The impact of childhood trauma on cognitive functioning in patients recently recovered from a first manic episode: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM).

Bücker, Joana; Kozicky, Jan Marie; Torres, Ivan J.; Kauer-Sant’Anna, Márcia; Silveira, Leonardo Evangelista da; Bond, David J.; Lam, Raymond W.; Yatham, Lakshmi N.

doi:10.1016/j.jad.2012.11.022

Cited by 35 publications

(55 citation statements)

References 60 publications

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“…This was despite no significant symptomatic differences between the two groups at presentation. Significantly worse global functioning in adulthood was also identified in young adult patients with bipolar disorder who had experienced childhood trauma compared with those who had not (Bücker et al 2013). In addition, GAF scores and CTQ total scores were inversely correlated, indicating that greater childhood trauma was associated with greater functional impairment.…”

Section: Bipolar Disordermentioning

confidence: 88%

“…Using a split-version of the GAF that incorporated separate measures for functioning and symptoms, Larsson et al (2013b) also reported that total CTQ score and factor scores for emotional abuse/neglect and physical abuse were significantly associated with functioning scores in adulthood. Childhood maltreatment has also been associated with a younger age at illness onset (Bücker et al 2013) and more severe illness course in bipolar disorder (Etain et al 2013;Larsson et al 2013b). …”

Section: Bipolar Disordermentioning

confidence: 99%

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Childhood trauma and functional disability in psychosis, bipolar disorder and borderline personality disorder: a review of the literature

Cotter

Kaess

Yung

2014

Ir. j. psychol. Med.

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Objectives. We aimed to examine the association between childhood trauma and functional impairment in psychotic disorders, bipolar disorder and borderline personality disorder, to speculate on possible mechanisms that underlie this association and discuss the implications for clinical work.Methods. Narrative review of the peer-reviewed English language literature in the area.Results. High rates of childhood trauma in psychotic disorders, bipolar disorder and borderline personality disorder were identified. This was associated with impaired social and occupational functioning in both the premorbid and established phases of each of these psychiatric disorders over and above the deficits typically observed in these populations. Possible mechanisms mediating this relationship include neurocognitive deficits, insecure attachment, higher rates of comorbidities and problems with adherence and response to treatment. Conclusions.Routine clinical inquiry about childhood maltreatment should be adopted within mental health settings. This has potentially important treatment implications for identifying those individuals at elevated risk of functional disability. While there is no clear guidance currently available on how to target childhood trauma in the treatment of psychotic disorders, bipolar disorder or borderline personality disorder, there are several promising lines of enquiry and further research is warranted.

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Section: Bipolar Disordermentioning

confidence: 88%

Section: Bipolar Disordermentioning

confidence: 99%

Childhood trauma and functional disability in psychosis, bipolar disorder and borderline personality disorder: a review of the literature

Cotter

Kaess

Yung

2014

Ir. j. psychol. Med.

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“…Several features considered as severity markers (an earlier age at onset, rapid cycling, a history of suicidal behavior, increased rates of mood episodes and substance misuse) have consistently been associated with CT in BD . Concerning cognition, bipolar patients with a history of CT also present a poorer performance on attention, verbal memory and executive function domains, as well as a lower IQ …”

Section: Introductionmentioning

confidence: 99%

Impact of childhood trauma on cognitive profile in bipolar disorder

et al. 2017

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“…[1][2][3][4] These deficits are robustly associated with poor psychosocial outcomes, 5 and identifying predictors of cognitive impairment, particularly modifiable ones, is therefore a priority. To date, such predictors include medications, namely, mood stabilizers and atypical antipsychotics, 1,[6][7][8][9] substance abuse or dependence, 10 duration of illness and number of episodes, 1,6,11 childhood trauma, 12 and possibly obesity. 13 The deficits in the broad domains of attention, learning-memory, and executive function are also present even in patients with first-episode mania, where the variables associated with the progression of BD are fewer.…”

Section: Limitationsmentioning

confidence: 99%

“…39 The categorization of tasks was modelled closely after the Measurement and Treatment to Improve Cognition in Schizophrenia (commonly referred to as MATRICS) Consensus Cognitive Battery, which has been validated in BD. 40 The 6 domains assessed, and the respective measures within each domain, have been used in our previous work, 41,42 and were as follows: The raw scores obtained for each primary cognitive measure were converted into z scores (ranging from -4 to 4) based on demographics-adjusted normative data from test manuals. Domain scores for each subject were calculated as the average of z scores of the primary measures within each cognitive domain.…”

Section: Cognitive Assessmentmentioning

confidence: 99%

Neurocognitive Functioning in Overweight and Obese Patients with Bipolar Disorder: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)

et al. 2014

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Objective: Obesity is frequent in people with bipolar I disorder (BD I) and has a major impact on the course of the illness. Although obesity negatively influences cognitive function in patients with BD, its impact in the early phase of the disorder is unknown. We investigated the impact of overweight and obesity on cognitive functioning in clinically stable patients with BD recently recovered from their first manic episode. Method: Sixty-five patients with BD (25 overweight or obese and 40 normal weight) recently remitted from a first episode of mania and 37 age- and sex-matched healthy control subjects (9 overweight or obese and 28 normal weight) were included in this analysis from the Systematic Treatment Optimization Program for Early Mania (commonly referred to as STOP-EM). All subjects had their cognitive function assessed using a standard neurocognitive battery. We compared cognitive function between normal weight patients, overweight-obese patients, and normal weight healthy control subjects. Results: There was a negative affect of BD diagnosis on the domains of attention, verbal memory, nonverbal memory, working memory, and executive function, but we were unable to find an additional effect of weight on cognitive functioning in patients. There was a trend for a negative correlation between body mass index and nonverbal memory in the patient group. Conclusions: These data suggest that overweight-obesity does not negatively influence cognitive function early in the course of BD. Given that there is evidence for a negative impact of obesity later in the course of illness, there may be an opportunity to address obesity early in the course of BD.

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The impact of childhood trauma on cognitive functioning in patients recently recovered from a first manic episode: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM).

Cited by 35 publications

References 60 publications

Childhood trauma and functional disability in psychosis, bipolar disorder and borderline personality disorder: a review of the literature

Childhood trauma and functional disability in psychosis, bipolar disorder and borderline personality disorder: a review of the literature

Impact of childhood trauma on cognitive profile in bipolar disorder

Neurocognitive Functioning in Overweight and Obese Patients with Bipolar Disorder: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)

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