The impact of acute kidney injury in diabetes mellitus

Johnson, Faye M.; Phillips, Dafydd; Talabani, Bnar; Wonnacott, Alexa; Meran, Soma; Phillips, Aled Owain

doi:10.1111/nep.12649

Cited by 21 publications

(17 citation statements)

References 35 publications

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“…Our results were consistent with the data in the current literature: 60 of the 68 analysed drugs were known to cause kidney damage (i.e. as described in the Summary of Product Characteristics or in the Micromedex drug information database) .…”

Section: Discussionsupporting

confidence: 92%

The drugs that mostly frequently induce acute kidney injury: a case − noncase study of a pharmacovigilance database

Pierson-Marchandise

Gras

Moragny

et al. 2017

Brit J Clinical Pharma

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Section: Discussionsupporting

confidence: 92%

The drugs that mostly frequently induce acute kidney injury: a case − noncase study of a pharmacovigilance database

Pierson-Marchandise

Gras

Moragny

et al. 2017

Brit J Clinical Pharma

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“…Studies in rats with streptozotocin (STZ)-induced type 1 diabetes (T1DM) indicated that diabetic rats had significantly greater histological damage, tubular apoptosis, and long-term fibrosis and higher mortality after ischemia than nondiabetic rats 3 .The mechanisms underlying this susceptibility are not well understood. Previous work has demonstrated an increase in the expression of certain inflammatory cytokines in the diabetic kidney 2,3 . In this study, we showed that the pathological changes of kidney were increased, the apoptosis was enhanced, the IL-6 and TNF-α were raised up in the diabetic I/R model.…”

Section: Discussionmentioning

confidence: 99%

“…An increased susceptibility of the diabetic kidney to ischemic injury has been reported in diabetics [1][2][3] . The pathomechanisms of acute kidney ischemia/reperfusion (I/R)…”

Section: Introducionmentioning

confidence: 99%

Toll-like receptor 7 involves the injury in acute kidney ischemia/reperfusion of STZ-induced diabetic rats

et al. 2016

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PURPOSE:To determine whether Toll-like receptor 7 (TLR7) is the potential targets of prevention or progression in the renal ischemia/ reperfusion (I/R) injury of STZ-induced diabetic rats. METHODS:Thirty six Sprague-Dawley rats were randomly arranged to the nondiabetic (ND) or diabetic group (DM), with each group further divided into sham (no I/R injury), I/R (ischemia-reperfusion) and CD (given by Chloroquine) group. Preoperatively, Chloroquine (40 mg/kg, intraperitoneal injection.) was administrated 6 days for treatment group. I/R animals were subjected to 25 min of bilateral renal ischemia. Renal function, histology, apoptosis, cytokines, expression of TLR7, MyD88 and NF-κB were detected. RESULTS:The serum levels of blood urea nitrogen, creatinine, IL-6 and TNF-α, apoptotic tubular epithelial cells, expression of TLR7, MyD88 and NF-κB were significantly increased in DM+I/R group, compared with ND+I/R group (p<0.05). All these changes were further improved by TLR7 inhibition Chloroquine except Paller scores (p<0.05). CONCLUSION:Toll-like receptor 7 inhibition attenuates the acute renal ischemia/reperfusion injury of STZ-induced diabetic in SD rats.

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“…Unlike our results, the results of Johnson F. et al showed that AKI was diagnosed in 403 patients, 20.5% of whom were diabetic patients. Short-term renal function recovery was greater in diabetic patients (87% vs. 63%, p=0.001) and the development of advanced CKD was lower (14%) in comparison with the non-diabetic patients(23). In our study, a better renal function recovery at the late onset of RRT in non-diabetic patients requires additional testing of long-term renal recovery and the number of episodes of AKI in these patients comparing to the patients at the risk of diabetes and the diabetics.…”

mentioning

confidence: 90%

Early initiation of renal replacement therapy improves survival in patients with acute kidney injury

et al. 2021

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Introduction/Objective: Defining renal replacement therapy (RRT) initiation in critically ill patients with acute kidney injury (AKI) has become an imperative for nephrologists and intensivists. The primary objective of this study was 28-day patient survival and the secondary objective was renal function recovery. Methods: We performed a single-center retrospective study of 385 surgical and non-surgical patients with AKI and episode of AKI in chronic kidney disease who were admitted to the Emergency Center between 2014 and 2017 and received RRT. Patients with Kidney Disease Improving Global Outcomes stage 2 AKI and/or volume overload were assigned to the "early" group with RRT start within 24h of the diagnosis; patients with poor response to conservative treatment or evidence of clinical complications associated with AKI were assigned to the "late" RRT group. Results: Based on the retrospective analysis we found that 241 (62.6%) patients received "early" RRT within 24h. Patients in the "early" RRT group had significantly higher survival compared to the "late" RRT group (63.9% vs. 36.1%; p=0.001). The "early" RRT group had more patients with renal function recovery (56.8%), but without statistical significance (p=0.514). The patients who started RRT within 24 hours with the SOFA score of 1-3 were twice likely to recover renal function in relation to the patients with the SOFA score of 4 or higher (OR=2,01; 95%CI (1,37-2,95); p<0,001), while septic patients a 62% lower chance of renal function recovery in relation to non-septic patients (OR=0,38; 95%CI (0,18-0,82); p=0,013). In the "late" RRT group it was found that non-diabetic patients had 3.8 times greater chance for renal function recovery compared to diabetic patients (OR=3.53; 95% CI [1.27-9.83]; p=0.016). Conclusions: Patients with early initiation of RRT had significantly improved 28-day survival.

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The impact of acute kidney injury in diabetes mellitus

Abstract: Although acute mortality is comparable following an AKI episode in diabetic patients compared with that associated with AKI in a non-diabetic cohort, for those surviving the acute episode, its impact on renal function is significantly less than in a non-diabetic group.

Cited by 21 publications

References 35 publications

The drugs that mostly frequently induce acute kidney injury: a case − noncase study of a pharmacovigilance database

The drugs that mostly frequently induce acute kidney injury: a case − noncase study of a pharmacovigilance database

Toll-like receptor 7 involves the injury in acute kidney ischemia/reperfusion of STZ-induced diabetic rats

Early initiation of renal replacement therapy improves survival in patients with acute kidney injury

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