“…In the early years from 2011 to 2013, UC research began to focus on (Actis et al, 2019) cystic fibrosis, asthma, breast cancer, and osteoporosis (Kaplan, 2015); primary sclerosing cholangitis, rheumatoid arthritis, systemic lupus erythematosus, and ankylosing spondylitis (Wilks, 1859); celiac disease, pouchitis, and familial adenomatous polyposis (Viola et al, 2021); abnormal motility, colonic permeability, and enteric nervous system (Nguyen et al, 2018); adipose tissue (Lucaciu et al, 2021); epidemiology, gene polymorphism, susceptibility loci, drug delivery, and activity index (Connelly et al, 2016); dextran sulfate sodium (DSS) and acetic acid (Schöffel et al, 2021); guinea pig (Schöffel et al, 2016); N-acetylcysteine, fish oil, and vitamin D (Chen, 2006); 5-aminosalicylic acid (5-ASA), sulfasalazine, olsalazine, and chitosan (Van Eck and Waltman, 2010); cyclosporin, 6-mercaptopurine, methotrexate, and azathioprine (Aksnes, 2003); certolizumab pegol, infliximab, etanercept, adalimumab, and tacrolimus (Bardeesi et al, 2021); Adacolumn, leukocytapheresis, and apheresis (Freeman, 1977); probiotics, antibiotic therapy, curcumin, traditional Chinese medicine, and electroacupuncture (Cobo et al, 2011); colectomy, ileostomy, and ileal pouch-anal anastomosis; (Kessler, 1963); liver transplantation (Marshakova, 1973); confocal laser endomicroscopy and PillCam colon capsule endoscopy (Small, 1973); C-reactive protein, lactoferrin, and fecal calprotectin (Sandborn et al, 2012a); E-cadherin (Sandborn et al, 2017); Epstein-Barr virus and cytomegalovirus infection (Feagan et al, 2013); Helicobacter pylori, gut microbiota, Escherichia coli, and Clostridium difficile infection (Kleinberg, 2003); short-chain fatty acids, butyrate, and bile acid (Cohen et al, 2010); innate immunity (Ng et al, 2017); regulatory T (T reg ) cell, T helper 17 (Th17) cell, natural killer T cell, and mast cell (Burisch et al, 2020); enterochromaffin cell (Livas et al, 2021); antineutrophil cytoplasmic antibody and anti-Saccharomyces cerevisiae antibody (Glänzel and Thijs, 2004); angiogenesis...…”