and 153 cortical recording sites, 109 of which yielded an AxTP.…”

Section: Spike-triggered Averagesmentioning

confidence: 99%

“…The spike-triggered-averaging approach assumes that the evoked activity in the cortex reflects the influence of the single thalamic neuron that is being recorded (Bereshpolova et al 2006;Swadlow and Gusev 2000). As noted by Swadlow and colleagues, in the case of AxTPs, the waveforms are so brief that they are unlikely to be produced by multiple cells, which would have to fire virtually simultaneously.…”

Section: Bmentioning

confidence: 99%

Thalamocortical Conduction Times and Stimulus-Evoked Responses in the Rat Whisker-to-Barrel System

Simons

Carvell²,

Kyriazi³

et al. 2007

Journal of Neurophysiology

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Simons DJ, Carvell GE, Kyriazi HT, Bruno RM. Thalamocortical conduction times and stimulus-evoked responses in the rat whiskerto-barrel system. J Neurophysiol 98: 2842-2847, 2007. First published September 5, 2007 doi:10.1152/jn.00800.2007. Studies of the rodent whisker system indicate that somatosensory cortical circuitry operates at a millisecond timescale to transform sensory afferent signals from the thalamus. We measured axon conduction times and whisker-evoked responses of 48 thalamocortical (TC) neurons in the rat whisker-to-barrel pathway. Conduction times were derived from spike-triggered averages of local field potentials evoked in layer 4 cortical whisker-related barrels by the spontaneous firing of individual topographically aligned neurons in the ventral posterior medial thalamus. Conduction times varied fourfold, from 0.31 to 1.34 ms, and faster conducting TC neurons responded earlier and more robustly to controlled whisker deflections. Early arrival of highly responsive TC inputs, thought to contact inhibitory barrel neurons preferentially, could prime the cortical network, rendering it more selective for later-arriving signals.

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The Impact of a Corticotectal Impulse on the Awake Superior Colliculus

Cited by 32 publications

References 68 publications

Laminar profile of visual response properties in ferret superior colliculus

Laminar profile of visual response properties in ferret superior colliculus

The Impact of an LGNd Impulse on the Awake Visual Cortex: Synaptic Dynamics and the Sustained/Transient Distinction

Thalamocortical Conduction Times and Stimulus-Evoked Responses in the Rat Whisker-to-Barrel System

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