The Impact of Angiogenesis in the Most Common Salivary Gland Malignant Tumors

Pouloudi, Despoina; Sotiriadis, Aristoteles; Theodorakidou, Margarita; Sarantis, Panagiotis; Pergaris, Alexandros; Karamouzis, Michalis V.; Theocharis, Stamatios

doi:10.3390/ijms21249335

Cited by 6 publications

(7 citation statements)

References 66 publications

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“…9,24 The primary element affecting vascular density in macroscopic tumours is the metabolic requirement, which usually increases with tumour growth. 25,26 In the current study, salivary and laryngeal ACC vasculature generally formed a ring of capillaries surrounding tumour nests and stained positively in a solid pattern rather than in a cribriform or tubular pattern. The present study agrees with Moghadam, et al (2015) 27 , who found that SACC vasculature commonly formed a capillary ring surrounding tumour nests.…”

Section: Discussionsupporting

confidence: 45%

Immunohistochemical analysis of CD34 and PCNA expression in salivary and laryngeal adenoid cystic carcinoma

El-Azab

Alqalshy

El-Rahman

et al. 2021

ijhs

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Background/purpose: Adenoid cystic carcinomas (ACC) are malignant tumors that affect major and minor salivary glands. LACC is an extremely rare location for this type of tumour. This study describes the immunohistochemical analysis of CD34 and PCNA expression in salivary and laryngeal ACC. Materials and methods: The study included 40 formalin-fixed paraffin-embedded blocks were used, 20 of them were previously diagnosed as SACC, and 20 as LACC. All sections were stained with hematoxylin and eosin (H&E) and immunohistochemical marker to detect CD34 and PCNA protein. Results: Regarding the expression of CD34, SACC had recorded the highest mean area % (31.58), while LACC recorded the lowest mean area % (14.25) and the comparison revealed that there was a highly significant difference between these lesions where P value was (<0.001) concerning the expression of PCNA, SACC had recorded the highest mean area % (36.28), while LACC recorded the lowest mean area % (20.7) and the comparison revealed that there was a highly significant difference between these lesions where P value was (<0.001). Conclusions: immunohistochemical analyses presented here indicated that LACC tends to nonaggressive oncological behavior and angiogenesis when compared to SACC.

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Section: Discussionsupporting

confidence: 45%

Immunohistochemical analysis of CD34 and PCNA expression in salivary and laryngeal adenoid cystic carcinoma

El-Azab

Alqalshy

El-Rahman

et al. 2021

ijhs

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“…PI3K signaling is usually intensified by the loss of function of the negative regulation of PTEN, whose main substrate is PIP3, thus enhancing the activation of AKT [ 84 , 85 ]. Correspondingly, several studies denote VEGF in respect to the tumor microenvironment (TME) as a prognostic factor commensurate with tumor size, aggressive behavior and metastasis, and cell growth [ 85 , 86 , 87 ]. Basically, TME is characterized by heterogeneous, aberrant vasculature derived from an imbalance among pro- and non-angiogenic factors [ 88 , 89 ].…”

Section: Angiogenetic Behavior As a Consequence Of Pc/ec Crosstalkmentioning

confidence: 99%

A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland

Cucu

Nicolescu

2021

Dentistry Journal

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The salivary gland (SG) microvasculature constitutes a dynamic cellular organization instrumental to preserving tissue stability and homeostasis. The interplay between pericytes (PCs) and endothelial cells (ECs) culminates as a key ingredient that coordinates the development, maturation, and integrity of vessel building blocks. PCs, as a variety of mesenchymal stem cells, enthrall in the field of regenerative medicine, supporting the notion of regeneration and repair. PC-EC interconnections are pivotal in the kinetic and intricate process of angiogenesis during both embryological and post-natal development. The disruption of this complex interlinkage corresponds to SG pathogenesis, including inflammation, autoimmune disorders (Sjögren’s syndrome), and tumorigenesis. Here, we provided a global portrayal of major signaling pathways between PCs and ECs that cooperate to enhance vascular steadiness through the synergistic interchange. Additionally, we delineated how the crosstalk among molecular networks affiliate to contribute to a malignant context. Additionally, within SG microarchitecture, telocytes and myoepithelial cells assemble a labyrinthine companionship, which together with PCs appear to synchronize the regenerative potential of parenchymal constituents. By underscoring the intricacy of signaling cascades within cellular latticework, this review sketched a perceptive basis for target-selective drugs to safeguard SG function.

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“…El crecimiento de un tumor, la invasión y las metástasis dependen de la angiogénesis, que es una característica distintiva del cáncer [10][11] . El método más común para evaluar la actividad de angiogénesis consiste en medir la cantidad de vasos en un tumor, lo que nos da una estimación de la densidad microvascular 11 . Para evaluar la angiogénesis se utilizan distintos marcadores, como CD34, CD31, CD105 (endoglobin) y VEGF (vascular endothelial growth factor) 11 .…”

Section: Introductionunclassified

“…El método más común para evaluar la actividad de angiogénesis consiste en medir la cantidad de vasos en un tumor, lo que nos da una estimación de la densidad microvascular 11 . Para evaluar la angiogénesis se utilizan distintos marcadores, como CD34, CD31, CD105 (endoglobin) y VEGF (vascular endothelial growth factor) 11 .…”

Section: Introductionunclassified

Expresión inmunohistoquímica de Ki67 y CD34 como marcadores de proliferación y angiogénesis en el carcinoma mucoepidermoide de glándulas salivales humanas

Samar Romani,

Ávila Uliarte,

Fonseca Acosta

et al. 2023

Rev. Fac. Odontol.

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Las neoplasias de las glándulas salivales son tumores raros y con diferente potencial maligno. Corresponden a menos del 2% de todas las neoplasias humanas y el 3 a 4% de los tumores de cabeza y cuello. Su diagnóstico se enriquece con la inmunohistoquímica. Basándonos en este antecedente investigamos la asociación entre los marcadores Ki67 (proliferación) y CD34 (angiogénesis) y el grado histológico del carcinoma mucoepidermoide (CME). Este estudio inmunohistoquímico se realizó en casos de 10 pacientes seleccionados de una base de datos de tumores salivales de nuestro equipo de trabajo correspondiente al período 1995-2022. Los tumores se clasificaron como de baja y alta proliferación con un índice de marcación de Ki67 de ≤15% y >30%, respectivamente. La marcación de CD34 se calificó como positiva (>de 5 vasos sanguíneos marcados en el campo de visión) o negativa (<de 5 vasos sanguíneos marcados en el campo de visión) en tumores de alto y bajo grado, respectivamente. Consideramos que la expresión cuantitativa del índice proliferativo tumoral se asocia con su grado histológico de malignidad y el diferente grado de marcación de CD-34 en el CME salival, factores vinculados a su pronóstico.

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The Impact of Angiogenesis in the Most Common Salivary Gland Malignant Tumors

Cited by 6 publications

References 66 publications

Immunohistochemical analysis of CD34 and PCNA expression in salivary and laryngeal adenoid cystic carcinoma

Immunohistochemical analysis of CD34 and PCNA expression in salivary and laryngeal adenoid cystic carcinoma

A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland

Expresión inmunohistoquímica de Ki67 y CD34 como marcadores de proliferación y angiogénesis en el carcinoma mucoepidermoide de glándulas salivales humanas

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