The impact of contact lens wear on ocular surface mucins using a novel clinical fluorescence imaging system

Read, Michael; Navascues‐Cornago, Maria; Keir, Nancy; Maldonado‐Codina, Carole; Morgan, Philip B.

doi:10.1016/j.clae.2019.08.004

Cited by 12 publications

(9 citation statements)

References 52 publications

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“…In summary, these studies that have examined the effect of contact lens wear on the tear film, and associations between contact lens discomfort and changes to the tear film biochemistry have found only a few possible associations. Symptomatic lens wearers may have decreased concentrations of β-2-microglobulin, proline-rich protein-4, lacritin, secretoglobin 1D1 [391] wax esters and wax ester to triacylglycerol ratio [213] and lower amounts of N-acetyl-D-glucosamine or sialic acid on their lid-wiper regions [425], but increased concentrations of secretoglobin 2A2, albumin, DMBT-1, prolactin-inducible protein [391], triacylglycerols [213] IL-17A [449] and LTB 4 [455] in their tears. However, what the association is between these changes and whether any are initiators of the symptomatology or merely bystanders in the events associated with symptomatology has yet to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…The mean MUC5AC concentration in tears was lower in the group that worked longer hours (office work using visual display terminals) compared to the group that worked shorter hours, but no significant MUC5AC concentration difference was related to dryness and other ocular symptoms [424]. Using fluorescein-labelled wheat germ agglutinin to stain N-acetyl-D-glucosamine and sialic acid sugar residues on the ocular surface (by inference the mucin glycocalyx), demonstrated that soft contact lens wear (disposable or frequent replacement lenses, no indication of whether the lenses were hydrogels or SiHys) decreased the levels of N-acetyl-D-glucosamine or sialic acid on the ocular surface [425]. The amount of N-acetyl-D-glucosamine or sialic acid has been correlated to the tear film breakup time [426].…”

Section: Contact Lenses and Alterations In Tear Mucinsmentioning

confidence: 99%

“…The amount of N-acetyl-D-glucosamine or sialic acid has been correlated to the tear film breakup time [426]. Symptomatic lens wearers (CLDEQ-8) had lower amounts of N-acetyl-D-glucosamine or sialic acid on their lid-wiper regions than asymptomatic lens wearers [425]. Another study examined goblet cell density, tear film breakup and mucin cloud height (the height of the top of the cloud-like mucin structure visible above the goblet cell opening) [427] of habitual SiHy lens wearers versus non-lens wearers.…”

Section: Contact Lenses and Alterations In Tear Mucinsmentioning

confidence: 99%

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BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

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Contact lens materials have undergone significant changes over the past 20 years, particularly with respect to the introduction of silicone hydrogel materials. Whilst this development addressed hypoxic issues, other important areas relating to contact lens success, notably comfort, require further research.Contact lens wettability remains a crucially important part of biocompatibility. Contact lenses can be made more wettable by incorporation of surfactants into blister packs, internal wetting agents, surface treatments or care solutions. However, there remains no clear association between contact lens wettability and comfort, making it challenging to determine the potential for these approaches to be of significant clinical benefit. Most contact lenses are used on a daily wear, reusable basis, which requires them to be disinfected when not worn. The ideal disinfecting solution would also improve comfort during wear. However, balancing these requirements with other factors, including biocompatibility, remains a challenge. Soft lens materials invariably take up and subsequently release certain components of disinfecting solutions onto the ocular surface. This may affect tear film stability and the normal ocular microbiome, and further research is needed in this area to determine whether this has any affect on comfort. Finally, contact lens materials sorb components of the tear film, and these interactions are complex and may change the biochemistry of the tear film, which in turn may affect their comfort.In conclusion, the interaction between lens materials, tear film and disinfection solution plays an important role in the biocompatibility of lenses. However, the exact role and whether this can be altered to improve biocompatibility and comfort during wear remains debatable. This report summarises the best available evidence to examine this complex relationship and the opportunities for practitioners to enhance in-eye comfort of contemporary lenses, along with providing suggestions for areas of study that may provide further information on this topic.

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Section: Discussionmentioning

confidence: 99%

Section: Contact Lenses and Alterations In Tear Mucinsmentioning

confidence: 99%

Section: Contact Lenses and Alterations In Tear Mucinsmentioning

confidence: 99%

See 1 more Smart Citation

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

Self Cite

View full text Add to dashboard Cite

show abstract

“…On the other hand, increased microvascular density in the lid wiper was significantly correlated with decreased contact lens comfort [266]. Recently, a study investigating the use of fluorescein-labelled wheat germ agglutinin as a marker for ocular surface mucins found that symptomatic lens wearers showed reduced wheat germ agglutinin fluorescence in the lid wiper, which may suggest altered density and/or structure of mucins [267].…”

Section: Lid Wiper Epitheliopathymentioning

confidence: 99%

BCLA CLEAR - Effect of contact lens materials and designs on the anatomy and physiology of the eye

Morgan

Murphy

Gifford

et al. 2021

Contact Lens and Anterior Eye

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“…Ocular mucin with hydrophilic properties and rich negative charges is the main component of the tear film, which benefits to stabilize the tear film, wet the cornea, and prevent the invasion of pathogens (Georgiev et al, 2019;Read et al, 2019). Meanwhile, it also prevent the effective dose of the drug from reaching the target tissue (Hori 2018).…”

Section: Surface Hydrophobicity Evaluationmentioning

confidence: 99%

Incorporation of ion exchange functionalized-montmorillonite into solid lipid nanoparticles with low irritation enhances drug bioavailability for glaucoma treatment

et al. 2020

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Montmorillonite-loaded solid lipid nanoparticles with good biocompatibility, using Betaxolol hydrochloride as model drug, were prepared by the melt-emulsion sonication and low temperature-solidification methods and drug bioavailability was significantly improved in this paper for the first time to application to the eye. The appropriate physical characteristics were showed, such as the mean particle size, Zeta potential, osmotic pressure, pH values, entrapping efficiency (EE%) and drug content (DC%), all showed well suited for possible ocular application. In vitro release experiment indicated that this novel system could continuously release 57.83% drugs within 12 h owing to the dual drug controlled-release effect that was achieved by ion-exchange feature of montmorillonite and structure of solid lipid nanoparticles. Low irritability and good compatibility of nanoparticles were proved by both CAM-TBS test and cytotoxicity experiment. We first discovered from the results of Rose Bengal experiment that the hydrophilicity of the drug-loaded nanoparticles surface was increased during the loading and releasing of the hydrophilic drug, which could contribute to prolong the ocular surface retention time of drug in the biological interface membrane of tear-film/cornea. The results of in vivo pharmacokinetic and pharmacodynamics studies further confirmed that increased hydrophilicity of nanoparticles surface help to improve the bioavailability of the drug and reduce intraocular pressure during administration. The results suggested this novel drug delivery system could be potentially used as an in situ drug controlled-release system for ophthalmic delivery to enhance the bioavailability and efficacy.

show abstract

The impact of contact lens wear on ocular surface mucins using a novel clinical fluorescence imaging system

Cited by 12 publications

References 52 publications

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

BCLA CLEAR - Effect of contact lens materials and designs on the anatomy and physiology of the eye

Incorporation of ion exchange functionalized-montmorillonite into solid lipid nanoparticles with low irritation enhances drug bioavailability for glaucoma treatment

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