Background: To compare the efficiency of preloaded vs manually-loaded IOL (P-IOL vs M-IOL) delivery systems in cataract surgery in a biggest ambulatory surgery center of Northwestern China.Methods: A total number of 200 cases were included in this prospective observational study. Time and motion data were collected in one or two-operating rooms (1-OR or 2-ORs) scenario. An efficiency and revenue implications of introducing a preloaded delivery system for IOLs in cataract surgery model was used to estimate the change in cataract throughput and hospital revenue through translating from the M-IOL delivery system to the P-IOL system. Results: In the 1-OR scenario, the mean total case time was 16.9 minutes using P-IOL, which was 7.7% reduction compared with M-IOL (P < 0.01). In the 2-ORs scenario, the mean total surgeon time was 10.8 minutes using P-IOL, which was 7.8% reduction compared with M-IOL (P < 0.05). By switching from M-IOL to P-IOL, annual throughput will increase by 5.2% (960 cases) in the 1-OR scenario and 7.7% (1440 cases) in the 2-ORs scenario, which accompanying with an increase in revenue by approx. 284,352 USD in the 1-OR scenario and approx. 426,528 USD in the 2-ORs scenario. Conclusion: This is the first report of comparison with two IOL delivery systems in China by using different setting of scenario. IOL delivery with preloaded systems is time-saving in both 1-OR and 2-ORs scenario. Moreover, switching from the M-IOL delivery system to the P-IOL system holds potential to increase cataract throughput and hospital revenue.