The impact of age, BMI and sex hormone on aging males’ symptoms and the international index of erectile function scores

Yu, Xiaohua; Zhao, Jing; Zhang, Shucheng; Zheng, Jun-Biao; Zheng, Li; Liang, Guangchao; Shi, Huijuan; Zhou, Weijin; Zhu, Qianxi

doi:10.1080/13685538.2017.1361399

Cited by 18 publications

(9 citation statements)

References 31 publications

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“…This study revealed that when age and BMI were included into multiple regression models, LH was the strongest predictor related to total AMS score (including somatic and sexual symptoms), IPSS and IIEF‐5. However, TT, FT and Bio‐T failed to yield any additional predicting information, which was consistent with previous studies (Li et al.,2016; Peel et al.,2020; Yu et al.,2017). SHBG also had positive correlations with total AMS and sexual symptom score.…”

Section: Discussionsupporting

confidence: 91%

Association of hypogonadism symptoms and serum hormones in aging males

et al. 2021

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The association between hypogonadism symptoms and the levels of serum hormones are still in debate. To investigate the relationship between hypogonadism symptoms and serum hormones in middle‐aged and elderly Chinese men, this community‐based cross‐sectional study was conducted based on a total of 965 ageing men. The ageing males’ symptom (AMS) scale, International Index of Erectile Function‐5 (IIEF‐5), International Prostate Symptom Score (IPSS) questionnaires and related variables were assessed. Blood tests for total testosterone (TT), sex hormone‐binding globulin (SHBG) and luteinising hormone (LH) were performed. Serum level of free testosterone (FT) and bioavailable testosterone (Bio‐T) was calculated. The mean age was 56.34 ± 8.85 years. Total AMS score was significantly associated with all five serum hormones (LH: p < 0.001; SHBG: p < 0.001; TT: p =.043; FT: p = 0.007; Bio‐T: p < 0.001). We identified sexual and somatic symptoms were obviously related to five serum hormones, while psychological symptoms seemed to have no association with serum hormones. After adjusting for age and BMI, multiple linear regression analysis indicated that LH had positive correlations with total AMS score, somatic and sexual symptom score (p < 0.05). In conclusion, LH and SHBG had the strongest correlation hypogonadism and might be used as early predictors for symptomatic hypogonadism in the near future.

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Section: Discussionsupporting

confidence: 91%

Association of hypogonadism symptoms and serum hormones in aging males

et al. 2021

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“…Interestingly, we found that IIEF-5 scores or erectile dysfunction was not related to hypoandrogenemia. In this line, previous authors have shown that androgen levels fail to yield predicting information about erectile function when age is adjusted (36), and that low testosterone levels, as an independent impact factor, is relevant only for men with severe erectile dysfunction (37). In addition, it is important to bear in mind that sexual dysfunction in men with obesity is a multifactorial condition and that psychological and sociocultural factors may play a relevant role, independently of testosterone concentrations (38).…”

Section: Discussionmentioning

confidence: 98%

Cross‐Sectional, Primary Care–Based Study of the Prevalence of Hypoandrogenemia in Nondiabetic Young Men with Obesity

Molina‐Vega

Asenjo-Plaza²,

García‐Ruiz³

et al. 2019

Obesity

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Objective Obesity‐associated hypoandrogenemia is increasing in parallel to the obesity epidemic. The prevalence of hypoandrogenemia in nondiabetic young men with obesity is not known. This study aimed to evaluate the prevalence of hypoandrogenemia and associated risk factors in this population. Methods This cross‐sectional study included 266 nondiabetic men < 50 years of age with obesity who were referred from primary care. Total testosterone (high‐performance liquid chromatography mass spectrometry), sex hormone–binding globulin, free testosterone (FT), luteinizing hormone (LH), high‐sensitivity C‐reactive protein, and homeostatic model assessment of insulin resistance were determined. Body composition and erectile function were also assessed. Hypoandrogenemia was defined as FT level < 70 pg/mL. Results Subnormal FT concentrations were found in 25.6% of participants. Hypoandrogenemia prevalence was different along the BMI continuum, being > 75% in individuals with BMI ≥ 50 kg/m2. A multivariate regression analysis indicated that increasing BMI (P < 0.001), age (P = 0.049), and reduced LH levels (P = 0.003) were independent risk factors for hypoandrogenemia. Conclusions In a primary care–based cohort of nondiabetic young men with obesity, hypoandrogenemia was a very prevalent finding and was directly associated with adiposity. Obesity, age, and reduced LH levels were independent risk factors associated with hypoandrogenemia. Further prospective studies are needed to evaluate the long‐term consequences of hypoandrogenemia in this population.

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“…Our study showed that the ED group had an increased age as compared with the non-ED group, and subsequent logistic regression analysis indicated age was regarded as an independent risk factor for ED. The studies by Ahn et al and Yu et al similarly confirmed the influence of increased age on ED, and each year of increase in age caused a decrease in the IIEF-5 score, meaning a more difficult erection condition [ 24 , 25 ]. The decreases in coital frequency, physical activity, vascular function, and testosterone levels and increases in oxidative stress, inflammation, and glucose metabolic abnormalities with age played a vital role in the development of ED [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 92%

Association between Frailty and Erectile Dysfunction among Chinese Elderly Men

Sun

Zhao

et al. 2020

BioMed Research International

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Objective. This study is aimed at assessing association between frailty and erectile dysfunction among Chinese elderly men. Methods. This community-based study was conducted with a sample of 341 Chinese elderly men (aged 60 to 83 years old) in Fuyang City (Anhui Province, China). Each of the participants completed a standard questionnaire, including demographics (age, height, weight, yearly income, educational status, comorbidity, lifestyle factors, etc.), medical and sexual history, and the Chinese version of Tilburg Frailty Indicator (TFI) and International Index of Erectile Function-5 (IIEF-5) for assessing frailty and erectile dysfunction (ED). Results. The prevalence of ED and frailty in Chinese elderly men was 77.13% and 68.04%, respectively. Compared with the non-ED group, the ED group had increased age, spouse’s age, BMI, prevalence of diabetes, and scores of TFI and lower yearly income, educational levels, and ratio of irregular intercourse (less than once per week) (all P<0.05). Multivariate analysis indicated that age (OR: 0.860, 95% CI: 0.763-0.969), diabetes (OR: 0.330, 95% CI: 0.165-0.661), irregular intercourse (OR: 3.416, 95% CI: 1.874-6.229), and scores of TFI (OR: 0.906, 95% CI: 0.846-0.970) were regarded as independent risk factors for ED (all P<0.05). And after adjusting for age, the TFI score had a negative significant association with the IIEF score (r=−0.134, P=0.013). Conclusion. This study confirmed the strong associations between ED and frailty among elderly men. Sexual health care for elderly men with ED should be assessed and taken addressed on the multidimensional assessments of frailty.

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The impact of age, BMI and sex hormone on aging males’ symptoms and the international index of erectile function scores

Abstract: CFT, Bio-T and SHBG failed to yield any additional predicting information when age was adjusted. To improve the male reproductive health, future research should pay more attention on aging-related comorbidities and how to improve general wellness.

Cited by 18 publications

References 31 publications

Association of hypogonadism symptoms and serum hormones in aging males

Association of hypogonadism symptoms and serum hormones in aging males

Cross‐Sectional, Primary Care–Based Study of the Prevalence of Hypoandrogenemia in Nondiabetic Young Men with Obesity

Association between Frailty and Erectile Dysfunction among Chinese Elderly Men

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