The Impact of Alpha-lipoic Acid Dietary Supplementation on Growth Performance, Liver and Bone Efficiency, and Expression Levels of Growth-Regulating Genes in Commercial Broilers

Evaluation of the Effect of Some Antioxidants for Controlling Aflatoxicosis in Broiler Chickens

“…The addition of alpha-lipoic acid or Agrimos to aflatoxicated diet significantly decreases serum ALT and GGT at 30 days when compared to the control positive group but they only made a numerical improvement in serum AST when compared to the control positive group. These results agreed to some extent with that reported by Sakr et al (2020) who demonstrated that alpha-lipoic acid supplementation (50, 100 and 200 mg/kg diet) significantly reduced (p≤0.05) serum ALT, AST, and GGT when compared with the control group. And also agreed with Chen et al (2020) who observed that compared with the heat stress group, dietary supplementation of manan oligo saccharides reduced serum ALT activity (P < 0.05) in broilers challenged with heat stress.…”

“…This result matched with Gowda et al, ( 2008) who found that the addition of turmeric powder at a dose of 74 mg /kg diet to the AFB1( 1000 ppb) diet significantly enhanced weight gain, and with Cruz et al (2019) who reported that the addition of curcumin (0.2%) to the diet containing Aaflatoxin significantly reduced its adverse effects on these performance parameters, and with Darwish and El shukary, (2020) who found that using turmeric powder supplement in fayoumi broiler feed improved body weight gain and FCR, also Attia et al (2016) observed that supplementation of mannan oligosaccharides at 2 g/kg diet-induced recovery in growth performance of groups challenged by 200 ppb AF for 21 days; Yildirim et al (2011) evaluated the effect of glucomannan in broilers challenged by aflatoxixosis 2 mg/kg for 21 days and demonstrated that the weight gains and feed efficiency were partially restored; Ibrahim et al (2021) who found that The addition of 0.1% agrimos to broilers has a positive effect on growth parameters, carcass traits without adverse effect on broiler immunity; Abdel-raheem and Esmail, (2012) found that quils fed diets with medium MOS level (3 g /kg feed) recorded significant (P < 0.05) improvements in body weight, weight gain and feed conversion efficiency, The addition of alpha-lipoic acid (0.03%) didn't significantly increase BW or BWG, but only made a significant decrease (P<0.05) of FCR as compared to the nontreated aflatoixcated group. These agreed with Sakr et al (2020) who indicated that the addition of alpha lipoic acid (50,100 and 200 mg/kg diet) significantly (p≤0.05) improved FCR results when compared with the control group and in contrast to Mourad et al (2020) who found that aflatoxicated treated with lipoic chickens showed a significant increase of body weight when compared to aflatoxicated group at the end of the experiment. This may be due to the difference in aflatoxin b1 percentage in the total aflatoxin used as in our present study aflatoxin b1 was 97.19% of total 100ppb and the rest was aflatoxin b2(2.8%).…”

EFFECT OF L-Carnitine AND Α-Lipoc ACID ON PRODUCTIVE PERFORMANCE AND PHYSIOLOGICAL STATUS OF BROILERS

“…It is also an antioxidant that acts as a coenzyme in the metabolism of carbohydrates in broiler chickens (Packer et al, 2001). These results agreed with Sakr et al (2020) and Lu et al (2017b). On another hand, Ou et al (2023) and El-Rayes et al (2020) found that body weight was decreased by supplementation of lipoic acid.…”