The impact of anxiety on the neural processing of respiratory sensations

Leupoldt, Andreas von; Chan, Pei-Ying S.; Bradley, Margaret M.; Lang, Peter; Davenport, Paul W.

doi:10.1016/j.neuroimage.2010.11.050

Cited by 65 publications

(64 citation statements)

References 39 publications

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“…These relationships were not observed in the healthy control subjects. The finding about the healthy controls is in line with the previous study by von Leupoldt et al (2011aLeupoldt et al ( , 2011b where they found the early RREP peaks unaffected by anxiety in healthy individuals (von Leupoldt et al, 2011a). The present study extends the result of the previous study with the seemingly shorter information processing speed for the early peaks in those with more level of breathlessness under the GAD disease state.…”

Section: Discussionsupporting

confidence: 91%

Respiratory perception measured by cortical neural activations in individuals with generalized anxiety disorder

Chan

Leupoldt

Liu

et al. 2014

Respiratory Physiology & Neurobiology

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There has been evidence for the effect of anxiety on the neural processing of respiratory sensation using the respiratory-related evoked potentials (RREP) elicited by inspiratory occlusions. This study tested the RREP elicited by inspiratory occlusions in a group of outpatients with generalized anxiety disorder (GAD) and a group of healthy controls. We hypothesized that the RREP P3 peak would be modulated in the GAD patients. A RREP oddball paradigm of 150-ms inspiratory occlusion protocol was used in 15 GAD patients and 11 healthy adults with normal lung functions. The RREP was recorded with a 40-channel electroencephalography (EEG) system. A minimum of 100 occlusions was collected for data analysis. We found that the averaged P3 latency of the GAD patients was significantly longer than the P3 latency of the healthy controls. In addition, the GAD group showed significantly reduced P3 amplitudes compared to the control group. No group differences in latency and amplitudes were found for earlier RREP components. These results demonstrated that a delayed and reduced attention peak (P3) is present in patients with GAD. This suggests that GAD as a disease state modulates the higher order processing of respiratory perception.

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Section: Discussionsupporting

confidence: 91%

Respiratory perception measured by cortical neural activations in individuals with generalized anxiety disorder

Chan

Leupoldt

Liu

et al. 2014

Respiratory Physiology & Neurobiology

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“…Indeed, their amplitudes correlate with the stimulus magnitude (Davenport et al, 2007;Davenport, 1997, 1999) but not with attention (Chan and Davenport, 2009;Webster and Colrain, 2000b) nor with emotion (von Leupoldt et al, 2011Leupoldt et al, , 2010b, consistent with the present study. This suggests that the peripheral encoding of sensory signals and the initial cortical activations are not affected by emotion.…”

Section: Effect Of Unpleasant Emotions On Rrep Componentssupporting

confidence: 90%

“…The competitive effect of unpleasant IAPS pictures for attentional resources has previously been reported in other sensory modalities (KenntnerMabiala et al, 2008;Mini et al, 1995;Muller et al, 2008;Ring et al, 2013). Additionally, when attention is focused on the respiratory stimulus the amplitude of N1 S1 is not modified by viewing unpleasant IAPS pictures or by anxiety state (von Leupoldt et al, 2011Leupoldt et al, , 2010b. Interestingly, our findings as well as results from previous studies investigating neurophysiological substrates underlying the emotion-induced over-perception of sensations report a decrease in the brain activity related to the stimulus, which seems inconsistent with over-perception.…”

Section: Effect Of Unpleasant Emotions On Rrep Componentsmentioning

confidence: 55%

Negative emotional stimulation decreases respiratory sensory gating in healthy humans

Chenivesse

Chan

Tsai

et al. 2014

Respiratory Physiology & Neurobiology

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We tested the hypothesis that negative emotions decrease the respiratory-related evoked potentials (RREP) sensory gating (RSG). RREP were elicited by paired inspiratory occlusions. RSG was calculated as the difference in the averaged RREP peak N1 amplitude between the second (S2) and the first occlusion (S1). RSG was compared between unpleasant and neutral emotional conditions elicited by viewing affective pictures from the IAPS system in thirteen healthy adults. Results are expressed as median [min; max]. Compared to neutral pictures, viewing unpleasant pictures decreased the RREP N1(S1) amplitude (-3.37 μV [-4.62; -1.37] versus -4.59 μV [-6.08; -1.36]; p=0.017) but not the RREP N1(S2) amplitude (-0.26 [-3.24; 2.36] versus -0.7 [-1.54; 3.6]; p = 0.68), and reduced the difference score S2-S1 (3.73 μV [0; 5.82] versus 4.79 μV [3; 6.2]; p = 0.038). We concluded that a negative emotional stimulation could attract subject's attention to the detriment of the respiratory sensory inputs and produced an overall decrease in the RSG. This latter finding might participate in an over-perception of repeatedly presented respiratory stimuli.

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“…First, there is a well-established relationship between breathlessness and anxiety (von Leupoldt et al, 2011), which might promote a chronic stress response. Second, the perception of breathlessness is processed in the same parts of the cortico-limbic system (insula, amygdala and anterior cingulate cortex) as other aversive sensations such as pain, hunger and thirst (von Leupoldt et al, 2009), all of which are known to activate the stress response.…”

Section: Introductionmentioning

confidence: 99%

Salivary diurnal cortisol profiles in patients suffering from chronic breathlessness receiving supportive and palliative care services: A cross-sectional study

Ryan

Clow

Spathis³

et al. 2017

Psychoneuroendocrinology

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Salivary diurnal cortisol profiles in patients suffering from chronic breathlessness receiving supportive and palliative care services: a cross-sectional study.Psychoneuroendocrinology http://dx.doi.org/10. 1016/j.psyneuen.2017.01.025 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractChronic breathlessness is a common source of psychological and physical stress in patients with advanced or progressive disease, suggesting that hypothalamic-pituitary-adrenal (HPA) axis dysregulation may be prevalent. The aim of this study was to measure the salivary diurnal cortisol profile in patients receiving supportive and palliative care for a range of malignant and nonmalignant conditions and to compare the profile of those experiencing moderate-to-severe disability due to breathlessness against that of patients with mild/no breathlessness and that of healthy controls. Saliva samples were collected over two consecutive weekdays at 3, 6, and 12 hours after awakening in 49 patients with moderate-to-severe breathlessness [Medical Research Council (MRC) dyspnoea grade ≥3], 11 patients with mild/no breathlessness (MRC dyspnoea grade ≤2), and 50 healthy controls. Measures of breathlessness, stress, anxiety, depression, wellbeing and sleep were examined concomitantly. The diurnal cortisol slope (DCS) was calculated for each participant by regressing log-transformed cortisol values against collection time. Mean DCS was compared across groups using ANCOVA. Individual slopes were categorised into one of four categories: consistent declining, consistent flat, consistent ascending and inconsistent. Controlling for age, gender and socioeconomic status, the mean DCS was significantly flatter in patients with moderate-to-severe breathlessness compared to patients with mild/no breathlessness and healthy controls [F (2, 103) =45.64, p<0.001]. Furthermore, there was a higher prevalence of flat and ascending cortisol profiles in patients with moderate-to-severe breathlessness (23.4%) compared to healthy controls (0%). The only variable which correlated significantly with DCS was MRC dyspnoea grade (rs=0.29, p<0.05).These findings suggest that patients with moderate-to-severe breathlessness have evidence of HPA axis dysregulation and that this dysregulation may be related to the functional disability imposed by breathlessness.Richella Ryan 4

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The impact of anxiety on the neural processing of respiratory sensations

Cited by 65 publications

References 39 publications

Respiratory perception measured by cortical neural activations in individuals with generalized anxiety disorder

Respiratory perception measured by cortical neural activations in individuals with generalized anxiety disorder

Negative emotional stimulation decreases respiratory sensory gating in healthy humans

Salivary diurnal cortisol profiles in patients suffering from chronic breathlessness receiving supportive and palliative care services: A cross-sectional study

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