The impact of continuous haemofiltration with high-volume fluid exchange during cardiopulmonary bypass surgery on the recovery of patients with impaired renal function: a pilot randomised trial

Abstract

Health Technology Assessment is indexed in MEDLINE, CINAHL, EMBASE, The Cochrane Library and the ISI Science Citation Index and is assessed for inclusion in the Database of Abstracts of Reviews of Effects.This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions.For more information about the HTA programme please visit the website: www.hta.ac.uk/ This reportThe research reported in this issue of the journal was funded by the HTA programme as project number 08/53/33. The contractual start date was in April 2010. The draft report began editorial review in May 2012 and was accepted for publication in January 2013. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the draft document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are thos...

The Effect of the Hemofiltration-Body Surface Area on the Mortality and Morbidity during Cardiopulmonary Bypass

“…In a randomized pilot study published in 2013, the effects of hemofiltration during CBP on hospital cost were investigated. In this study, the time to extubation and the length of intensive care unit stay were taken as criteria and the value of mortality was considered important [22]. In hemofiltration group, intensive care unit stay was found to be less than control groups.…”

Acute Kidney Injury in Cardiac Surgery and Cardiac Intensive Care

“…A pilot study of the impact of hemofiltration during cardiopulmonary bypass on cardiac surgery patients with impaired renal function has recently been completed. 191…”

Outcome of Ultrafiltration in On-pump vs Off-pump Coronary Artery Bypass Grafting in Patients with Renal Impairment

“…Mechanisms that could contribute to renal dysfunction from CPB in CKD patients include signi cant hemodilution, and post-bypass systemic in ammatory response syndrome (SIRS) inducing kidney injury. Therefore, several strategies have been developed to protect the kidney while running the CPB circuit (2).…”

“…Ultra ltration is a technique that uses a semipermeable membrane. These membranes are connected in a CPB circuit to remove excessive uid, remove in ammatory mediators, and create a hemoconcentration (2). It works similarly to hemodialysis, except it cannot ltrate waste products from serum.…”

“…MUF also uses a lter similar to CUF but the circuit is connected to the CPB in series and runs MUF after CPB is nished. The MUF technique can ltrate a larger amount of excess water and more concentrated blood than CUF (1,2). Moreover, some studies found that MUF can reduce in ammatory mediators, therefore MUF could reduce SIRS (3).…”